1/2. Aggressive osteoblastoma of the mandible closely simulating calcifying epithelial odontogenic tumor. Report of two cases with unusual histopathologic findings.Aggressive osteoblastoma is a rare bone-forming neoplasm composed of prominent epithelioid cells that demonstrate locally invasive growth with a high rate of recurrence but no metastatic potential. Clinical, radiographic and pathologic features of mandibular aggressive osteoblastoma in a 21-year-old African-American male and a 12-year-old Caucasian female are presented. Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy. The patients showed no evidence of local recurrence or distant spread either clinically or radiographically after two years of follow-up. These tumors were composed of solid sheets of pleomorphic epithelioid cells, eosinophilic amorphous osteoid with foci of calcification, which closely simulated amyloid. Differentiation of this tumor from histologically similar calcifying epithelial odontogenic tumor and low-grade osteosarcoma proved difficult. Immunohistochemical study with osteocalcin confirmed the osteoblastic nature of these epithelioid cells.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/2. Unusual osteolytic midline lesion of the skull: benign osteoblastoma of the parietal bone.The authors report the case of a 5-year-old girl who presented with a parietal midline sub-scalp lesion. skull radiographs demonstrated a lytic lesion surrounded by a sclerotic rim that resembled a dermoid cyst of the cranium. Histopathological analysis proved that the lesion was a benign osteoblastoma. As in other calvarial masses of uncertain nature, after diagnostic workup, we recommend surgical excision both for diagnosis and for treatment.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |