11/35. Chronic abdominal pain caused by heterotopic ossification with functioning bone marrow: a case report and review of the literature.Heterotopic ossification is rarely seen after midline abdominal surgery. The etiology of heterotopic ossification is unknown. Although it is well recognized that heterotopic ossification may contain osteogenic cells and/or hematopoietic cells, to our knowledge, no case has ever been reported to have histologic evidence of hematopoiesis. We report the occurrence of heterotopic bone with bone marrow showing normal trilineage hematopoiesis in the incision scar of a woman who underwent gastric reduction surgery for the treatment of obesity. The literature regarding heterotopic ossification and extramedullary hematopoiesis is reviewed in this report, and discussion focuses on the mechanism of this pathophysiologic process.- - - - - - - - - - ranking = 1keywords = abdominal pain (Clic here for more details about this article) |
12/35. Aspiration cytology of heterotopic ossification. A case report.Heterotopic ossification (myositis ossificans) is usually a posttraumatic reactive process involving new bone formation. This nonneoplastic process can be clinically and radiologically confused with osteosarcoma. A case of heterotopic ossification is reported in which cytologic material was obtained from a partially calcified thigh mass from a 17-year-old, athletic male. Aspiration cytology revealed numerous osteoclastic giant cells containing multiple plump nuclei. These cells were admixed in a benign-appearing stromal background composed of mature fibroblasts and were typified by elongated spindle cells. A small incisional biopsy showed new bone formation, osteoclasts, osteoblasts and fibroblasts consistent with maturing heterotopic ossification. Heterotopic ossification may be distinguished cytologically from osteosarcoma by the presence of numerous uniform benign stromal cells composed of mature fibroblasts and osteoclastic giant cells. The differential diagnosis may be more difficult in the early stages of this reactive and proliferative process. Adequate sampling of suspected heterotopic ossification by aspiration cytology may avoid surgery in a selected group of patients.- - - - - - - - - - ranking = 0.24393096532732keywords = back (Clic here for more details about this article) |
13/35. Ossifying gastric carcinoid tumor containing bone morphogenetic protein, osteopontin and osteonectin.We report a case of gastric carcinoid tumor with ossification. A 47-yr-old man complaining of abdominal discomfort underwent gastrointestinal endoscopic examination, which revealed a submucosal tumor in his stomach. The tumor was extirpated by endoscopic enucleation. Histologically, the tumor was widely occupied by mature bone tissues, where scattered carcinoid tumor cell nests surrounded bone tissues or located in stromal areas. Immunohistochemically, the tumor cells were strongly positive for cytokeratin, chromogranin a, synaptophysin, neurofilaments and neuron-specific enolase, underscoring the diagnosis of carcinoid tumor. They also stained positive with markers of bone formation and differentiation, such as bone morphogenetic protein, osteopontin and osteonectin. There are only four cases in the world literature, including a current case of ossifying gastric carcinoid tumor, in which the excessive production of peptides promoting ossification was considered to be implicated in the unusual appearance of the bone.- - - - - - - - - - ranking = 3.4726536695733keywords = discomfort (Clic here for more details about this article) |
14/35. Heterotopic bone formation in abdominal incisions.Heterotopic bone formation in vertical abdominal wounds is a not infrequent and sometimes disabling complication of abdominal surgery, occurring predominantly in males. Excision of the bone is indicated only for marked discomfort or pain, usually produced by an active lifestyle. Under these circumstances, recurrence of bone following excision, would be highly undesirable and the prophylactic use of etidronate disodium may well be indicated to prevent new bone formation, as demonstrated by one of our cases (Case 8).- - - - - - - - - - ranking = 3.4726536695733keywords = discomfort (Clic here for more details about this article) |
15/35. Ossifying cardiac myxoma with neovascularity.We report a 64-year-old man with ossifying cardiac myxoma which radiographically demonstrated visible calcification. A lateral chest radiograph showed abnormal calcification in the cardiac shadow. Two-dimensional and transesophageal echocardiography revealed a heterogeneous mass with a hyperechoic lesion in the left artium. A coronary angiogram showed a neovascular formation extending from the coronary arteries to the tumor. The resected tumor was composed of round or spindle shaped cells with myxoid stroma, accompanied by extensive calcification and ossification containing fatty and hematopoietic marrow tissue. Although a left atrial calcified myxoma is less common than a right sided myxoma, and such radiographically detectable calcified tumors are rare, the presence of radiographic visualized calcification in the cardiac shadow should be ruled out for left as well as right atrial myxomas.- - - - - - - - - - ranking = 0.071995067256243keywords = chest (Clic here for more details about this article) |
16/35. Desmoid tumor with ossification in chest wall: possible involvement of BAMBI promoter hypermethylation in metaplastic bone formation.A rare case of desmoid-type fibromatosis with focal metaplastic bone in the chest wall suggested that enhanced responsiveness to BMP signaling by decreasing BAMBI expression through promoter hypermethylation plays a crucial role in the formation of metaplastic bone. INTRODUCTION: Desmoid-type fibromatosis, originating from mesenchymal cells with myofibroblastic features, is a locally aggressive and frequently recurring infiltrative lesion. One such sporadic case with metaplastic ossification in the chest wall is presented. MATERIALS AND methods: A 43-year-old man was referred to the hospital with a gradually enlarging hard mass in the left anterolateral chest wall. A thoracotomy was carried out, and histopathological specimens were used for immunohistochemical, genetic, and methylation studies. RESULTS: Accumulation of altered beta-catenin associated with a somatic heterozygous activating mutation in codon 41 was detected in the typical desmoid-type fibromatosis and at the ossifying focus. Among factors related to bone formation and the classical wnt-beta-catenin signaling pathway, BMP and activin membrane-bound inhibitor (BAMBI) expression was specifically downregulated at the ossifying focus. Hypermethylation of the BAMBI promoter was observed in microdissected tissue from the ossifying focus but not in that from the typical desmoid-type fibromatosis. CONCLUSIONS: Because both BMP and classical Wnt/beta-catenin/LEF1 signaling cooperatively and mutually induce differentiation of mesenchymal cells into osteoblastic cells and promote bone formation, the epigenetic event leading to the enhanced responsiveness to BMP signaling may play a crucial role in the formation of metaplastic bone.- - - - - - - - - - ranking = 0.5039654707937keywords = chest (Clic here for more details about this article) |
17/35. Ossified soft tissue leiomyoma in a patient with sickle cell anemia.Osseous metaplasia in leiomyomas is extremely rare. Here, we report the case of an ossified subcutaneous leiomyoma in a 34-year-old African American man with sickle cell thalassemia who presented with a painful nodule of the scapular region, which appeared as a heavily mineralized soft tissue mass on chest radiographs. Histopathologic and immunohistochemical examination of the resected nodule revealed a benign soft tissue leiomyoma composed of intersecting fascicles of spindle cells that strongly expressed smooth muscle actin and caldesmon. Extensive intratumoral calcification and ossification were noticed. Only eight cases of ossified leiomyoma have been reported, of which two arose in the deep soft tissue.- - - - - - - - - - ranking = 0.071995067256243keywords = chest (Clic here for more details about this article) |
18/35. Ossified mucin-secreting choroid plexus adenoma: case report.This is the first report of a fully documented case of an ossified mucin-producing benign choroid plexus tumor. This was a chance finding in a man who complained only of posttraumatic low back discomfort. The ossification of the tumor appears to have been therapeutic. Mucin production may be a defense mechanism.- - - - - - - - - - ranking = 3.7165846349006keywords = discomfort, back (Clic here for more details about this article) |
19/35. The diagnostic challenge of styloid elongation (Eagle's syndrome).Eagle's syndrome is a relatively common disorder that is frequently misdiagnosed. It occurs more frequently in women. Presenting symptoms generally include posterior oropharyngeal pain, intermittent glossitis, and phantom foreign body discomfort of the pharynx. Surgical removal of elongated styloid processes generally provides relief of symptoms.- - - - - - - - - - ranking = 3.4726536695733keywords = discomfort (Clic here for more details about this article) |
20/35. Metastatic ossified gastric carcinoid with hypergastrinemia associated with gastric and thyroid autoantibodies.A 42-year-old white woman was seen by her physician because of somatic complaints of the neck and right arm discomfort, difficulty in swallowing, and "heartburn." Findings of the workup led to the diagnosis of metastatic ossified gastric carcinoid. review of the literature suggests that this is the third report of ossified gastric carcinoid. However, this is the only case in which such a tumor was associated with hypergastrinemia, gastric (antiparietal cell), and thyroid (antimicrosomal) autoantibodies.- - - - - - - - - - ranking = 3.4726536695733keywords = discomfort (Clic here for more details about this article) |
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