1/6. A case of lichen planus of the penis mimicking leukoplakia lesions: a review of differential diagnosis.We describe a case of a 50-year-old man with lesions localized in the region of urethral meatus and on the epithelium of the foreskin. The lesions were observed as the white spots with flat or somewhat depressed surface, locally similar to leukoplakia, lichen sclerosus atrophicus or cicatrix, without any subjective symptoms. cystoscopy, micturition urography and biopsy were performed by urologist. The diagnosis of lichen planus Wilsoni was made based on the biopsy examination. We obtained great improvement of lesions through the applied local therapy- - - - - - - - - - ranking = 1keywords = leukoplakia (Clic here for more details about this article) |
2/6. Exacerbation of oral erosive lichen planus by combination of interferon and ribavirin therapy for chronic hepatitis c.hepatitis c virus (HCV) induces extrahepatic manifestations such as oral lichen planus (OLP) as well as chronic liver diseases. The treatment of HCV-related chronic liver disease has evolved from the use of a single agent, mainly interferon (IFN), to the combination of IFN and ribavirin. We present a case of erosive OLP, cutaneous lichen planus (CLP), and leukoplakia of the vocal cord in a man with chronic hepatitis c infection treated with IFN and ribavirin. A 65-year-old man suffered from OLP before undergoing combination of IFN and ribavirin therapy for chronic hepatitis c. He was initially treated with IFNbeta (6 million units (MU) /day for 2 weeks), then a combination of IFNalpha-2b (6 MU/day for 2 weeks and 3 times a week for 14 weeks) and ribavirin (400-600 mg/day). The OLP lesion was not aggravated by application of steroids during the 7 weeks after the treatment, but after 18 weeks, the combination of IFN and ribavirin was stopped because of aggravation of the OLP. Elevated aminotransferase levels returned to normal during the therapy. But 7 weeks after discontinuation, aminotransferase levels rose to 10 times the normal range. Five months after discontinuation, the papules of CLP appeared. Eight months after discontinuation, the OLP erosion had gradually reduced, but some erosion remained. Aminotransferase levels were decreased, but serum HCV rna had not disappeared. Caution should be exercised when IFN or ribavirin therapy is given to chronic hepatitis c patients with prior erosive OLP.- - - - - - - - - - ranking = 0.2keywords = leukoplakia (Clic here for more details about this article) |
3/6. Interferon activity and its characterization in the sera of patients with premalignant lesions arising in oral mucosa.The interferon (IFN) assay of the sera from the 26 patients with premalignant lesions such as lichen planus and leukoplakia arising in oral mucosa was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human amniotic membrane. When the serum IFN activity was characterized by acid treatment, significant increase of acid-stable IFN in the patients was found as compared with those in the normal controls. The titers of gamma-like IFN defined by anti-HuIFN-alpha and anti-HuIFN-beta in the sera of patients of 50-79 years age group (n = 17, P less than 0.002) showed a highly significant increase as compared with the relevant normal controls (n = 20). All of the 26 patients were treated with topical administration of HuIFN-beta. When the correlation between prognosis of the disease and titers of serum IFN was investigated by measuring gamma-like IFN and acid-stable IFN in the sera of patients, all of 13 patients with good prognosis after the HuIFN-beta therapy showed significantly decreased levels of gamma-like IFN (P less than 0.01), whereas the serum level of acid-stable IFN after HuIFN-beta therapy showed a significant increase compared to that before the therapy (P less than 0.05). These findings indicate that the endogenous IFN system may be associated with the pathophysiology in patients with the oral mucosal lesions.- - - - - - - - - - ranking = 0.2keywords = leukoplakia (Clic here for more details about this article) |
4/6. Therapeutic effect of human fibroblast interferon on premalignant lesions arising in oral mucosa. A pilot study.Human fibroblast interferon (HuIFN-beta) was topically administered to 20 premalignant lesions histopathologically showing epithelial dysplasia such as leukoplakia and lichen planus which arose in the oral mucosa. HuIFN-beta was prepared in the water-soluble gel form containing 2% carboxymethylcellulose, 45% glycelin, 0.1 M citrate buffer (pH 4.5) and 0.2% SDS as stabilizing agents. This preparation was found to be effective for herpetic gingivostomatitis and zostal lesions arising along the intercostal nerve. Thus, the HuIFN-beta preparation (10(4) to 5 X 10(3) IU) was applied to the oral mucosal lesion for 1 h twice a week. The lesion with topical administration of HuIFN-beta was covered tightly with the mucosal bandage which was coated with carboxymethylcellulose, glycelin and CaCl2 on vinyl acetate matrix. The 14 oral lesions with erosion or ulcer formation accompanied by severe pain by touch, had complete remission after approximately 10 successive applications of this preparation. Although subjective symptoms such as irritation pain in the other 6 patients with severe hyperkeratotic lesion subsided, white coatings and streaks could not be completely removed by this therapy. No other side-effects excluding slight pain and reddish swelling which occurred intermittently during HuIFN-beta administration were observed.- - - - - - - - - - ranking = 0.2keywords = leukoplakia (Clic here for more details about this article) |
5/6. dyskeratosis congenita in two male cousins.dyskeratosis congenita is reported in two male Singaporean Chinese cousins. The family pedigree is presented. lichen planus or lichenoid lesions, instead of leukoplakia, was the manifestation in the oral cavity. The mode of inheritance and the differential diagnosis of Fanconi's anaemia are discussed. Dental findings are emphasised as such information is lacking in previously reported cases. One of the subjects expired of aplastic anaemia, which together with oral malignancy, is one fatal complication of this disease.- - - - - - - - - - ranking = 0.2keywords = leukoplakia (Clic here for more details about this article) |
6/6. Transformation of oral lichen planus to squamous cell carcinoma: a literature review and report of case.We have presented a case of malignant transformation of oral lichen planus along with a review of the literature and a brief description of the disease. We have attempted to indicate that within defined terms, oral lichen planus should be considered a pre-malignant lesion in which incidence of transformation approaches that of clinical oral leukoplakia, yet is clearly distinctive from that disease with regard to age and sex distribution. The erosive form of oral lichen planus most often precedes carcinomatous change. A protocol is described for documentation and periodic follow-up procedures for such patients to possibly intercept a developing malignancy.- - - - - - - - - - ranking = 0.2keywords = leukoplakia (Clic here for more details about this article) |