| Two cases of leukoplakia of the anal canal are presented, with illustrations of the typical gross and microscopic appearance. The lesions were asymptomatic, and were discovered by routine rectal examination. Histological findings included hyperkeratosis and acanthosis extending cephalad from the anal verge to the dentate line. Followup after 3 and 15 years revealed no evidence of dysplastic changes, and a review of the literature did not uncover any reported cases with dysplasia or with documented evolution to malignancy. There is little evidence that leukoplakia of the anal canal is premalignant but patients should be followed carefully, since the natural history of this rare lesion is unknown. ( info) |
2/51. Treatment of conjunctival intraepithelial neoplasia with topical drops of mitomycin C. PURPOSE: To evaluate the efficacy and risks of complications of topical mitomycin C (MMC) for small-size conjunctival intraepithelial neoplasia (CIN). methods: Eight patients with clinically diagnosed CIN <8 mm were included in the study. patients received topical drops of MMC, 0.02-0.04%, 4 times daily for 14 days. retreatment was done when lesions were not eliminated or recurred after the first treatment. RESULTS: Three patients remained disease free after one course of MMC application. retreatment was done in four patients because of lesions that decreased in size but were not eliminated, and for regrowth in one case. After retreatment, the lesions were eradicated in four patients, whereas in one patient, the treatment failed, and the lesion was surgically excised. The complications of MMC use included mild conjunctival hyperemia in two patients and mild allergy in one patient, which resolved after discontinuation of the treatment. CONCLUSION: Application of topical MMC is an effective treatment for most but not all cases of small-size CIN. ( info) |
| We herein describe 44 new cases of leukoplakia of the renal pelvis, bladder and urethra. leukoplakia is uncommon. It occurs twice as often in the bladder as in the pelvis and ureter and it is associated with and perhaps caused by chronic infection. carcinoma is present in 10 to 20 per cent of the cases at diagnosis. We believe that leukoplakia is not simple squamous metaplasia but a step further down the line--a process that evolved through squamous metaplasia and perhaps could result in cancer. We think leukoplakia is potentially pre-malignant and it should be treated as a low grade and low stage tumor since no satisfactory treatment exists. ( info) |
4/51. Management of extensive leukoplakia of bladder. A case of extensive leukoplakia of the bladder is presented. The occurrence is unusual and the management controversial. cystectomy should be considered in men with extensive vesical leukoplakia. ( info) |
5/51. Ocular surface squamous neoplasia: report of an unusual case and review of the literature. OBJECTIVE: To describe a case of leukoplakia and underlying intraepithelial squamous cell neoplasia of the palpebral conjunctiva presenting in a patient wearing an ocular prosthesis. methods: The clinical presentation, histopathological findings and surgical outcome are described in a 62-year-old man in whom leukoplakic lesions of the palpebral conjunctiva in a socket fitted with an ocular prosthesis were noted in addition to squamous cell carcinoma of the lower lid skin. RESULTS: Histopathological examination revealed islands of squamous cell carcinoma in the skin lesion and squamous cell carcinoma-in-situ in the leukoplakic conjunctival specimen. Successful tumour excision and lid reconstruction were performed. CONCLUSION: This report highlights the successful treatment of long-standing conjunctival squamous cell carcinoma-in-situ associated with an ocular prosthesis and a general tendency to pre-neoplastic lesions of the skin. Regular examination of the sockets of patients wearing long-standing ocular prostheses is recommended. ( info) |
6/51. Prostatic urethral leukoplakia with prostatic abscess. We present a case of prostatic abscess and coexistent leukoplakia of the urethra in a 51-year-old man. He had been suffering from diabetes mellitus for 10 years and following cessation of high fewer, transurethral electrovaporesection was performed. ( info) |
7/51. Extensive bilateral renal pelvis, ureter and bladder leukoplakia. We are presenting a case of leukoplakia spread to the bilateral renal pelvis, ureter and bladder in a 52-year-old woman. We believe this case is important because it involves leukoplakia that is more extensive than in any cases previously cited in the literature. No other possible etiologic cause except a heavy smoking habit was defined. Conservative follow-up was preferred to aggressive surgery. ( info) |
| An 11-year-old boy had dyskeratosis congenita, elevated fetal hemoglobin level, X-linked ocular albinism, and juvenile-onset diabetes mellitus. A review of the international literature revealed that elevated fetal hemoglobin has been noted in 15 reported cases of dyskeratosis congenita. It is a previously unrecognized, commonly associated finding in dyskeratosis congenita that may provide insight into the location and function of the gene for dyskeratosis congenita. ( info) |
| dyskeratosis congenita is a multisystem disorder with an increased incidence of neoplasia and opportunistic infections. A case is reported as a cause of complete nasopharyngeal atresia. ( info) |
| A 13-yr-old girl with dyskeratosis congenita is presented. Besides oral leukoplakia and nail dystrophies, there was evidence of pancytopenia, growth retardation, alopecia, mental retardation and microcephaly. The oral findings included caries, gingival recession, short-blunted roots, gingival bleeding, tooth mobility and severe alveolar bone loss resembling juvenile periodontitis. ( info) |