1/31. erythema nodosum leprosum in nigeria.The occurrence of erythema nodosum leprosum among leprosy patients treated with diamino diphenyl sulfone in an endemic area is not rare, unlike in the leprosy patients treated at Lagos University teaching Hospital. Two Nigerian patients with this disease are described, in whom this rarity was seen. Recurrent monthly fever with painful skin swellings in lepromatous patients from an edemic area is highly suggestive of erythema nodosum leprosum. The occurrence of this reaction in lepromatous leprosy gives a relatively poor prognosis.- - - - - - - - - - ranking = 1keywords = erythema nodosum, nodosum, erythema (Clic here for more details about this article) |
2/31. Ultrastructure of keloid: an unusual incident involving lepromatous leprosy.A patient with lepromatous leprosy developed keloids on the dorsum of both arms in response to ulcerations due to acute erythema nodosum leprosum reactions. Electron microscopic examination of the keloidal dermis showed a morphology indicative of increased production of normal collagen fibrils. The greatest cellular changes from normal were in fibroblasts which were enlarged due to increased amounts of rough endoplasmic reticulum and extensive Golgi complexes. Nuclear folds were also evident in these fibroblasts. Some cells, considered to be fibroblasts, were filled with cytoplasmic filaments and contained bizarre shaped nuclei. mast cells, blood vessels and nerve processes were also present.- - - - - - - - - - ranking = 0.3750972081921keywords = erythema nodosum, nodosum, erythema (Clic here for more details about this article) |
3/31. leprosy: otolaryngologist's perspective.A patient with hemi-facial erythematous swelling as a result of borderline leprosy and reversal reaction is reported. This uncommon presentation of the disease poses initial diagnostic difficulties to the otolaryngologist. The otolaryngologist must be familiar with otolaryngologic manifestations of leprosy, since early diagnosis and treatment reduces the risk of transmission of the disease and may avoid permanent nerve damage.- - - - - - - - - - ranking = 0.0025644514126365keywords = erythema (Clic here for more details about this article) |
4/31. Complement determinations in the synovial fluid and serum of a patient with erythema nodosum leprosum.Simultaneous serum and synovial fluid CH50, C1, C4, C2, C1 esterase inhibitor and C3 protein were determined in a patient with acute erythema nodosum leprosum. The pattern of synovial fluid complement activity coupled with the demonstration of multiple lepra bacilli free and within histiocytes is more consistent with an infectious than an immune complex induced synovitis.- - - - - - - - - - ranking = 0.6249027918079keywords = erythema nodosum, nodosum, erythema (Clic here for more details about this article) |
5/31. Lepromatous leprosy presenting with polyarthritis, myositis, and immune-complex glomerulonephritis.A Pakistani man aged 19 years was admitted to a rheumatological unit in the United Kingdom with acute widespread polyarthritis accompanied by night sweats and fever. Preliminary examination suggested Reiter's disease, but further investigation showed acute glomerulonephritis with uraemia. The possibility of periarteritis nodosa, and the prominence of muscle tenderness in the legs, led to biopsies of striated muscle and skin, in both of which were changes typical of lepromatous leprosy, with many mycobacterium leprae on Ziehl-Neelsen staining. serum showed IgG-IgM cryoglobulinaemia without antiglobulin activity, and in the recovery phase renal biopsy showed a resolving proliferative glomerulonephritis with linear IgG and IgM immunofluorescence and granular deposits of C3. Clinical signs subsided rapidly under steroid treatment and subsequent progress on anti-leprosy drugs was uneventful. The term erythema nodosum leprosum is inadequate and misleading as a title for a common and important immune-complex reaction of lepromatous leprosy, in which numerous body systems may be involved.- - - - - - - - - - ranking = 0.3750972081921keywords = erythema nodosum, nodosum, erythema (Clic here for more details about this article) |
6/31. Reversal reaction to Hansen's disease.A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented. His clinical features included erythematous, edematous plaques and peripheral neuropathy. Reversal reactions are caused immunologically by enhanced cell-mediated (Th-1) immunity to mycobacterium leprae, resulting in inflammation of infected tissues, such as skin and nerves. Acute neuritis can lead to permanent nerve damage and necessitate prompt treatment with prednisone and/or clofazamine.- - - - - - - - - - ranking = 0.0025644514126365keywords = erythema (Clic here for more details about this article) |
7/31. Remitting seronegative symmetrical synovitis with pitting edema in leprosy.A 67-year-old man, who had widespread and well-defined erythematous violaceous hyperkeratotic plaques on his skin, was diagnosed with borderline tuberculoid leprosy. The patient began treatment with clofazimine, rifampicin, and dapsone, but 15 days afterwards he complained of acral edema with godet sign. magnetic resonance imaging was done, and the case was interpreted as remitting seronegative symmetrical synovitis with pitting edema. About 8 mg/day of methylprednisolone were started with excellent response.- - - - - - - - - - ranking = 0.0025644514126365keywords = erythema (Clic here for more details about this article) |
8/31. Sparing of leprosy macule in ampicillin hypersensitivity rash.A case of tuberculoid leprosy is reported in a middle aged female, who presented with generalised erythematous maculopapular rash which followed ampicillin therapy. In spite of extensive and severe involvement of the skin all over the body by erythema and rash, the hypopigmented patch of leprosy on the face did not show any erythema or rash and stood out more clearly as an island of pale area in the midst of large area of erythema on the face. The possible mechanism of non development of erythema and rash in the patch is discussed.- - - - - - - - - - ranking = 0.012822257063182keywords = erythema (Clic here for more details about this article) |
9/31. Renal granuloma and mesangial proliferative glomerulonephritis in leprosy.A 17-year-old, Yemeni male patient with borderline lepromatous leprosy and erythema nodosum leprosum (ENL) developed a nephritic range proteinuria. A renal biopsy revealed mesangial proliferative glomerulonephritis and epithelioid granulomas in the interstitium. The presence of granular immunofluorescence for C3 and electron-dense deposits in the glomeruli indicated an immune complex glomerulonephritis. Clinical signs of ENL subsided rapidly under steroid treatment. The unusual combination of proliferative glomerulonephritis and epithelioid granulomas in leprosy is presented and discussed.- - - - - - - - - - ranking = 0.3750972081921keywords = erythema nodosum, nodosum, erythema (Clic here for more details about this article) |
10/31. Treatment of chronic erythema nodosum leprosum with cyclosporine A produces clinical and immunohistologic remission.We have treated three leprosy patients suffering from chronic, steroid-dependent erythema nodosum leprosum (ENL) with cyclosporine A (CsA). Excellent results were obtained in two patients. Extra-cutaneous manifestations of the reactional state were completely suppressed, and the development of new skin lesions was sharply curtailed. Immunohistologic abnormalities characteristic of active ENL were corrected. Lymphocyte subpopulations and anti-mycobacterial antibody levels in peripheral blood were unaffected. The third patient showed only a partial response to CsA, but satisfactory blood levels were never obtained in this individual because of dose-related gastrointestinal toxicity. The effectiveness of CsA in the treatment of ENL is consistent with the hypothesis that aberrant activation of a subset of T-helper cells is involved in the pathogenesis of this reaction. CsA may have a role in the treatment of chronic ENL that has failed to respond to conventional therapeutic modalities.- - - - - - - - - - ranking = 1.8754860409605keywords = erythema nodosum, nodosum, erythema (Clic here for more details about this article) |
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