1/15. Fibrous histiocytoma of the larynx.We present a case of fibrous histiocytoma of the larynx in a young female who presented eight years ago and is still alive and well with no evidence of any regional invasion or distant metastasis. This rare lesion has been described in 30 cases previously of which 26 were malignant and four benign. Our case is unusual in a sense that histologically it has not been possible to determine its exact biological behaviour and growth potential. However, clinically it behaved as a low-grade malignant tumour.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/15. Immunoreactivity in granular cell tumours of the larynx.OBJECTIVE: To elucidate histogenesis and behaviour of laryngeal granular cell tumours (GCT) and to determine the role of p53 protein expression in these lesions. methods: The clinical, pathological and immunohistochemical findings of three cases of laryngeal GCTs are described. RESULTS: All tumours were surgically excised and appeared histologically benign. Pseudoepitheliomatous hyperplasia, mitosis and nuclear pleomorphism were not found in any of the three cases. All lesions were negative for keratin 8, desmin and actin. Only one case stained for collagen IV. Positive staining was found for S-100 protein and CD68 in all tumours. Ki-67 and Bcl-2 staining was confined to occasional cells. p53 reactivity was seen in all tumours; positivity ranged from 35 to 42%. The three patients have remained free of disease without complications up to 10 years after treatment. CONCLUSION: Immunohistochemical findings support benign behaviour and a Schwann cell origin for laryngeal GCT. The expression of p53 by granular cells is unclear but appears to be unrelated to behaviour.- - - - - - - - - - ranking = 3keywords = behaviour (Clic here for more details about this article) |
3/15. Pitfalls in the diagnosis and management of laryngeal chondrosarcoma.Chondrosarcomas of the larynx (CS) are uncommon and predominantly affect the cricoid cartilage. In the larynx they have a distinctive biological behaviour and require individual treatment. A retrospective study was made on three cases of CS, all presenting with compromise of the upper respiratory tract. The medical history varied from several weeks to six years. Correct diagnosis required open resection of the lesion in all cases. Due to intra-operative findings, all patients underwent total laryngectomy. CS grow slowly and are therefore frequently diagnosed late in the course of the disease. A subglottic bulging of the mucosa should indicate high-resolution-computed-tomography of the larynx to exclude affection of the laryngeal framework. Correct diagnosis of laryngeal cartilaginous tumours requires a complete examination of the entirely resected tumour. Only extended and de-differentiated CS indicate further radical surgery, the remainder call for conservative surgical management.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
4/15. Recurrent laryngeal papillomatosis: a case of florid papillomatosis following a remission of 30 years.Laryngeal papillomatosis is the commonest benign tumour affecting the larynx. Two forms are found i.e. juvenile onset and adult onset. Typically the juvenile onset form has a greater rate of recurrence and often remits with the onset of puberty (Corbitt et al., 1988). The human papilloma virus (HPV) is the causative agent (Abramson et al., 1987; Corbitt et al., 1988), specifically types HPV6 and 11. Attempts have been made to correlate the clinical behaviour of these two modes with the viral serotype and other aetiological factors such as smoking and hormonal factors (Abramson et al., 1987; Rimmel et al., 1992). Studies, however have shown that there is considerable variation in behaviour (Steinberg et al., 1983; Corbitt et al., 1988; Crissman et al., 1988). It is widely accepted that the disease 'burns' itself out, particularly with respect to the juvenile form. It is interesting and unusual therefore when the disease reappears after many years of remission. The following case report illustrates this point.- - - - - - - - - - ranking = 2keywords = behaviour (Clic here for more details about this article) |
5/15. Malignant fibrous histiocytoma of the larynx.Malignant fibrous histiocytomas of the upper respiratory tract are rare, aggressive mesenchymal neoplasms. We report a case of a glottic malignant fibrous histiocytoma of the larynx on a 54 year old man. Only a few have been reported in the English literature. The clinical behaviour and degree of malignancy of these tumours cannot be predicted. Wide, aggressive excision of the tumour with a margin of normal tissue appears to be the treatment of choice. About two years after total laryngectomy the patient is well and free of disease.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
6/15. Chemodectoma of the larynx. A clinico-pathological study.The present case report is concerned with a clinico-pathological study, including ultrastructural investigation, of a rare and uncommon laryngeal tumour, a chemodectoma, in a 62 year old patient. There have been 23 cases of laryngeal chemodectomas reported in the literature, and only three of them, including our own report, were investigated by electron microscopy. The tumours arise from the superior and inferior larynegeal nonchromaffin paraganglia or possibly from Kultschitzky-cells of the normal bronchial mucosa. Ultrastructurally they have all the characteristics of apudomas whose parent cells (APUD-cells), usually show endocrine function and probably have their origin in the neural crest. The tumours show an aggressive type of behaviour, despite usually benign histological features when compared to chemodectomas at other sites in the head and neck region. Surgery is thus the therapy of choice.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
7/15. Fibrous histiocytoma of the larynx.Fibrous histiocytoma is uncommon in the head and neck region and rare in the larynx. Its behaviour is unpredictable. A case is reported in a 54-year-old male which was treated conservatively initially and which recurred several times over a seven year period. During that time the appearances of the lesion changed from those of a densely collagenous, cytologically benign tumour to those of a richly cellular and potentially malignant neoplasm. laryngectomy was eventually undertaken.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
8/15. Chemodectoma of the larynx.Two cases of chemodectoma of the larynx are presented. Both of them arose from the superior laryngeal glomus in men late in their lives. pain was the landmark of the disease. Both cases showed very aggressive behaviour. In conclusion, these are malignant tumours which should be treated by total laryngectomy. There is no place for radiotherapy in their treatment.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
9/15. Extensive form of progressive multifocal leucoencephalopathy associated with laryngeal carcinoma.A case is reported of the rare association between progressive multifocal leucoencephalopathy and carcinoma. A 66-year-old man underwent a laryngectomy for carcinoma. Four years later he developed a local recurrence. Simultaneously there were behavioural disturbances and a left motor neglect followed by dense hemiplegia and coma. The patient died a further 5 months later. Anergy was demonstrated by skin tests. CT scan showed asymmetrical non-enhancing low-density areas in the hemispheric white matter, brain-stem and cerebellum and neuropathological examination confirmed extensive myelin loss with typical papovavirus inclusions in oligodendrocytes identified by electron microscopy.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
10/15. Spindle cell squamous carcinoma of the larynx. Clinico-pathological study of seven cases.The clinical and pathological findings of seven cases of spindle cell squamous carcinoma of the larynx are reported. The histogenesis, biological behaviour and appropriate therapy of neoplasm are discussed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
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