111/719. Three cases of androgen-dependent disease associated with myotonic dystrophy. Three cases of androgen-dependent disease in females with myotonic dystrophy are described. serum androgens in individuals affected by myotonic dystrophy are known to be lower on average than in normal controls. Despite this these three females developed diseases that are androgen dependent, including acne, hidradenitis suppurativa, androgenetic alopecia and keratosis pilaris. These cases support the hypothesis that the peripheral response to androgens rather than absolute circulating levels of androgens is important in androgen-dependent conditions. ( info) |
112/719. A case of focal acantholytic dyskeratosis occurring on both the lip and the anal canal. Focal acantholytic dyskeratosis has a distinctive histological pattern that is associated with various clinical expressions. It rarely occurs on the lip or the perianal area. We report a patient with focal acantholytic dyskeratosis occurring on both the upper lip and the anal canal. Histopathologically, the lesions showed hyperkeratosis, suprabasilar clefting, epidermal acantholysis and dyskeratosis. This case represents the first report of a focal acantholytic dyskeratosis occurring on both the lip and the anal canal. ( info) |
113/719. Annular atrophic plaques of skin (Christianson's disease). Atrophic plaques with white borders are occasionally seen on sun-exposed areas of the skin. These patients are usually elderly and have solar elastosis. This condition is referred to as annular atrophic plaques of skin and we describe a typical case. ( info) |
114/719. Acquired Blaschko dermatitis-seventh case. The February edition of dermatology Online Journal 2002;7(1):8, contained an article entitled Acquired Blaschko dermatitis.[1] A 64 year old patient with erythematous patches and papules in a reticulate pattern on the left upper extremity and on the left side of the chest, abdomen, back and buttock was described. Three months later, in the Department of dermatology, health Center Krusevac, we examined a 65 year old woman with similar lesions, distributed in a linear pattern on her right lower limb, following the lines of Blaschko. ( info) |
115/719. Report of a new case with four skin diseases. A 70 year old man is presented with four distinct skin diseases that were diagnosed concomitantly. lichen planus, vitiligo, lichen sclerosis, and disseminated actinic porokeratosis were all diagnosed clinically and histologically in this man, who was otherwise healthy. ( info) |
116/719. Linear porokeratosis with giant cornoid lamella. A linear form of porokeratosis, with features that we believe have not been previously described, is presented. The lesions occurred in a dermatome distribution; some of them had a central mass of parakeratotic keratin, shaped like a horn, which we designated a "giant cornoid lamella." ( info) |
117/719. Cutaneous undifferentiated small (Merkel) cell carcinoma, that developed synchronously with multiple actinic keratoses, squamous cell carcinomas and basal cell carcinoma. Merkel Cell carcinoma (MCC) is an uncommon undifferentiated neuroendocrine tumor, arising in skin mainly on sun-exposed areas. We present an unusual case of primary cutaneous undifferentiated small cell carcinoma that co-existed with six other lesions; 2 actinic keratoses, 3 squamous-cell carcinomas and a basal-cell carcinoma. HE stained sections revealed MCC located in the mid-dermis, co-existing with severe actinic keratosis. Immunohistochemically, the tumor cells reacted to cytokeratin 20, epithelial membrane antigen, chromogranin and neuron specific enolase. This is an unusual case of cutaneous MCC co-existing with six other different lesions. The concurrent development of MCC, squamous-cell and basal-cell carcinoma in the same patient indicates the pluripotent epidermal stem cell origin of these tumors. Further research is needed to enlighten the factors inducing this divergent differentiation. ( info) |
118/719. Perforating calcific elastosis. A 69-year-old white multiparous woman presented a reticulated yellowish patch with scattered keratotic papules on her abdomen. Histopathological examination demonstrated pseudoxanthoma elasticum (PXE)-like changes. The diagnosis of perforating calcific elastosis (PCE) was made based on the absence of a personal and familial history of PXE. PCE is a localized acquired dermatosis and is considered to be a distinct clinical entity. ( info) |
119/719. Giant acquired digital fibrokeratoma. We describe a 33-year-old patient with a giant skin tumor on her right big toe. The tumor was characterized by unusual clinical manifestations including huge size and papillomatous surface. Chronic long-standing irritation as a result of aerobic exercise may have been involved in the development of giant fibrokeratoma with papillomatous surface. ( info) |
120/719. Keratosis lichenoides chronica. Possible variant of lichen planus. A chronic, asymptomatic, keratotic, papular eruption, present for 15 years and resistant to all modes of therapy, was observed in a 49-year-old woman. Many of the papules formed a reticulated configuration over the arms and legs. This case resembles several others that have been described in the literature under different names, ie, keratosis lichenoides chronica, porokeratosis striata, and lichen verrucosus et reticularis. It is likely that all of these names refer to the same condition, constituting a definite clinical entity, which, on the basis of histological study, may represent a variant of lichen planus. ( info) |