11/23. Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding.We report a 3-week-old boy with cholestatic hepatitis, most likely due to carbamazepine exposure during pregnancy and breastfeeding. cholestasis resolved after cessation of nursing. liver function test results and histological findings were compatible with a drug-induced hepatitis. Other causes were excluded. While carbamazepine-induced hepatitis is well known in children and adults, it has never been described in association with prenatal exposure and/or breast-feeding.- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
12/23. Immune haemolytic anaemia after exchange transfusion.Two cases of immune haemolytic anaemia in newborn infants who had received exchange transfusion on the first day of life because of hyperbilirubinaemia probably due to a conjugation defect, are reported. The first baby, born in the 30th week of gestation presented erythrocyte-fixed IgM antibodies C, neutropenia, and circulating leucocytotoxic antibodies. The second baby, born at term to a diabetic mother showed erythrocyte-fixed IgG IgM antibodies C and a selective IgA deficit. In both cases the anaemia improved and the coombs test became negative spontaneously in the 4th and 5th months of life, respectively. These haematologic alterations are similar to a graft versus host (GVH) reaction due to the persistence in the neonate blood of the donor's immunocompetent cells.- - - - - - - - - - ranking = 0.12188282813539keywords = gestation (Clic here for more details about this article) |
13/23. Unexplained neonatal jaundice as an early diagnostic sign of septicemia in the newborn.This prospective study was performed to determine the frequency of unexplained unconjugated hyperbilirubinemia associated with bacterial infection during the first week of life. Of 5805 infants delivered between September 1984 and December 1986, 93 jaundiced newborns without evidence of septicemia fulfilled the following criteria to be enrolled in the study: weight greater than 2500 g, gestational age greater than 38 weeks, age less than 7 days, and unexplained unconjugated bilirubin greater than 170 mumol/L (greater than 10 mg/dL) during the first 48 hours of life and/or greater than 255 mumol/L (greater than 15 mg/dL) thereafter. Evaluation for septicemia included blood and urine cultures, and white cell and thrombocyte counts. The study disclosed three (3.2%) infants who developed septicemia before any clinical suspicion had been aroused. It is concluded that bacterial infections should be considered a possible cause of neonatal unconjugated hyperbilirubinemia during the first week of life, regardless of the clinical condition of the infant.- - - - - - - - - - ranking = 0.12188282813539keywords = gestation (Clic here for more details about this article) |
14/23. Influence of maternal antibody anti-Jra on the baby: a case report and pedigree chart.A Jr(a-) female (proposita) who has developed anti-Jra during her second pregnancy and her pedigree chart are reported. The antibody anti-Jra of the proposita and her baby was determined to be IgG and was eluted from their red cells. The baby's bilirubin rose to a peak on day 4 without clinical problem except for prophylactic phototherapy carried out. Two other examples of Jr(a-) blood type were detected in her elder sister and the first baby of the proposita with investigation of her pedigree chart.- - - - - - - - - - ranking = 0.2keywords = pregnancy (Clic here for more details about this article) |
15/23. Diabetes and graves disease complicating pregnancy.We report here six pregnancies in 5 women with juvenile diabetes and graves disease. The diabetes was managed in a standard fashion. The graves disease was managed with propylthiouracil when required. The course of neither the diabetes nor graves disease was different than expected. When established guidelines for therapy are followed the two have no interaction with one another. One infant was mildly hypothyroid. None developed neonatal graves disease. Four of the infants had hyperbilirubinemia.- - - - - - - - - - ranking = 0.8keywords = pregnancy (Clic here for more details about this article) |
16/23. Successful pregnancy in beta-thalassaemia major.Successful pregnancy is described in a patient with beta-thalassaemia major, transfusion-dependent from four months of age and treated with desferrioxamine from 13 years of age. The pregnancy was concealed. No antenatal care was given nor any planned alteration in management of her thalassaemic state.- - - - - - - - - - ranking = 1.2keywords = pregnancy (Clic here for more details about this article) |
17/23. A new therapeutic antibody removal method using antigen-positive red cells. II. Application to a P-incompatible pregnant woman.Therapeutic antibody removal using antigen-positive red cells was applied to a pregnant woman who has high titered IgG anti-P and had lost all of 4 previous fetuses in P-incompatible pregnancy. The treatment was commenced at the 6th week of gestation and was intensively performed 93 times up to the 35th week. The volume of plasma treated was 2.3 1 per procedure on the average and totalled 215 1. The antibody titer was kept at a low level. At the end of the 35th week of gestation a female infant was delivered by cesarean section. The baby did not require an exchange transfusion and encountered no complications.- - - - - - - - - - ranking = 0.44376565627077keywords = pregnancy, gestation (Clic here for more details about this article) |
18/23. D-penicillamine treatment of hyperbilirubinaemia in preterm infants.In 41 hyperbilirubinaemic infants born before the 38th gestational week intravenous D-penicillamine treatment was applied in doses of 300 mg/kg body weight/day. As compared to 41 infants of identical gestational age and treated under identical circumstances, penicillamine ensured favourable results, especially in babies born after the 33rd gestational week. Some undesirable side-effects have to be taken into account, but they are infrequent if the indication is correct.- - - - - - - - - - ranking = 0.36564848440616keywords = gestation (Clic here for more details about this article) |
19/23. Successful exchange transfusion of an infant for AIHA developing late in mother's pregnancy.A 25-year-old woman with apparently inactive Hodgkin's disease developed fulminant autoimmune hemolytic anemia in the 37th week of pregnancy. The baby required four exchange transfusions for hyperbilirubinemia. The same IgG antibody was found in mother and infant.- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
20/23. Fetal exposure to maternal hyperbilirubinemia. Neonatal course and outcome.A case of prolonged fetal exposure to hyperbilirubinemia occurred in a mother with end-stage liver disease during the second and third trimester of pregnancy. At birth, the infant had elevated levels of both conjugated and unconjugated serum bilirubin that required multiple-exchange transfusions during the first three days of life. The infant exhibited abnormal neurologic findings at birth that resolved during the neonatal period. The results of subsequent developmental and neurologic evaluation were normal at 14 months of follow-up. Prolonged fetal exposure to elevated serum bilirubin levels may not necessarily result in developmental or neurologic handicap.- - - - - - - - - - ranking = 0.2keywords = pregnancy (Clic here for more details about this article) |
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