1/3. ABO incompatibility due to immunoglobulin g anti-B antibodies presenting with severe fetal anaemia.ABO incompatibility is a common haematological problem affecting the newborn. The haemolysis is widely accepted to follow a relatively benign course rarely causing the escalating levels of hyperbilirubinaemia and significant anaemia associated with Rh haemolytic disease of the newborn. case reports of fetal hydrops secondary to ABO incompatibility are particularly rare. We describe two cases, first that of a twin pregnancy with both fetuses developing severe anaemia at 20 weeks gestation, and then a second case of a preterm baby demonstrating aggressive haemolysis and anaemia within hours of delivery. Both mothers were of black Africian origin and both were identified to have elevated titres of IgG anti-B antibodies.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
2/3. Immune haemolytic anaemia after exchange transfusion.Two cases of immune haemolytic anaemia in newborn infants who had received exchange transfusion on the first day of life because of hyperbilirubinaemia probably due to a conjugation defect, are reported. The first baby, born in the 30th week of gestation presented erythrocyte-fixed IgM antibodies C, neutropenia, and circulating leucocytotoxic antibodies. The second baby, born at term to a diabetic mother showed erythrocyte-fixed IgG IgM antibodies C and a selective IgA deficit. In both cases the anaemia improved and the coombs test became negative spontaneously in the 4th and 5th months of life, respectively. These haematologic alterations are similar to a graft versus host (GVH) reaction due to the persistence in the neonate blood of the donor's immunocompetent cells.- - - - - - - - - - ranking = 0.85714285714286keywords = anaemia (Clic here for more details about this article) |
3/3. Congenital dyserythropoietic anaemia: report of three cases.Between January 1985 and June 1992, the Paediatric Department of Hospital Universiti Sains malaysia has diagnosed congenital dyserythropoietic anaemia in three children, two of whom were siblings. The age of onset ranged from 1 to 3 years. All of them became transfusion-dependent before the age of 4 months. One of them was successfully treated with bone marrow transplantation.- - - - - - - - - - ranking = 0.71428571428571keywords = anaemia (Clic here for more details about this article) |