Cases reported "Infectious Mononucleosis"

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1/10. Spontaneous cytomegalovirus mononucleosis-like syndrome and aseptic meningitis.

    The spontaneous development of a cytomegalovirus infection in a healthy adult is described. This illness manifested with fever, headache, malaise, an absolute lymphocytosis with atypical lymphocytes, and liver function abnormalities, but without tonsillitis, pharyngitis, lymphadenopathy, or splenomegaly. Aseptic meningitis also was present. The pathogenesis of cytomegalovirus mononucelosis and its relationship to other related syndromes are discussed.
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2/10. Meningoencephalopathy secondary to infectious mononucleosis. Unusual presentation with stupor and chorea.

    We report a case of infectious mononucleosis in which central nervous system involvement was the presenting and sole manifestation of the disorder. The major symptomatology consisted of stupor, chorea, and signs of aseptic meningitis. We also discuss the clinical and laboratory features of the neurological manifestations of infectious mononucleosis and the theories as to its pathogenesis.
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3/10. Mollaret's meningitis associated with acute Epstein-Barr virus mononucleosis.

    A 19-year-old man developed recurrent aseptic meningitis (Mollaret's meningitis) during the course of acute Epstein-Barr virus infectious mononucleosis. serum contained heterophil antibody and Epstein-Barr virus-specific antibodies characteristic of acute infection. Seven brief episodes of aseptic meningitis were documented over the following one-year period, in each case with a polymorphonuclear pleocytosis in the cerebrospinal fluid. Acute infection with Epstein-Barr virus, or subsequent reactivation of virus, may account for some cases of Mollaret's meningitis.
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4/10. cerebellar ataxia in infectious mononucleosis.

    The well-recognised neurological complications of infectious mononucleosis include lymphocytic meningitis, encephalomyelitis with convulsions, cranial and peripheral nerve palsies, guillain-barre syndrome and hemiparesis. Cerebellar involvement is very rare, particularly in females and children. We describe a 14-year-old schoolgirl in whom cerebellar dysfunction proved a dominant feature, and who also gave a previous history of neurological presentation with mumps infection.
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5/10. Cellular elements in the urine in health and in acute infectious diseases, especially with respect to the presence of haematuria. A study with application of millipore procedure and Papanicolaou staining.

    The excretion of cellular per litre of urine amounted in healthy persons to, in round figures, one million epithelial cells (2.5 cells per visual field) in both sexes, one million leukocytes in males, one million erythrocytes in females and 0.5 million in males. The maximal excretion was calculated to be 5-6 million per litre. In acute infections the number of epithelial cells and leukocytes in the urine rose to more than the double. Pathological microscopic haematuria, judged by exceeding of the maximal value for normal excretion during the acute phase (24 or more erythrocytes per visual field), occurred in no case of mycoplasma infection, in about 4% of measles, mononucleosis, serous meningitis and hepatitis cases, in about 8% of mumps and streptococcal infections, and in more than 20% of influenza A2 cases. Statistical significance or probable significant existed between influenza and other diseases. The haematuria was unrelated either to the general degenerative or to the specific inclusion-provocative reaction within the renal and urinary tract epithelium. The cause is sought in an involvement of glomeruli with increased diapedesis. The special position of influenza may be explained by the marked haemorrhagic reactions produced by this infection. In one case persistent haematuria combined with increased content of inclusion-bearing cells occurred after influenza. Immunoglobulin deposition in glomerular mesangium may perhaps be one explanation of this haematuria.
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6/10. fusarium brain abscess. Case report.

    The common soil fungus, fusarium, is rarely pathogenic in man but occasionally causes serious disease, particularly in immunocompromised hosts. A case is reported of fusarium brain abscess and meningitis occurring in a patient with chronic infectious mononucleosis syndrome and immunodeficiency. The patient died despite aspiration of the abscess and treatment with amphotericin b. This case demonstrates the importance of identifying the offending pathological organism through abscess aspiration in immunocompromised patients.
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7/10. The child with a stiff neck.

    The child with a stiff neck can be a challenging diagnostic exercise. Four unusual examples of acute neck stiffness, not associated with meningitis, are presented to illustrate the various pathologic conditions which may produce this symptom. A differential diagnostic schema is suggested on the basis of pathologic and physiologic alterations of cervical and paracervical anatomic structures.
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8/10. Periodic EEG complexes in infectious mononucleosis encephalitis.

    The presence of periodic EEG complexes in patients with an acute viral encephalitis is generally held to suggest that infection is due to herpes simplex. We now report a patient with clinical and laboratory findings of infectious mononucleosis, and neurologic involvement manifested by lymphocyte meningitis, coma, seizures, aphasia, hemiparesis and hemianopsia. Serial EEGs showed periodic, predominantly left-sided slow wave complexes occurring every 4 to 5 seconds, which disappeared with clinical resolution of the illness. In view of our findings and the similar findings reported previously by others in another case of infectious mononucleosis encephalitis, an EEG showing periodic complexes in the clinical setting of acute viral encephalitis should not be considered pathognomonic of herpes encephalitis, and infectious mononucleosis should be included in the differential diagnosis.
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9/10. Acute fatal parainfectious cerebellar swelling in two children. A rare or an overlooked situation?

    We report 2 previously healthy children who developed sudden unexpected respiratory arrest and brain death, during a presumed Epstein-Barr meningitis in one case and a multisystemic infection of unknown etiology in the other. Diffuse swelling of the cerebellum with upward transtentorial and downward tonsillar herniation, shown by brain CT-scan and MRI obtained after the acute event, was the most probable cause of death. review of CT images performed before or at the onset of deterioration already showed discrete signs of early upward herniation of the cerebellar vermis that were initially overlooked. At autopsy in the first case, an acute lymphomonocytic meningoencephalitis with predominant involvement of the cerebellum was observed. Few similar cases were found in the literature, indicating that acute cerebellar swelling is either a very rare or an unrecognized, possibly preventable cause of death in acute inflammatory or non-inflammatory encephalopathies in children.
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keywords = meningitis
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10/10. Severe neurological complications in association with Epstein-Barr virus infection.

    Involvement of the nervous system in infectious mononucleosis is common. About 50% have headache on presentation. neck stiffness without meningitis is a frequent finding. Severe neurological complications are rare though, occurring in fewer than 0.5%. We describe two patients with unusual and severe neurological complications in association with serological evidence of EBV-infection: a 32-year old female developed a bilateral optic neuritis combined with a transverse myelitis and a 72-year old man developed mononeuritis multiplex, autonomic neuropathy and a salt-wasting nephropathy.
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keywords = meningitis
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