1/2. Management of dyslipidemias in the age of statins.Evidence for the effectiveness of lipid-lowering therapy in reducing CHD risk continues to emerge. In primary prevention, clinical trials have demonstrated a benefit for middle-aged, high-risk men with high LDL cholesterol and, more recently, for men and women with "average" LDL and low HDL cholesterol. Although low HDL cholesterol, small dense LDL particles, elevated lipoprotein (a), elevated apolipoprotein B, and the dyslipidemia of the metabolic syndrome pose an increased in CHD risk in some patients, the risk reduction with lipid-lowering therapy has not been fully investigated. The CHD risk of isolated hypertriglyceridemia remains uncertain. Very high triglyceride levels, however, should be treated to prevent pancreatitis. A lipid-lowering diet and other appropriate lifestyle changes constitute safe advice for all patients with dyslipidemia. In initiating pharmacologic therapy, physicians should view potential risk reduction in the context of a patient's overall CHD risk. The selection of particular medications can be individualized, considering effectiveness evidence from clinical trials, lipid-lowering potency, adverse effects, drug interactions, costs, and patient preferences.- - - - - - - - - - ranking = 1keywords = physician (Clic here for more details about this article) |
2/2. Fish oil (omega-3 fatty acids) in treatment of hypertriglyceridemia. A practical approach for the primary care physician.Omega-3 fatty acids, found commercially in fish oil concentrate, may be a useful and safe treatment in lowering elevated triglyceride blood levels. A case is presented of a severely hypertriglyceridemic patient with an idiopathic adverse reaction to gemfibrozil and clofibrate who demonstrated a significant response with fish oil therapy. The benefits and risks of fish oil treatment are discussed.- - - - - - - - - - ranking = 4keywords = physician (Clic here for more details about this article) |