A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins a-I and A-II. Its mechanism of action has not been definitely established.
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