1/18. Sebaceous hyperplasia: a clue to the diagnosis of dermatofibroma.We describe a man with an indurated lesion on his upper back that showed a dermatofibroma with overlying sebaceous hyperplasia. Characteristic dermal features of a dermatofibroma may be sparse or absent in a lesional specimen that has been submitted subsequent to a superficial shave biopsy. hyperplasia of sebaceous glands in a nonfacial lesion is a histologic feature that should prompt the search for a dermatofibroma in the underlying dermis.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/18. Malignant fibrous histiocytoma of the parotid gland.Primary malignant fibrous histiocytoma (MFH) arising in a major salivary gland is rare. We encountered a case of MFH affecting the parotid gland. The patient was a 54-year-old man diagnosed as having pleomorphic type of MFH after extended total parotidectomy. Examination of the resected specimen revealed the tumor had not been completely removed. Accordingly treatment consisted in the resection of MFH and radiotherapy in combination with chemotherapy using carboplatin (CBDCA). This postoperative therapy was effective in controlling the growth of the remaining tumor tissue. As the patient showed no signs of local recurrence and distant metastasis for 5 years, plastic surgery was performed to improve the serious deformation of the face with a free anterolateral thigh flap. Our literature review yielded 17 cases of parotid MFH and the 2-year survival rate was 33%.- - - - - - - - - - ranking = 6keywords = gland (Clic here for more details about this article) |
3/18. Fibrous histiocytoma of the parotid gland.The light microscopic, electron microscopic, and immunocytochemical characteristics of a case of a fibrous histiocytoma arising in the parotid gland is presented. This neoplasm is very rare in this site and must be distinguished from other spindle cell tumors of the parotid gland, particularly those of epithelial and myoepithelial origins. Histologic characteristics similar to those displayed by dermatofibromas and dermatofibrosarcoma protuberans help to differentiate this tumor from other spindle cell tumors. The absence of cytochemical epithelial markers and the electron microscopic demonstration of fibroblasts and histiocytes are useful in establishing the diagnosis. This tumor, which was confined completely to the parotid gland, appears to have arisen from mesenchymal elements within the gland.- - - - - - - - - - ranking = 8keywords = gland (Clic here for more details about this article) |
4/18. pulmonary sclerosing hemangioma associated with familial adenomatous polyposis.A 45-year-old woman presented with asymptomatic solid tumor in the lower right lobe of the lung. Histologically, the tumor comprised a monolayer of surface cells and round stromal cells displaying sclerotic areas. Immunohistochemical studies suggested a diagnosis of sclerosing hemangioma. Interestingly, morular lesions were also observed. Analyses of the gastrointestinal (GI) tract showed mild familial adenomatous polyposis (FAP) and numerous fundal gland polyps, indicating attenuated FAP (AFAP). All components of the sclerosing hemangioma displayed aberrant nuclear and cytoplasmic expression of beta-catenin. However, such findings were much weaker in adenomas of the GI tract and were barely observed in fundal gland polyps. These results strongly suggest an association between sclerosing hemangioma and the AFAP. To the best of our knowledge, this is only the second report of lung tumor associated with FAP and is the first describing an association with sclerosing hemangioma. A new category of FAP-associated lung tumors may be indicated.- - - - - - - - - - ranking = 2keywords = gland (Clic here for more details about this article) |
5/18. Apocrine gland cyst with hemosiderotic dermatofibroma-like stroma: report of two cases.Two cases of an unusual cutaneous lesion characterized by a dermal nodule with apocrine gland cysts surrounded by a hemosiderotic dermatofibroma-like proliferating stroma are reported. The first case was a 52-year-old female who presented with a nodule on the back of several years of evolution and with the clinical diagnosis of lipoma; the second case was a 41-year-old male who presented with a forehead nodule of several years of evolution with a clinical diagnosis of epidermal cyst. Histologically, an ill-delimited non-encapsulated nodule composed of cystic spaces and solid areas was found. The cystic spaces consisted of ductal structures and a bilayered epithelial covering with apocrine differentiation; the surrounding area showed a stroma composed of a mixture of both fibrocytes and macrophages and abundant hemosiderin granules; foci of recent hemorrhages and a more dense fibrous stroma at the periphery with typical storiform areas were also visible. Both cases have shown a benign course without local recurrence in follow up until this report date.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
6/18. Malignant fibrous histiocytoma of the head and neck.review of the literature reveals of 29 cases of fibrous histiocytoma of the deep structures of the head and neck. Three additional cases are reported: a multicentric case involving the submandibular gland with metastases to the lungs; and intraosseous tumor of the mandible locally invasive; and a submental tumor which rapidly recurred after simple excision. A metastatic potential of 22% is established. The historm, nomenclature, histopathology and clinical features are reviewed. The value of electron microscopy and tissue culture in arriving at the current diagnosis are stressed. Wide excision is the treatment of choice.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
7/18. Fibrous histiocytoma of the head and neck: A case report.Fibrous histiocytomas are soft tissue tumors of histiocytic origin. One percent prove to be malignant. Reliable histologic criteria of malignancy are few, if any, and the diagnosis of malignancy often must be made on clinical (metastases) rather than histologic grounds. Thirty-five cases originating in various deep structures of the head and neck, excluding the orbit, have been reported in the literature since 1972. One additional case, a malignant tumor of the submandibular gland, is added herewith. recurrence following initial surgery has been common and stems from inadequate excision of the primary lesion. Microscopic spread of this tumor from its primary site calls for radical rather than conservative surgical excision. At present, radiotherapy and chemotherapy appear to be of little value in the treatment of these tumors.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
8/18. Fibrous histiocytoma of the parotid gland.Fibrous histiocytomas are not uncommonly found in the head and neck region. These tumors, arising from the tissue histiocyte, generally behave in a benign fashion. An unusual case of a fibrous histiocytoma arising in the parotid gland is presented. The histopathology of these lesions as well as parotid neoplasms in children is reviewed. Wide local excision without sacrifice of important structures is the treatment of choice.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
9/18. Juvenile nasopharyngeal angiofibroma.A case of juvenile nasopharyngeal angiofibroma in a 14 year old boy is presented on account of the endocrinological investigation performed before, during, and after treatment with 15 mg/day diethylstilbestrol for more than one month. Previously, the tumor had recurred in spite of extensive surgery. Secondary sexual characteristics were normal and the development of puberty at the age of 12-13 years seemed not to have influenced tumor growth. In contrast to certain previous reports, normal functions were found regarding the pituitary, the gonads, the adrenal cortex, and the thyroid gland in our patient. The tumor continued to grow in spite of the diethylstilbestrol therapy.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
10/18. Malignant fibrous histiocytoma metastatic to the thyroid gland.Despite frequent cancer metastases to the thyroid gland demonstrated at autopsy, finding of thyroid metastasis in clinical practice is rare. Malignancies most commonly metastasizing to the thyroid are malignant melanoma and carcinoma of the breast, kidney, and lung. Very little is known about thyroid metastases caused by sarcomas. Of these, malignant fibrous histiocytoma (MFH) is one of the most common in adults, with a high rate of metastases. A case of clinically significant thyroid metastasis from primary MFH involving the thigh visualized on I-123 thyroid imaging is reported.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
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