1/9. A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection.Hepatitis A infection is known to induce autoimmune hepatitis and autoimmune hemolytic anemia. Here we present a case with autoimmune hepatitis type I and autoimmune hemolytic anemia following hepatitis a virus (HAV) infection. Case: M.A., a male patient, was brought to the hospital with complaints of jaundice and malaise. physical examination revealed paleness and icterus. The liver was palpable 5 cm below the costal margin in the midclavicular line; the spleen was palpable 2 cm from the costal margin. Laboratory examination revealed severe anemia, reticulocytosis and direct Coombs' IgG positivity. liver enzymes, total and conjugated bilirubin and alkaline phosphates levels, total protein and immunglobulin levels were high and prothrombin time elongated. Hepatitis A IgM antibody was found positive, while other hepatitis serologic markers were negative. Anti-smooth muscle antibody (ASMA) was positive in 1/80 titer. With these laboratory findings, the case was diagnosed as autoimmune hepatitis and autoimmune hemolytic anemia induced by hepatitis A infection. liver histology also supported the diagnosis. Steroid therapy resulted in clinical and laboratory remission. In conclusion, it is important to vaccinate children against hepatitis A infection to protect them from its complications and also from autoimmune diseases induced by this infection.- - - - - - - - - - ranking = 1keywords = hemolytic (Clic here for more details about this article) |
2/9. Severe haemolysis associated with hepatitis A and normal glucose-6-phosphate dehydrogenase status.We report massive acute haemolysis associated with hepatitis A in a 36 year old Irish woman. Although mild anaemia is not uncommon during viral hepatitis, haemolysis of the severity observed in this patient has previously been reported only in patients with glucose-6-phosphate dehydrogenase deficiency.- - - - - - - - - - ranking = 0.06267462379857keywords = anaemia (Clic here for more details about this article) |
3/9. Severe erythroblastopenia and hemolytic anemia during a hepatitis A infection.A 41-year-old woman had acute hepatitis A infection complicated with severe anemia due to selective erythroblastopenia and hemolysis. A mechanism involving a cellular immune reaction is suggested. The hematological complications resolved during steroid treatment. She later developed a transient seropositive arthritis.- - - - - - - - - - ranking = 0.57142857142857keywords = hemolytic (Clic here for more details about this article) |
4/9. Severe aplastic anaemia following hepatitis A.A 3-year-old child developed severe aplastic anaemia following hepatitis A. Since no HLA-compatible donor was available, he was treated with oxymetholone, antithymocytic globulin and methylprednisolone, but no haematologic recovery was observed and he consequently died of pneumonia. Although the association of aplastic anaemia and hepatitis A has already been recognized, this patient represents the first case of aplastic anaemia in which the previous hepatitis A has been well documented.- - - - - - - - - - ranking = 0.43872236658999keywords = anaemia (Clic here for more details about this article) |
5/9. autoimmunity in chronic lymphocytic leukaemia.Seventy-nine patients with chronic lymphocytic leukaemia were evaluated for the presence of autoimmune diseases and autoantibodies. One patient has polymyositis and two additional patients presented with features suggestive of pernicious anaemia and chronic active hepatitis. The Coombs' direct test was positive in 7% and immune thrombocytopenia was present in 8.1% of patients. Five (7%) patients had M-protein in the serum. No increased frequency of other autoantibodies was noted in our study group. We conclude that the propensity to develop antibodies is restricted only to the haematopoietic system and that there is no increased frequency of non-haematological autoimmune diseases in chronic lymphatic leukaemia.- - - - - - - - - - ranking = 0.06267462379857keywords = anaemia (Clic here for more details about this article) |
6/9. Aplastic anaemia complicating hepatitis a virus infection.We report three patients with aplastic anaemia complicating hepatitis a virus infection. The pathogenesis and management of this rare complication which usually carries a poor prognosis, are briefly discussed.- - - - - - - - - - ranking = 0.31337311899285keywords = anaemia (Clic here for more details about this article) |
7/9. Acute auto immune haemolytic anaemia secondary to hepatitis A infection.Auto immune haemolytic anaemia has been described in association with a variety of hepatotropic viruses, in particular cytomegalovirus, Epstein-Barr virus and hepatitis b. There is a well-recognized association between chronic active hepatitis and auto immune haemolytic anaemia. We present the first reported case of acute hepatitis A which resulted in a fall in haemoglobin concentration from 14.6 to 4.5 g/dl due to an acute haemolytic anaemia with an associated rise in bilirubin from 149 to 960 mumol/l.- - - - - - - - - - ranking = 0.43872236658999keywords = anaemia (Clic here for more details about this article) |
8/9. Coombs-negative severe hemolysis associated with hepatitis A.Mild anemia can occasionally be observed during viral hepatitis, but severe hemolysis has previously only been reported in a few patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a case of massive acute hemolysis associated with an acute hepatitis A in a 39-year-old woman in the absence of G6PD-deficiency. The patient was also suffering from mild rheumatoid arthritis. All known factors responsible for hemolysis were ruled out. Although tests for autoimmune hemolytic anemia were negative the patient made a dramatic recovery after treatment with corticosteroids, suggesting an immune mediated mechanism nonetheless.- - - - - - - - - - ranking = 0.14285714285714keywords = hemolytic (Clic here for more details about this article) |
9/9. Hepatitis A and cytomegalovirus infection precipitating acute hemolysis in glucose-6-phosphate dehydrogenase deficiency.A 34-year-old man presented with acute hemolytic anemia secondary to acute viral hepatitis A and a coexisting acute cytomegalovirus infection. This association has not been described previously in patients with glucose-6-phosphate dehydrogenase deficiency and is the subject of this report.- - - - - - - - - - ranking = 0.14285714285714keywords = hemolytic (Clic here for more details about this article) |