1/17. Fine-needle aspiration cytology of malignant hemangiopericytoma of the salivary gland: A case report.A 79-yr-old woman presented with a 5-yr history of swelling of the left cheek. The fine-needle aspiration (FNA) smear showed a spindle-cell neoplasm with capillaries and benign endothelial cells. The spindle cells possessed pleomorphic, hyperchromatic elongated nuclei and a moderate amount of ill-defined cytoplasm. They also showed papillary arcades surrounded and encased by relatively small ovoid to short spindle cells. Subsequent surgical excision confirmed the presence of malignant hemangiopericytoma (HP). Immunohistochemical studies on the histologic section using vimentin were strongly positive, consistent with HP. To the best of our knowledge, this is the second published report of FNA cellular features of malignant HP of the salivary gland. Besides delineating the FNA cellular features of HP of the salivary gland, the present case illustrates the value of using immunohistochemical approaches. Diagn. Cytopathol. 1999;21:398-401.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/17. Fine-needle aspiration cytology of hemangiopericytoma: report of two cases.The fine-needle aspiration biopsy (FNAB) findings in two cases of hemangiopericytoma (HP), arising in the parotid gland and on the inner chest wall, respectively, are reported. Smear preparations in each case showed cytologic features of an undifferentiated spindle-cell neoplasm, whereas a core needle biopsy specimen of the chest wall mass showed a spindle-cell tumor with a "staghorn-like" arrangement of endothelium-lined vascular channels. Immunostains performed on this core biopsy, and on the surgical resection specimens in both cases, showed positive staining of tumor cells for vimentin and CD34, with negative staining for a variety of smooth muscle, epithelial, neural, and neuroendocrine markers. Electron microscopy performed in one case further supported the diagnosis of HP. With adequate sampling and appropriate use of ancillary studies, a diagnosis of HP can be reliably suggested on the basis of FNAB and core biopsy of a soft-tissue mass.- - - - - - - - - - ranking = 0.16666666666667keywords = gland (Clic here for more details about this article) |
3/17. Haemangiopericytoma of infratemporal fossa.Haemangiopericytomas (HPCs) are rare vascular tumours that commonly involve the soft tissues of the trunk and lower extremities. In the head and neck, the most common sites are the nasal cavity and the paranasal sinuses, and unusually, the orbital region, the parotid gland, and the neck. We report a patient with HPC that originated in the infratemporal fossa and involved the pterygopalatine and the middle cranial fossae, apparently the first such case to be reported. Although the patient has undergone resection on three separate occasions, the tumour recurred. We then performed an extended resection using the infratemporal fossa approach type D. The patient has shown no recurrence in the past five years. Although histopathologic confirmation of this malignancy may be difficult, extensive resection remains the most effective treatment in such cases.- - - - - - - - - - ranking = 0.16666666666667keywords = gland (Clic here for more details about this article) |
4/17. hemangiopericytoma of the parotid gland: CT and MR features.Hemangiopericytomas are uncommon vascular neoplasms with rare occurrence in the head and neck region. They originate from the pericytes, which are small, oval cells encircling capillaries. Hemangiopericytomas traditionally appear in the retroperitoneum and in the capillaries of the extremities. A case of hemangiopericytoma of the parotid gland is presented. The clinical, surgical, histologic, and radiologic features are described and discussed.- - - - - - - - - - ranking = 0.83333333333333keywords = gland (Clic here for more details about this article) |
5/17. Vanek's tumor (inflammatory fibroid polyp). Report of 18 cases and comparison with three cases of original Vanek's series.Eighteen cases of Vanek's tumors are presented. The patients included nine men and nine women between the ages of 45 and 93 years (mean, 66.2 years). Nine cases were clinically diagnosed as polyps of the gastric antrum, five cases as polyps of the stomach (not otherwise specified), one polyp was located in the ileum and the three remaining polyps in the small intestine (not otherwise specified). The thirteen polyps with available size information measured from 0.4 to 5 cm in the greatest diameter (mean, 2.2 cm). Immunohistochemically, the affections were positive for vimentin (18/18) and CD34 (15/18). All the cases negative for CD34 also lacked concentric onion skin-like formations of the spindle cells around glands and vessels. The different immunophenotype and absence of concentric formations could be explained by the existence of two different lesions commonly designated as Vanek's tumor (inflammatory fibroid polyp) or by the hypothesis of various evolutional stages. In the differential diagnosis, it is important to distinguish namely eosinophilic gastroenteritis, gastrointestinal stromal tumor, inflammatory pseudotumor, hemangioendothelioma, and hemangiopericytoma. In contrast to gastrointestinal stromal tumors, genetically no substitution, deletion, or insertion occurred in c-kit exon 11 in all analyzed samples. Likewise, no deletion or insertion in part of c-kit exon 9 was observed.- - - - - - - - - - ranking = 0.16666666666667keywords = gland (Clic here for more details about this article) |
6/17. Haemangiopericytoma of the thyroid gland in combination with Hashimoto's disease.We present a hitherto unique case of haemangiopericytoma (HP) of the thyroid gland in a 15-year-old female patient suffering from Hashimoto's disease for several months. Since angiogenesis has been discussed to play a major role in both diseases, we examined the expression of vascular endothelial growth factor (VEGF), VEGF receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs). Most interestingly, strong expression of PDGFR alpha and beta was found in spindle-shaped tumour cells and tumour vessels in HP, while VEGF and VEGFR type I and -II were negative in these regions. In contrast, VEGF was expressed in the lymphoid infiltrate of Hashimoto's disease. Since PDGFR-beta is commonly expressed in pericytes, we suggest that the strong expression discovered in this study further supports the view that HP is derived from pericytes. The combination of HP and Hashimoto's disease is most probably a coincidental event. However, this case confirms previous reports demonstrating that in patients with Hashimoto's disease different neoplasias can occur.- - - - - - - - - - ranking = 0.83333333333333keywords = gland (Clic here for more details about this article) |
7/17. Primary haemangiopericytomas of the parotid gland.Haemangiopericytomas involving the parotid gland are uncommon and those arising from the gland itself are rare. Three examples of primary parotid gland hemangiopericytoma are presented. The biological course of parotid or periparotid haemangiopericytomas does not differ from that manifested by their counterparts arising from somatic soft tumours.- - - - - - - - - - ranking = 1.1666666666667keywords = gland (Clic here for more details about this article) |
8/17. hemangiopericytoma-like synovial sarcoma of the lumbar spine. Case report.The purpose of this report is to demonstrate that synovial sarcoma should be included in the differential diagnosis of tumors originating from the lumbar spine, especially if they show hemangiopericytoma-like pathological characteristics. A synovial sarcoma is a mesenchymal spindle cell tumor that displays variable epithelial differentiation including glandular formation. It is unrelated to a synovium. More than 80% of these lesions arise in the deep soft tissue of the extremities. The tumor frequently arises adjacent to joints or tendon sheaths. The authors describe a young woman with a hemangiopericytoma-like tumor of the lumbar spine. During repeated operation, this lesion was shown to be a synovial sarcoma, which had invaded the dura mater. The tumor metastasized to the mediastinum and the intradural cervical spine and, finally, to the brain and the lungs. To the authors' knowledge, this is the first reported case of a synovial sarcoma originating from the lumbar spine.- - - - - - - - - - ranking = 0.16666666666667keywords = gland (Clic here for more details about this article) |
9/17. The cells of benign and malignant hemangiopericytomas in aspiration biopsy.Samples obtained by fine-needle biopsy of two benign and one malignant hemangiopericytoma revealed tumor cells with round, oval, or spindle-shaped nuclei, with variable and ill-defined filmy cytoplasm. The nuclei had a finely granular chromatin pattern with or without inconspicuous nucleoli. They were seen singly or in loose or dense cellular clusters. Focal gland-like arrangement of tumor cells was noted in some cellular clusters. Benign endothelial cells were seen among tumor cells and were not cohesive to the latter. The benign and malignant nature of hemangiopericytoma cannot be predicted by examination of the cells present in the aspirates. Also, a specific diagnosis of hemangiopericytoma could not be made on cytologic basis alone as cells of hemangiopericytoma were difficult to differentiate from those of other spindle-cell mesenchymal tumors.- - - - - - - - - - ranking = 0.16666666666667keywords = gland (Clic here for more details about this article) |
10/17. Malignant hemangiopericytoma with admixed glandular structures in breast and lung metastases. A light and electron microscopic and histochemical study of a case.A 29-year-old woman with a malignant retroperitoneal hemangiopericytoma which metastasized to both breasts and the lung, is reported. The metastases in the breasts and the lung included numerous glandular structures. The light and electron microscopic, and histochemical analysis confirmed the diagnosis of hemangiopericytoma, and indicated that the glandular component was not a true part of the neoplasm but preformed glandular structures were included. The findings are discussed in relation to previous reports on low-grade leiomyosarcoma with glandular formation in lung metastases. The differential diagnosis against synovial sarcoma, which in monophasic forms may show a prominent pericytoma-like pattern, and in biphasic forms includes pseudoglandular structures, is discussed.- - - - - - - - - - ranking = 1.5keywords = gland (Clic here for more details about this article) |
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