1/9. granular cell tumor of the common bile duct: a case report.Granular cell tumors (GCTs) are uncommon soft tissue tumors, usually presenting in the skin and subcutaneous tissue tongue and oral cavity. We present a case report of granular cell tumor of the common bile duct involving both extra- and intrapancreatic portions. The histogenesis appears to be related to schwann cells, similar to granular cell tumors of other sites, as evidenced by histologic and immunohistochemical findings. review of the English literature concerning biliary tract GCTs revealed a high occurrence in African-American females in their third decade. By-pass operation to correct the biliary tract obstruction may be appropriate, if the nature of the tumor can be obtained from intraoperative diagnosis by frozen section.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/9. Multiple granular cell tumors of the gastrointestinal tract with subsequent development of esophageal squamous carcinoma.A 52-year-old woman initially presented to our medical center with synchronous, submucosal tumors of the esophagus, stomach, and transverse colon. The gastric and colonic tumors were resected, and both displayed infiltrating sheets of polygonal cells with coarsely granular cytoplasm and small vesicular nuclei. The neoplastic cells of both tumors were immunoreactive for S-100 protein. Ultrastructural studies revealed the lysosomal nature of the cytoplasmic granules. Although the esophageal mass was not resected, it was felt that this represented another focus of granular cell tumor of the gastrointestinal tract. Two years later, she presented with disseminated squamous carcinoma of the esophagus. At autopsy, a submucosal granular cell tumor was found adjacent to the squamous carcinoma of the esophagus. To our knowledge, this is the first reported case of synchronous granular cell tumors that involved multiple segments of the gastrointestinal tract, one of which was later associated with a squamous carcinoma of the esophagus.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/9. Cerebral granular cell tumors: report of a case and a note on their nature and expected behavior.A case of cerebral granular cell tumor (GCT) is reported. Histologically, the growth was composed of benign astrocytes, granular cells and transitional forms between both elements. glial fibrillary acidic protein was detected in the glial component and, to a lesser extent, in the granular cells. Alpha-1-antichymotrypsin was demonstrated in the latter component only. Ultrastructural study also supported the evidence that neoplastic astrocytes became granular cells. The survey of the literature and our own results suggest that GCTs in this particular location, even when histologically benign, seem to have a worse prognosis than the low-grade supratentorial astrocytomas.- - - - - - - - - - ranking = 4keywords = nature (Clic here for more details about this article) |
4/9. Primitive nonneural granular cell tumors of skin: clinicopathologic analysis of 13 cases.A rare subset of distinctive cutaneous nonneural granular cell tumors was described by LeBoit et al in 1991 and termed "primitive polypoid granular-cell tumor." Herein, we report our experience with 13 similar, distinctive nonneural granular cell tumors. Affected patients included 7 males and 6 females ranging in age from 5 to 83 years (mean, 25 years; median, 16 years). These cutaneous lesions involved the back (5 cases), neck, shoulder, thigh (2 cases each), chin, and elbow (1 case each). Clinically described as smooth, nontender cutaneous nodules, the tumors ranged in size from 0.2 to 2.8 cm (median, 0.8 cm) and were present from months to years before excision. Mitoses numbered from 1 to 6 per mm (median, 2). Eight of the lesions were polypoid, based in the papillary dermis with extension to the superficial dermis and associated with an epithelial collarette. Five of the lesions were situated deeper in the reticular dermis with limited extension into the subcutis but clinically were also nodular. All the tumors were well circumscribed and composed of spindled to ovoid cells with abundant granular, eosinophilic cytoplasm and vesicular nuclei with small prominent nucleoli. immunohistochemistry revealed reactivity only for NKI-C3 (11 of 12 cases), CD68 (7 of 11 cases), and NSE (5 of 10 cases); S-100 protein as well as other melanocytic, epithelial, and myoid markers were uniformly negative. All 13 of the lesions were locally excised and in the 8 cases with adequate follow-up ranging from 13 to 126 months (mean, 68 months; median, 41 months), none has recurred locally. However, one tumor (case no. 11) gave rise to a local lymph node metastasis 25 months after presentation, but the patient is currently disease-free 70 months after lymphadenectomy. These cutaneous granular tumors do not appear to be neural or Schwannian in nature, but their precise line of differentiation is unknown.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/9. Granular cell tumour of the neurohypophysis.Granular cell tumours of the neurohypophysis are very rare. Their aetiology and nature are uncertain. Most investigators consider them to arise from pituicytes or schwann cells of the posterior lobe of the hypophysis. They are found most commonly in older people. A surgically proven symptomatic case is reported.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/9. granular cell tumor of penis and scrotum.Two cases of granular cell tumor of the external male genitalia are reported: one on the scrotum and one on the shaft of the penis. No previous reports of granular cell tumor of the scrotum appear in the literature. Each tumor was treated by simple excision and there was no recurrence. Each tumor showed cytoplasmic S-100 positivity. Tumor was seen in close proximity to small nerve fibers, sweat glands, and erectile smooth muscle. These findings are considered encroachments rather than evidence of origin from any of these structures. An immunohistochemical signature for granular cell tumor has developed in recent years, but, from a practical viewpoint, only the S-100 stain should be used for confirmation of the diagnosis.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/9. Granular cell myoblastoma involving multiple organs.We have described a rare case of multifocal granular cell myoblastoma affecting respiratory and hepatobiliary tracts in a young woman. The patient had successful tracheal resection and biliary stent placement to alleviate symptoms. Long-term follow-up will clarify the true nature of the disease.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
8/9. Malignant granular cell tumor. Report of a case with dna ploidy analysis.Malignant granular cell tumor is a rare neoplasm that has been reported to occur at various sites. Although there are no reliable histologic criteria to differentiate the benign from the malignant form of granular cell tumor, in many reported cases cellular pleomorphism and the presence of mitotic activity suggested an aggressive nature. We report a case of malignant granular cell tumor that involved the subcutaneous tissue in the sacrococcygeal area. The tumor showed cellular atypia on histologic sections, but mitotic figures were rare. The tumor recurred and produced widespread metastasis, resulting in the death of the patient. dna flow cytometry demonstrated dna diploidy, suggesting that such analysis may not be beneficial in predicting the behavior of these tumors.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
9/9. Granular cell myoblastoma. review of the literature and report of a case.The origin and nature of granular cell myoblastoma (GCM) have been debated since the original description of a granular cell tumor by Abrikossoff in 1926. Many cell types have been implicated in its histogenesis, including muscle cells, histiocytes, fibroblasts, neural sheath cells and undifferentiated mesenchymal cells, but the origin of the lesion remains still controversial. The authors present a review of the clinical features and the histopathologic and histochemical findings of this nebulous entity. They also report a case of granular cell myoblastoma of the tongue.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |