1/14. Papillary thyroid carcinoma with nodular fasciitis-like stroma. Pitfalls in fine-needle aspiration cytology.Papillary thyroid carcinoma with nodular fasciitis-like stroma is one of the rare variants of papillary thyroid carcinoma. The problems posed by the exuberant nodular fasciitis-like stroma, which obscures the neoplastic nature of the tumor, are recognized in surgical pathology but have received little attention in the cytopathology literature. We report a rare case of papillary thyroid carcinoma in which nodular fasciitis-like stroma posed difficulty on fine-needle aspiration cytology. The differential diagnosis of fibroproliferative processes in thyroid fine-needle aspirations is also discussed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/14. Eosinophilic fasciitis treated with psoralen-ultraviolet A bath photochemotherapy.Eosinophilic fasciitis is a rare disorder which can markedly affect the quality of life in individual patients. So far, no generally accepted and effective treatment modality has been available. Although the precise nature of eosinophilic fasciitis is still unknown, it is often regarded as a variant of localized scleroderma (morphoea). phototherapy and photochemotherapy have been shown to be effective in the treatment of sclerodermatous skin lesions. We report a patient with eosinophilic fasciitis which was successfully treated with psoralen plus ultraviolet A bath photochemotherapy within 6 months.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/14. Nodular fasciitis presenting as a parotid tumour after face lifting.Nodular fasciitis, a benign, pseudosarcomatous proliferative lesion of the soft tissue, is frequently misinterpreted as a sarcoma, both clinically and microscopically. Lesions associated with the parotid gland have been very rarely reported. We report a case of nodular fasciitis mimicking a parotid tumour after a facelift. We performed histological and immunohistochemical study and CT scan for it is difficult to make a differential diagnosis. We confirmed the final diagnosis as intraparotid nodular fasciitis. Superficial parotidectomy was performed because of initial pathological misdiagnosis reported as a dermatofibroma. The subsequent diagnosis was confirmed to be nodular fasciitis on the basis of immunohistochemical study. There was no recurrence after follow-up to 18 months. Proper diagnosis of nodular fasciitis in the parotid region and early recognition of its benign nature are necessary to differentiate it from other various benign and malignant tumours of the parotid gland.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/14. Atypical decubital fibroplasia with unusual histology.A case of atypical decubital fibroplasia with unusual histology arising in the buttock of a 68-year-old bed-ridden male in presented. The lesion measuring 5.4 cm in greatest dimension was histologically characterized by a proliferation of fibroblasts with oval to spindle nuclei and dense fibrous stroma with focal hyalinization and calcification. Ganglion-like fibroblastic cells and multinucleated giant cells of osteoclast type were also observed. There were numerous elastic fibers within and adjacent to the proliferating stromal cells. The proliferating stromal cells were positive for vimentin and collagen type iv but negative for CAM 5.2, epithelial membrane antigen, desmin, alpha-smooth muscle actin, muscle actin, HHF35, S-100 protein and CD34. Ultrastructurally, they were of a fibroblastic nature. The hypercellularity, lack of zones of fibrinoid necrosis, lack of lobulation and the presence of multinucleated giant cells were different from the originally described lesion. This condition represents a variant of atypical decubital fibroplasia. Pathogenic factors of this lesion are considered to be chronically repeated pressure and associated intermittent ischemia. The recognition of the lesion and its distinction from a sarcoma is essential.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/14. Retroperitoneal necrotizing fasciitis.Necrotizing fasciitis is a mixed infection of the skin and subcutaneous tissues with a characteristic clinical and pathological appearance. Early radical surgical excision of all affected tissue is the treatment of choice. In a series of 19 patients with necrotizing fasciitis, bacteriological assessment in 15 confirmed the mixed nature of the infection, with bacteroides sp. isolated from ten patients. All 12 patients who underwent radical surgical excision survived. A subgroup of patients was identified in whom the appearance of necrotizing fasciitis in the abdomen or perineum was indicative of more extensive disease in the retroperitoneal tissues. Surgical resection of all affected tissue was not feasible in these cases and the outcome was uniformly fatal, giving an overall mortality rate for the series of 37 per cent.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/14. Nodular fasciitis of the head and neck.Nodular fasciitis is an unusual benign reactive process affecting superficial and deep fascia. Its rapid growth, rich cellularity, high mitotic activity and poorly circumscribed nature result in it being easily misdiagnosed as a sarcomatous lesion. Three cases of nodular fasciitis presenting as neck lumps are reported. They were successfully treated with local excision, with no signs of recurrence following two years of follow up. This paper describes the clinical presentation and microscopic features of this rare benign lesion and it emphasizes the need for accurate histopathology and clinical suspicion, if inappropriate aggressive management is to be avoided.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/14. A case of nodular fascitis of the breast and review of the literature.Nodular fascitis is a benign condition commonly affecting the limbs. In the breast, however, it may mimic breast Cancer clinically and radiologically. We report a case of nodular fascitis of the breast and its conservative management. With the use of cytology, core biopsy and imaging we were able to confidently diagnose nodular fascitis and, therefore, avoid surgical intervention. Recent literature is reviewed demonstrating the benign nature of this disease.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
8/14. colitis and pericarditis in a patient with eosinophilic fasciitis. A contribution to the multisystem nature of eosinophilic fasciitis.A case of eosinophilic fasciitis (EF), associated with monoclonal gammopathy, thyroglobulin antibodies, pericarditis and colitis, is described. The occurrence of EF in the framework of a multisystem disease is the outstanding feature, contrasting with the absence of visceral involvement or solitary organ involvement in the large majority of cases. The unusual histologic features of the colitis and beneficial effect of cimetidine on EF are discussed.- - - - - - - - - - ranking = 4keywords = nature (Clic here for more details about this article) |
9/14. Necrotizing fasciitis of the vulva during chemotherapy.A case of necrotizing fasciitis of the vulva arising in a leukemic patient during a chemotherapy nadir is presented. The nature of the process was not recognized initially, and the patient was treated with intravenous antibiotics. After clinically evident necrosis developed, prompt surgical debridement was carried out. Clinical improvement followed and the wound healed well. This case suggests that chemotherapy with its attendant immunosuppression is a predisposing factor in the development of necrotizing fasciitis and warrants a high index of suspicion.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
10/14. Clostridial sepsis: unusual clinical presentations.We present four cases exhibiting the widely diverse nature of clinical infections due to anaerobic clostridium perfringens. These cases exemplify the need for a thorough initial physical examination, immediate Gram staining of fluid from involved tissue, and recognition of the severity of the disease in any patient who has early septic deterioration after elective or emergency surgical procedures. Management of these infections includes both high-dose parenteral penicillin therapy and aggressive initial surgical debridement of all involved tissues.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
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