1/4. Misleading cause of acute arterial insufficiency: ergotamine intoxication. Case report.In a woman arteriographically indicated spasm of the iliac, femoral and popliteal arteries did not respond to intra-arterial tolazoline. At operation groin pulsations were normal. Bilateral lumbar sympathectomy was performed. Subsequently it emerged that she had been using ergotamine. Surgery could have been avoided if nitroprusside had been given.- - - - - - - - - - ranking = 1keywords = intoxication (Clic here for more details about this article) |
2/4. ergotism as a consequence of thromboembolic prophylaxis.Vasospasm related to ergot intoxication is unusual. The authors report the case of 15-year-old boy who developed vasospasm necessitating amputation, due to an ergot derivative prescribed for thromboembolic prophylaxis. The importance of prompt angiographic recognition and therapy is stressed.- - - - - - - - - - ranking = 0.25keywords = intoxication (Clic here for more details about this article) |
3/4. Ergot poisoning in paraplegia.Ergot derivatives are widely used for migraine headaches. However, ergotamine tartrate may cause intoxication which may even become fatal. A case of ergot poisoning in a paraplegic patient is reported, where deep vein thrombosis and ischaemia of the lower limbs were the presenting signs.- - - - - - - - - - ranking = 0.25keywords = intoxication (Clic here for more details about this article) |
4/4. Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction.The macrolide class of antibiotics, including erythromycin and troleandomycin, is associated with clinically significant adverse drug interactions. This results from macrolide inhibition of cytochrome P-450 metabolism of numerous xenobiotics, resulting in elevated serum drug levels and clinical intoxication. Animal studies, however, suggest that clarithromycin, the newest approved macrolide antibiotic, has has less potential for adverse drug reactions. We describe a patient who, on her fifth day of clarithromycin therapy, developed clinical ergotism (i.e., hypertension, lingual ischemia, and peripheral cyanosis) several hours after administration of her usual 2-mg dose of ergotamine tartrate. To our knowledge, this is the first report of clinical ergotism precipitated by clarithromycin-ergotamine interaction and suggests that, like other macrolide antibiotics, ergot preparations should be avoided in patients who are taking clarithromycin.- - - - - - - - - - ranking = 0.25keywords = intoxication (Clic here for more details about this article) |