1/5. A case of severe pituitary dwarfism associated with prolactin and thyroid stimulating hormone deficiencies.An extreme dwarf 10-year-old boy was described. His clinical features resemble those of isolated GH deficiency type 1A, but the Southern blot analysis showed no gross deletion in the GH structural gene. Endocrinological evaluations showed severe GH and PRL deficiencies, and mild TSH deficiency. The simultaneous deficiencies of anterior pituitary hormones in our patient resemble those of the Snell and Ames dwarf mice and suggest a common etiology. The evolutionary and embryological similarities between GH and PRL imply that mutations at a gene which controls GH and PRL production in somatotropes and lactotropes or at a gene of which product affects the embryological development from a common ancestral cell in the anterior pituitary gland may be a primary defect in our patient.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/5. Ectopic posterior lobe of the pituitary gland and intractable nocturnal enuresis in a case with pituitary dwarfism.An 11 5/12-year-old girl with pituitary dwarfism had intractable nocturnal enuresis. magnetic resonance imaging revealed pituitary stalk transection and the formation of an ectopic posterior lobe. The results of responses to dehydration, infusion of hyperosmolar NaCl solution, and 1-desamino-8-D-arginine vasopressin showed that the nocturnal enuresis in the present case was due to a partial vasopressin deficiency. We suggest that the ectopic posterior lobe is one cause of nocturnal enuresis.- - - - - - - - - - ranking = 4keywords = gland (Clic here for more details about this article) |
3/5. Evidence of polyglandular involvement in Niemann-Pick disease type B.We report a girl with Niemann-Pick disease type B in whom short stature was recorded over a long period. association of short stature with the presence of a polyglandular involvement in this patient is discussed.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
4/5. Morning glory syndrome in children. association with endocrine and central nervous system anomalies.OBJECTIVE: To identify morning glory syndrome, an uncommon optic disc anomaly. Generally, it is an isolated ocular abnormality; however, some cranial facial and neurologic associations have been reported. patients: We herein report two patients with morning glory syndrome and associated pituitary dwarfism. In one patient, the pituitary insufficiency was secondary to compression of the pituitary gland by a basal encephalocele; in the second patient, causative factors were not identified. CONCLUSIONS: patients with morning glory syndrome should have a complete general physical examination and growth evaluation so that early recognition and treatment of the patient with pituitary dwarfism can occur.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
5/5. Secondary pituitary insufficiency: report of three cases of ectopia or hemiagenesis of the thyroid gland.Three patients with clinical and laboratory manifestations suggestive of pituitary insufficiency due to the presence of a pituitary tumor were found to have long-standing myxedema. The insidious appearance of the signs of hypothyroidism was explained by the cause of their disease--an ectopic thyroid gland in two patients and hemiagenesis of the thyroid in the third. Early recognition and treatment of such cases is important.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |