1/4. Pimecrolimus: a new treatment for seborrheic dermatitis.Seborrheic dermatitis is a chronic recurrent inflammatory skin condition that mainly affects areas containing sebaceous glands. I present a case of a novel effective topical nonsteroidal treatment (pimecrolimus 1.0% cream) for facial seborrheic dermatitis. Pimecrolimus is a member of a new class of nonsteroidal agents- macrolactam immunomodulators.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/4. Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production.BACKGROUND: Zileuton, a 5-lipoxygenase inhibitor, reduces the number of inflammatory lesions in moderate acne and inhibits the synthesis of sebaceous lipids. OBJECTIVE: To detect whether zileuton directly reduces sebum synthesis. methods: A 40-year-old female with mild disseminated sebaceous gland hyperplasia and seborrhea was treated with zileuton 4 x 600 mg/day over 2 weeks, was followed-up for 6 weeks after discontinuation of zileuton and was re-treated with low-dose isotretinoin 10 mg/2nd day over 5 weeks. Casual skin surface lipids and sebum synthesis were determined. RESULTS: Under treatment with zileuton increased casual skin surface lipids were normalized and synthesis of facial sebum was decreased. Six weeks after discontinuation of treatment casual skin surface lipids were increased again and synthesis of sebum returned to baseline. Subsequent low-dose isotretinoin treatment led to similar changes of casual skin surface lipids and sebum synthesis with zileuton already after 2 weeks. CONCLUSION: Zileuton directly inhibits sebum synthesis in a transient manner with a potency similar to low-dose isotretinoin at least in our patient.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
3/4. Simultaneous occurrence of idiopathic lipemic tears and massive seborrhea.A 42-year-old man had idiopathic lipemic tears and massive seborrhea. Recent investigations have shown that cholesterol and other lipids occasionally found in tears are produced by meibomian rather than lacrimal glands. The finding in this patient of hypersecretion by both sebaceous glands and meibomian glands, a sebaceous gland variant, suggests that a common mechanism may regulate secretory control of both of these glands.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
4/4. Areolar gland discharge in adolescent females.Two Tanner stage IV adolescent females with secretion of material from the areolar glands of the breast are described. This report, as well as previous case reports, indicates that the condition is benign in the presence of an otherwise unremarkable physical examination. In contrast to galactorrhea, which must be evaluated completely, areolar gland discharge appears to be a curiosity that may be as rare as the number of case reports would suggest. It appears to warrant nothing more than careful observation.- - - - - - - - - - ranking = 6keywords = gland (Clic here for more details about this article) |