1/5. Contextual analysis complements single-cell analysis in the diagnosis of breast cancer in fine needle aspirates.Image analysis techniques were used to characterize individual nuclei of cells and entire clusters of cells in hematoxylin-and-eosin-stained smears of fine needle aspirates of the breast to determine the ability of these techniques to distinguish benign from malignant cases. Analysis of the individual nuclear features showed significant differences in nuclear area, shape (bending energy), texture and integrated darkness between benign and malignant samples. Analysis of the clusters demonstrated that the benign clusters were fewer in number, more cellular (average gray level) and larger than malignant clusters. A statistical classifier was constructed to test the discriminatory accuracy for benign and malignant cases. Good discrimination was found for both the individual nuclei and the clusters when analyzed separately, although a few cases were misclassified by each type of analysis. When combined, the two classifiers achieved a completely accurate classification. This suggests the complementary nature of high-resolution single-cell analysis and the more global cluster analysis techniques.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/5. Benign nevus cells in the lymph nodes. An immunohistochemical study.Aggregates of nevus cells in the axillary lymph nodes may give rise to a suspicion of metastatic breast cancer. Usually the nevus cells are confined to the capsule or the trabeculae, but in the present case, clusters of nevus cells were also observed in the peripheral sinus. Immunohistochemical analysis for S-100 protein and epithelial membrane antigen established the true nature of the cells.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/5. fibroadenoma of the female breast with multinucleated giant cells.A fibroadenoma in the female breast is described, which contained multiple multinucleated giant cells within the stroma. The investigation indicated the giant cells to be of epithelial nature, caused by epithelial degeneration secondary to myoepithelial swelling of unknown cause. Their presence and morphology could cause anxiety about malignancy, but this was found groundless.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/5. Bilateral papillary adenofibroma of the fallopian tube.A unique case of bilateral papillary adenofibroma of the fallopian tube is reported. The seven-year disease-free follow-up after simple excision without salpingectomy further confirms the benign nature of this entity.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/5. Papillary adenofibroma of the uterine cervix. A case report.Papillary adenofibroma of the uterine cervix is a rare benign neoplasm with histologic characteristics similar to the ovarian adenofibroma. We report the case of a 46 years old patient who suffered menorrhagia. At colposcopic exam a polypoid neoformation was seen at the cervix uteri which was diagnosed as endocervical polyp and polypectomy followed. Only the histologic exam revealed the true nature of the tumor.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |