Rare congenital deformity syndrome characterized by a combination of five anomalies as a result of neural tube defect. The five anomalies are a midline supraumbilical abdominal wall defect (e.g., OMPHALOCELE), a lower sternum defect, a congenital intracardiac defect, an anterior diaphragm defect, and a diaphragmatic pericardium defect (e.g., pericardial effusion). Variants with incomplete and variable combinations of the defects are known. ectopia cordis; cleft lip; and cleft palate are often associated with the syndrome.