1/370. Intramuscular mixed tumour with clonal chromosomal changes. A case of an entirely intramuscular mixed tumour occurred in an 82-year-old man, who presented with a large mass in the region of the right triceps muscle. A lobulated tumour was seen, with plump, round epithelioid cells embedded in a chondromyxoid stroma. Immunohistochemical examination showed strong S100 protein and pancytokeratin positivity in most of the tumour cells. cytogenetic analysis revealed complex clonal chromosomal changes: 47, XY, i(2) (q10), -15, der(17) t(15; 17) (q11; p12), r. Differential diagnosis against extraskeletal myxoid chondrosarcoma (EMC) may be problematic, particularly in an incisional biopsy. Chromosomal analysis can be very helpful in solving this problem, since EMC shows a specific reciprocal chromosome translocation characterised as t (9;22) (q22-31) (q11-12). ( info) |
| We report, for the first time, the cytogenetic and molecular genetic constitution of a human mesenchymoma. As in several other soft tissue sarcomas, supernumerary ring and rod-shaped marker chromosomes were observed next to an otherwise normal diploid karyotype. Comparative genomic in situ hybridization and whole chromosome painting experiments revealed that chromosome 1q21-q25 and 12q14-q15 sequences were amplified, and that these sequences resided on the supernumerary marker chromosomes. We assume that, in this malignant mesenchymoma, the observed chromosomal anomalies may be associated with its well differentiated liposarcomatous component. ( info) |
3/370. Diffuse metastatic infiltration of a carcinoma into skeletal muscle. Skeletal muscle is one of the most unusual sites of metastasis from any malignancy. We report a patient with rapidly progressive contractures due to metastatic infiltration of a carcinoma of unknown origin into the skeletal muscle. This 61-year-old man presented with a 1-month history of rapidly evolving, painful restriction of mobility of his right arm and his legs. Computed tomography showed diffuse metastatic nodules in all muscles, particularly in the hip abductors. Muscle biopsy revealed extensive infiltration of the muscle with carcinoma cells. ( info) |
4/370. Destruction of the glenoid joint fossa by a tenosynovial giant-cell tumour of the skull base: a case report. A 63-year-old man is presented in whom a tenosynovial giant-cell tumour had destroyed the temporomandibular joint fossa and expanded intracranially. The lesion was not diagnosed for a period of at least two years. Treatment included wide resection including the surrounding bone, dura and condyle. ( info) |
5/370. multiple myeloma metastatic to the thigh: successful treatment with radiation therapy. A 64-year-old man with metastatic multiple myeloma in the thigh was treated with radiation therapy. After a total dose of 30 Gy/10 fractions, significant resolution of the tumor in the thigh was observed. This case confirms the accepted dictum that multiple myeloma is a radioresponsive neoplastic disorder. ( info) |
| An asymptomatic, intrathoracic mass was found on imaging studies in a 53-year-old man. After excision it proved to be an extrapulmonary leiomyosarcoma, a rare malignancy of smooth muscle, originating from the right diaphragm. The location of this malignant tumor is rare in an adult. The tumor was resected, the diaphragm was reconstructed, and the patient should have a long-term cure and good quality of life. ( info) |
7/370. Sternocleidomastoid tumor of infancy: two cases of an interesting entity. Sternocleidomastoid tumor of infancy (SCMTI), also known as fibromatosis colli or muscular torticollis, is the most common cause of congenital torticollis. It is present in approximately 0.4% of live births, and usually 90% of patients will have a good prognosis if therapy is initiated and continued for the appropriate period of time. This paper presents two cases of SCMTI and explains the diagnostic modalities and treatment options for this entity. SCMTI should be diagnosed early in the infant's life, since early detection and initiation of conservative treatment leads to resolution of the disease in the majority of patients. ( info) |
8/370. chondrosarcoma in a patient with McCune-Albright syndrome. Report of a case. A case of McCune-Albright syndrome with acromegaly and chrondrosarcoma is reported. The potential role of chronic growth hormone overproduction in the occurrence of malignant transformation and the possible value of bisphosphonates in the treatment of bone fibrous dysplasias are discussed. ( info) |
9/370. Fibrous dysplasia with intramuscular myxoma (Mazabraud's syndrome). Report of a case and review of the literature. About 30 cases of fibrous dysplasia associated with one or more myxomas (Mazabraud's syndrome) have been reported since 1926. We report a new case in a woman with polyostotic fibrous dysplasia and a myxoma in the left femoral muscle. She also had a history of precocious sexual development and cafe au lait spots, two manifestations whose association with polyostotic fibrous dysplasia defines McCune-Albright syndrome. ( info) |
10/370. Diaphragmatic haemangioma. A case report. The case of a 4-year-old patient with a diaphragmatic haemangioma is reported. There were no symptoms and the only clinical finding was prominent subcutaneous vessels on the abdominal wall. The lesion was revealed by imaging and was excised. The findings and the differential diagnosis are discussed. ( info) |