1/4. XYY chromosome abnormality in sexual homicide perpetrators.In a retrospective investigation of the court reports about sexual homicide perpetrators chromosome analysis had been carried out in 13 of 166 (7.8%) men. Three men (1.8%) with XYY chromosome abnormality were found. This rate is much higher than that found in unselected samples of prisoners (0.7-0.9%) or in the general population (0.01%). The three men had shown prepubescent abnormalities, school problems, and had suffered from physical abuse. The chromosome analysis in all cases had been carried out in connection with the forensic psychiatric court report due to the sexual homicide. However, two men had earlier psychiatric referrals. All were diagnosed as sexual sadistic, showed a psychopathic syndrome or psychopathy according to the Psychopathy checklist-Revised [Hare RD, 1991, The Hare Psychopathy checklist-Revised, Toronto, ontario, canada: Multi-health Systems]. Two were multiple murderers. Especially forensic psychiatrists should be vigilant of the possibility of XYY chromosome abnormalities in sexual offenders.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
2/4. Gender dysphoria in a child with true hermaphroditism.This case report describes the psychosexual development of a child with true hermaphroditism who was assigned to the male sex at birth, but reassigned to the female sex at age two months. Given this child's excessive exposure to male sex hormone in utero, relative to physically normal females, one would predict a biological predisposition to behave in a masculine manner. This has occurred since two years of age. In addition, this child has had periodic episodes of gender disturbance, dysphoria, and ambivalence. In contrast, a physically normal fraternal twin sister has been conventionally feminine. A number of psychosocial factors appeared to have exacerbated the biologic predisposition to behave in a masculine manner, and thus may have been responsible for "pushing" this child into varying degrees of gender identity conflict. These included a closer father-daughter than mother-daughter relationship, parental tolerance of cross-gender behavior, and a mother who has been psychologically disturbed since the birth of her children. The heuristic value of this case will be discussed in relation to contemporary models of psychosexual development which emphasize the interaction of biological and psychosocial factors.- - - - - - - - - - ranking = 2keywords = physical (Clic here for more details about this article) |
3/4. Prolonged P-R interval in a male with 47,xyy karyotype.A 47,XYY male with an extremely prolonged P-R interval (0.42 sec) on the electrocardiograph is described. There was also a secondary R wave in lead V1. He had no past history of heart disease and no cardiac abnormality on physical examination.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
4/4. The development of four unselected 47,XYY boys.Four infants identified through neonatal screening programs are an unselected sample of 47,XYY boys. No consistent physical stigmata or medical disorders were identified. Three have increased height. All four demonstrated problems in motor and language development. Although their intelligence is within the average range, all four have language-related learning disorders requiring special education. Mild depression was apparent in all four, perhaps as a secondary result of their learning disorders. Some of the problems seen in the propositi are found in milder forms in other family members, leading to the hypothesis that their karyotype may heighten vulnerability to pre-existing familial conditions. Similarities between these findings and results from seven other study centers with a total of 42 47,XYY boys are noted. parents of a prenatally diagnosed 47,XYY fetus seen in our center are informed that the extra y chromosome represents a risk factor for these problems, but that environment remains a primary force in shaping their child's development.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |