1/2. Pseudohypertestosteronemia during danazol therapy. A case report.Several steroid radioimmunoassay kits, particularly testosterone, cross-react with danazol, producing false elevations of serum steroid levels. A patient taking danazol simultaneously developed signs of virilization and an apparent 15-fold elevation in her serum testosterone. Discontinuation of danazol resulted in a prompt return to physical and biochemical normality.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
2/2. A virilizing hilus-cell tumour in an African patient with Turner's syndrome.A 26-year-old African female presented with primary amenorrhoea and genital abnormalities. She had the physical stigmata of Turner's syndrome and a 45, X karyotype. Severe masculinization of the external genitalia, apparently present from birth, was present and a laparotomy revealed a hilus-cell tumour of the right streak gonad. Clitoridectomy and vaginoplasty were performed but subsequent oestrogen therapy failed to produce breast development.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |