1/16. Neonatal urticaria due to prostaglandin E1.Prostaglandin E1 is commonly used in the management of cyanotic congenital heart disease. While cutaneous flushing and peripheral edema are well recognized side effects of prostaglandin E1 therapy, other cutaneous effects have not been described in the dermatologic literature. We report a neonate with transposition of the great vessels who developed urticaria during treatment with prostaglandin E1.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
2/16. purpura with cold urticaria in a patient with hepatitis c virus infection-associated mixed cryoglobulinemia type III: successful treatment with interferon-beta.We describe a 54-year-old man with hepatitis c virus (HCV) infection-associated cryoglobulinemia type III. The patient had suffered from cold-induced urticaria that left purpuric eruptions up to 1 cm in diameter, intermittent migratory joint pain for seven years and mild liver dysfunction for nine years. hemophilia a was diagnosed when the patient was 26 years old, and he was then given infusions of factor viii for a short time. In both skin biopsy samples from urticarial and purpuric eruptions, mild inflammatory infiltration by polymorphonuclear leukocytes with nuclear dust, extravasation of erythrocytes and deposition of IgM and C3 in the superficial blood vessels were observed. After antiviral treatment with interferon-beta, the clinical symptoms and the cryoglobulin and HCV-rna in the serum disappeared. There has been no recurrence in the subsequent nine years.- - - - - - - - - - ranking = 23.094253598411keywords = blood vessel, vessel (Clic here for more details about this article) |
3/16. Hypocomplementemic urticarial vasculitis: a rare presentation of systemic lupus erythematosus.BACKGROUND: Urticarial vasculitis is a small-vessel vasculitis, presenting clinically as persistent urticarial skin lesions and microscopically as leucocytoclastic vasculitis. Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a distinct type of urticarial vasculitis with multiorgan involvement, whose etiology and link with other diseases are still unknown. Some authors have suggested that HUVS can be accompanied by systemic lupus erythematosus (SLE), and others believe that it is a rare subtype of SLE. Urticarial vasculitis is seen in 7-8% of SLE, while 50% of HUVS patients are diagnosed with SLE. OBSERVATIONS AND RESULTS: We report a case of HUVS associated with SLE with fatal outcome unresponsive to the combination of systemic corticosteroids and azathioprine. CONCLUSIONS: SLE and HUVS share both clinical and laboratory features and are probably not separate entities. It is mostly likely that HUVS and SLE fall into the same spectrum of autoimmune diseases. HUVS is probably a subset of SLE. As both diseases can fatally, it should be kept in mind that the overlap of SLE and HUVS may exhibit a relatively rapid progression and poor prognosis.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
4/16. Urticarial vasculitis associated with a monoclonal IgM gammopathy: Schnitzler's syndrome.We describe two cases of Schnitzler's syndrome presenting with urticarial vasculitis, in which there was a monoclonal IgM of kappa light-chain isotype. skin histology showed a perivascular leucocytic infiltrate and leucocytoclasis. One patient had an abnormal complement profile and positive rheumatoid factor while the other had antibodies to unidentified soluble nuclear antigens, anti-cytoplasmic antibodies and circulating immune complexes. In addition, in the first case deposits of IgM, C3 and, to a lesser degree, of IgG were observed in the walls of small blood vessels.- - - - - - - - - - ranking = 23.094253598411keywords = blood vessel, vessel (Clic here for more details about this article) |
5/16. Jaccoud's arthritis and panvasculitis in the hypocomplementemic urticarial vasculitis syndrome.We describe a woman who developed hypocomplementemic urticarial vasculitis syndrome, and who demonstrated 2 rare features. As well as vasculitis of the small cutaneous vessels, vasculitis affected the femoral, cystic and renal arteries. Her arthritis led to subluxation of the metacarpophalangeal joints, without radiological evidence of rheumatoid-like erosions. This deformity could be passively corrected, and therefore conformed to the pattern described by Jaccoud.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
6/16. urticaria associated with acute viral hepatitis type B: studies of pathogenesis.To determine whether skin deposition of circulating immune complexes contributes to prodromal urticaria of acute hepatitis B, we studied two patients with hepatitis B who presented with urticaria and fever. During the urticarial prodrome but not thereafter, we found activation of both classic and alternative complement pathways. Hepatitis B surface antigen (HBsAg)-antibody complexes were identified (by electron microscopy) in cryoprecipitates from both patients and IgG (by immunodiffusion) in cryoprecipitates of one patient during urticaria. light and electron microscopy of involved urticarial skin revealed necrotizing venulitis in both patients. Immunofluorescence microscopy showed fibrin within involved cutaneous vessel walls in one patient and C3, IgM, and HBsAg, which were not detected in simultaneously obtained uninvolved skin, in both patients. Our findings suggest that deposition of circulating immune complexes containing HBsAg is important in the pathogenesis of urticaria associated with acute hepatitis b virus infection.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
7/16. Hypocomplementemic urticarial vasculitis syndrome responsive to dapsone.A 45-year-old woman with cutaneous urticaria-like lesions subsequently developed polyarthritis, glomerulonephritis, and chronic obstructive pulmonary disease. biopsy of skin showed leukocytoclastic vasculitis of superficial capillaries. biopsy of the kidney revealed mesangioproliferative glomerulonephritis, and lung biopsy revealed severe emphysema and thick-walled blood vessels with immunoglobulin deposition. Therapy with dapsone produced dramatic improvement of the patient's cutaneous vasculitis and arthritis. This case uniquely demonstrates the efficacy of dapsone for both the urticarial vasculitic and the arthritic components of this syndrome and reemphasizes the potentially severe pulmonary and renal complications.- - - - - - - - - - ranking = 23.094253598411keywords = blood vessel, vessel (Clic here for more details about this article) |
8/16. Localized heat urticaria associated with a decrease in serum complement factor b (C3 proactivator).A case of localized heat urticaria is reported in a 51-year-old woman who within a few minutes of contact with warm water developed erythema and swelling sharply localized to the heated area. After a hot bath urticarial lesions appeared over large areas of her body, accompanied by a feeling of weakness, but no other systemic symptoms. After challenge with heat by immersing her left arm in water heated to 42 degrees C, a rapid decrease of her serum complement level of factor B was demonstrated, suggesting that activation of an alternative complement pathway plays a role in this form of urticaria. Biopsies for immunofluorescent study of complement and immunoglobulins were negative at 30 and 180 min after heat challenge. The dermal fibres and endothelial cells of dermal vessels were capable, in vitro, of complement binding before and after exposure to heat.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
9/16. Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone.We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p less than 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p less than 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.- - - - - - - - - - ranking = 23.094253598411keywords = blood vessel, vessel (Clic here for more details about this article) |
10/16. Pathogenesis of papular urticaria.The presence of immunoglobulin and complement deposits in the skin of three patients with papular urticaria suggests that these lesions may be due to a cutaneous vasculitis. These deposits were most frequently found in biopsy specimens taken from lesions within 24 hours of their development. The presence of granular deposits of Clq, C3, and IgM in the walls of the superficial dermal blood vessels suggests that immune complexes (IgM aggregates) may be primarily involved in the pathogenesis of these lesions, with complement activation initiated by Clq through the classical pathway.- - - - - - - - - - ranking = 23.094253598411keywords = blood vessel, vessel (Clic here for more details about this article) |
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