1/3. Immunohistochemical tenascin-C expression in paediatric supratentorial glioblastoma multiforme.tenascin-C (TN-C) plays an important part in the growth of neoplastic tissue, leading to new vessel development. TN-C has been assessed in adult glioblastoma multiforme (GBM) and has been evaluated as anti-neoplastic therapy. No studies have focused on this tissue in paediatric GBM. tissues were obtained from six paediatric supratentorial GBMs. immunohistochemistry was performed using a mouse antibody directed against human TN-C, and expression in tumour vasculature was described on the basis of TN-C immunoreactivity. The expression was minimal in three, moderate in two, and intense in one specimen. TN-C was not correlated with clinical history, neurological findings, or with tumour site. Although based on a limited number of patients, this study provides additional insights into tumour growth modulation and cytogenetic profile of paediatric GBM. The detailed understanding of events responsible for GBM growth is a prerequisite for the development of therapeutic modalities leading to improved prognosis and cure.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
2/3. MR appearance of the persistent hypoglossal artery.We describe the MR appearance of the persistent hypoglossal artery incidentally found in a case of known glioblastoma multiforme. On the spin-echo images, an abnormal tubular structure of low intensity penetrating the hypoglossal canal was recognized. MR angiography showed its vascular nature and the anomalous vessel connecting the internal carotid and basilar arteries.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
3/3. gadolinium-enhanced magnetic resonance angiography in the planning of supratentorial glioma surgery.The utility of gadolinium (Gd)-enhanced magnetic resonance (MR) angiography in the planning of supratentorial glioma surgery was evaluated. MR angiograms of the arterial and venous anatomy visualized the anatomical relationship of the main arteries to the tumor, especially on three-dimensional images. Combination with data from surface anatomical images allowed the tumor location to be determined preoperatively. Gd-enhanced MR angiography can be used non-invasively prior to tumor surgery to ascertain the spatial relationship of the vessels to the tumor mass.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |