1/4. Immune complex vasculitis, polymyositis, and hyperglobulinemic purpura.This is the first description of a patient with both polymyositis and Waldenstrom hyperglobulinemic purpura. There was evidence of circulating immune complexes, and immune deposits were found in dermal and muscular vessels. Similar electron-dense deposits were seen ultrastructurally in the basement membrane of both normal and abnormal microvasculature. The findings suggest that the muscle and skin lesions may be associated with deposition of circulating immune complexes in and around blood vessels, followed by complement activation and subsequent inflammation.- - - - - - - - - - ranking = 1keywords = blood vessel, vessel (Clic here for more details about this article) |
2/4. Hypergammaglobulinemic purpura in patients with sjogren's syndrome: a report of nine cases and a review of the Japanese literature.Nine patients with hypergammaglobulinemic purpura associated with primary sjogren's syndrome were presented. All patients were female (mean age 45.6) and showed recurrent purpura on the lower extremities and typical findings of sjogren's syndrome with high gammaglobulin and IgG levels, rheumatoid factors, anti-SSA/SSB antibodies (5/5) and anti-nuclear antibodies (6/9). vasculitis was seen in 6 patients, 4 were of the mononuclear cell type and 2 of the neutrophilic cell type. Six patients had intermediate complexes between 7S and 19S shown by serum ultracentrifugation. Immunofluorescent staining showed immunoglobulin deposition along the blood vessel walls of the skin in these patients. These data suggest that hypergammaglobulinemic purpura in sjogren's syndrome is vasculitis caused by immunologic processes.- - - - - - - - - - ranking = 0.99013295577597keywords = blood vessel, vessel (Clic here for more details about this article) |
3/4. Immune complexes in the pathogenesis of hypergammaglobulinemic purpura.Direct immunofluorescence (DIF) was performed and circulating immune complex (CIC) levels evaluated in three patients with hypergammaglobulinemia purpura (HGP) of Waldenstrom. The Raji cell immunoradiometric assay was used to detect complexes of both IgG and IgM type. IgM and C3 were detected in blood vessel walls of all three patients. Elevated levels of IgG complexes were detected in two patients, and elevated levels of IgM complexes were detected in all three patients. Clinical improvement after plasmapheresis was noted in one patient. A cause-and-effect relationship between CIC and the inflammation of the superficial dermal blood vessels is postulated.- - - - - - - - - - ranking = 1.9802659115519keywords = blood vessel, vessel (Clic here for more details about this article) |
4/4. Hyperglobulinemic purpura in the course of multiple myeloma.Secondary hyperglobulinemic purpura of Waldenstrom is characterized by polyclonal gammopathy associated mainly with autoimmune diseases. Its occurrence with multiple myeloma is very rare. We described a patient who developed characteristic lesions of hyperglobulinemic purpura in the course of IgA myeloma. skin biopsy revealed deposition of IgA in the blood vessels.- - - - - - - - - - ranking = 0.99013295577597keywords = blood vessel, vessel (Clic here for more details about this article) |