1/5. Inflammatory stage of disseminated superficial porokeratosis.Disseminated superficial porokeratosis (DSP) is a keratinization disorder characterized by multiple small lesions with a slightly elevated, sharply defined ridge over the whole body. Unusual DSP cases with acute exacerbation of their lesions accompanied by severe pruritus have been reported and designated as "eruptive pruritic papular porokeratosis" or "inflammatory DSP". Histologically, the pruritic lesions in the majority of these unusual DSP cases had a dense infiltration of eosinophils and lymphocytes in the vicinity of blood vessels in the upper dermis. In this report, we describe an additional case of DSP with a similar clinical course and histopathological findings. A review of the literature showed that the pruritic condition in these unusual DSP cases can be transient and is not necessarily related to spontaneous regression. We propose the term "Inflammatory stage of DSP" for describing this unusual variant of DSP.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
2/5. Resolution of inferior vena cava syndrome after embolization of a hepatic adenoma.A 77-year-old man presented with severe pruritus and massive lower body edema. Computerized axial tomography of the abdomen showed a large hepatic mass compressing the inferior vena cava, and a liver biopsy specimen showed hepatic adenoma. Embolization of vessels feeding the hepatic tumor resulted in complete resolution of pruritus and ascites, and clinical remission has persisted for 1 year following partial obliteration of tumor vasculature. Angiographic ablation of tumor blood supply represents a nonoperative means for inducing clinical remission in patients with symptomatic hepatic adenoma who are at high surgical risk.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
3/5. Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone.We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr. In a double-blind, placebo-controlled study, cimetidine alone was at least as effective as chlorpheniramine in relief of urticaria and angioedema. Additionally, cimetidine significantly inhibited (p less than 0.01) the wheal response to histamine when it was compared to placebo. The inhibition of wheal response to histamine by cimetidine was significantly higher (p less than 0.05) than chlorpheniramine. The presence of predominantly H2- rather than H1-histamine receptors in the cutaneous blood vessels may be responsible for the therapeutic effects of cimetidine in this patient.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
4/5. Pruritic urticarial papules and plaques of pregnancy.Pruritic urticarial papules and plaques of pregnancy is a self-limiting disease generally seen in the first pregnancy during the third trimester. Lesions are frequently present centrally and are intensely pruritic. Mucous membranes are usually not involved. histology shows a normal epidermis with mild perivascular lymphohistiocytic infiltrate. blood vessels, cutaneous appendages, and subcutaneous tissue are normal. Immunofluorescence studies are negative. A review of the reported cases suggests that there is no increased incidence of fetal mortality or congenital malformations and that recurrences do not occur in most cases. Etiology is unknown. Treatment should be directed toward symptomatic relief only.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
5/5. Enlarging congenital haemangioma in an adult--a new entity?We report the case of a 39-year-old woman with a persistent congenital vascular lesion, which unusually is continuing to enlarge. Histologically, the lesion is a thin-walled haemangioma with numerous mast cells. Currently, the precise mechanism of vessel proliferation in such lesions is unknown, but it is important in the pathogenesis of both haemangiomas and other dermatological conditions, as well as in wound healing and the formation of tumour metastases. We discuss various angiogenic factors with particular reference to the putative role of the mast cell in the pathogenesis of haemangiomas.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |