1/2. splenic rupture as a complication of P. falciparum malaria after residence in the tropics. Report of two cases.splenic rupture is an uncommon complication of malaria, which requires urgent medical investigation, close follow-up and adequate treatment. Until present, this complication was reported more often in P. vivax infections than in infections with other species. Rupture can happen spontaneously or as a result of trauma, which may be minor and unnoticed. The diagnosis is made by physical examination, ultrasound and CT-scan. Especially in malaria endemic areas the management of splenic rupture in malaria should be focused on splenic preservation. We describe two cases of splenic rupture during a P. falciparum infection, both requiring finally splenectomy.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
2/2. quinine-resistant severe falciparum malaria effectively treated with atovaquone and proguanil hydrochloride combination therapy.A 22-year-old Japanese man noticed pyrexia and diarrhea after travel to guinea. Notable physical findings included hepatosplenomegaly. Treatment with oral quinine and minocycline was started after definitive diagnosis of falciparum malaria by blood smear. Initially, parasitemia and body temperature decreased but by the third night of therapy his temperature increased to 40 degrees C with a slight increase of parasite count. When quinine treatment was changed to atovaquone/proguanil, his temperature dropped immediately and complete plasmodial elimination was confirmed on microscopic examination. Subsequent recrudescence of the disease was not observed. It was concluded that the antimalarial treatment with atovaquone/proguanil might become invaluable in japan.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |