1/72. The histopathology of cutaneous lesions of Kikuchi's disease (necrotizing lymphadenitis): a report of five cases.Kikuchi's disease (KD) is an idiopathic, self-limited necrotizing lymphadenitis that can clinically and histologically mimic high-grade lymphoma, including Hodgkin's disease, or can be mistaken for the lymphadenitis of systemic lupus erythematosus (SLE). Involvement of extranodal sites is unusual but well documented, especially in asia, where KD is more common than in north america or europe. The successful distinction of KD from malignant lymphoma and SLE is imperative for the appropriate treatment of affected patients. We describe five patients with cutaneous involvement by KD, all of whom presented with fever, lymphadenopathy, and an eruption on the skin of the upper body, which in one case was clinically suspected to be due to SLE and in another, polymorphous light eruption. The patients ranged in age from 10 months to 42 years (median, 33 years) and included three females and two males. All five patients had negative serologic studies for collagen vascular disease. Each patient had a lymph node biopsy showing the typical necrotizing lymphadenitis of KD. skin biopsies from all five patients shared a specific constellation of histologic features: vacuolar interface change with necrotic keratinocytes, a dense lymphohistiocytic superficial and deep perivascular and interstitial infiltrate, varying amounts of papillary dermal edema, and abundant karyorrhectic debris with a conspicuous absence of neutrophils and a paucity of plasma cells, paralleling the nodal histology in KD. CD68 immunohistochemistry on paraffin-embedded sections showed many histiocytes and plasmacytoid monocytes in all cases, whereas CD3, CD4, and CD8 showed highly variable staining among the cases. There was only rare staining with TIA-1 and CD30. We believe that the papular eruption of KD has recognizable histopathologic features and that a CD68 stain that marks many cells that initially seem to be lymphocytes can be performed to confirm the diagnosis.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
2/72. Inguinal lymphadenitis caused by entamoeba histolytica: case report and literature review.liver abscesses are the most common manifestation of extraintestinal infection by entamoeba histolytica. Involvement of other sites, including the peritoneum, pericardium, brain, or genitourinary tract, is unusual. We describe a case of inguinal necrotizing lymphadenitis caused by E histolytica. Our patient responded well to surgical drainage, metronidazole, and paramomycin therapy. A literature review of genitourinary and other uncommon sites of E histolytica infection is included.- - - - - - - - - - ranking = 0.16666666666667keywords = necrotizing (Clic here for more details about this article) |
3/72. herpes simplex virus lymphadenitis: case report and review of the literature.Localized or regional necrotizing lymphadenitis is an extremely uncommon manifestation of herpes simplex virus (HSV) infection. We report a case of necrotizing HSV lymphadenitis in a patient with both common variable immunodeficiency and natural killer cell deficiency and review the literature on this unusual complication of HSV infection.- - - - - - - - - - ranking = 0.33333333333333keywords = necrotizing (Clic here for more details about this article) |
4/72. mycobacterium bohemicum cervical lymphadenitis.A lymph node excision was performed on a 2-year-old child with right submandibular swelling not responding to oral cefaclor therapy. histology revealed granulomatous, partly necrotizing lymphadenitis and a large number of acid-fast bacilli subsequently identified by molecular techniques as mycobacterium bohemicum.- - - - - - - - - - ranking = 0.16666666666667keywords = necrotizing (Clic here for more details about this article) |
5/72. Is human herpesvirus 6 linked to kikuchi-fujimoto disease? The importance of consistent molecular and serologic analysis.BACKGROUND: Kikuchi-Fujimoto disease, also called histiocytic necrotizing lymphadenitis, is a self-limiting lymphadenopathy of unknown cause. The patient often presents with fever, malaise, and lymphadenopathy primarily involving the cervical lymph nodes. Laboratory findings are nonspecific, and the diagnosis is established by identifying characteristic pathologic features from lymph node biopsy. The etiologic agent has been proposed to be of viral origin; specifically, human herpesvirus 6 (HHV-6) has been implicated. methods: The clinical, histologic, serologic, and molecular data from 471 cases of Kikuchi-Fujimoto disease reported between 1982 and 2001 and their relationship to HHV-6 were reviewed. RESULTS: Thirty-two of the 471 patients in this review were tested for HHV-6 serology; all 32 had elevated titers for HHV-6. One hundred twelve patients with lymphadenopathies, including histiocytic necrotizing lymphadenitis, tested positive for HHV-6 by polymerase chain reaction. in situ hybridization results were positive in 41 cases. CONCLUSION: This review illustrates the necessity for consistent molecular and serologic analysis.- - - - - - - - - - ranking = 0.33333333333333keywords = necrotizing (Clic here for more details about this article) |
6/72. Lupus lymphadenitis simulating Kikuchi's lymphadenitis in patients with systemic lupus erythematosus: a clinicopathological analysis of six cases and review of the literature.Kikuchi's disease (KD) or Kikuchi's lymphadenitis (KL) is a self-limiting disease mostly affecting the cervical lymph nodes of young individuals. Whether the reported cases of KL associated with systemic lupus erythematosus (SLE) were genuine KL or lupus lymphadenitis (LL) simulating KL in SLE patients is not clear. We analyzed six cases of KD-like lymphadenitis occurring in SLE patients and 12 reported cases to clarify the relationship between KL and SLE. We found that not all cases occurred simultaneously with SLE. Eight cases occurred either before or after SLE. These cases might have true KL independent of SLE with the exception of two cases that occurred after SLE, but the patients still had lupus activity. The 10 cases that coexisted with SLE most likely had LL rather than KL. This was supported by the immunohistochemical finding of sparse cytotoxic T cells in those lymph nodes in contrast to abundant cytotoxic T cells usually seen in a typical KL. We conclude that KL is not related to SLE, and KD-like lymphadenitis coexisting with SLE should be regarded as LL. Pathologists should be aware of the possibility that LL can mimic KL in patients with SLE, especially necrotizing-type KL.- - - - - - - - - - ranking = 0.16666666666667keywords = necrotizing (Clic here for more details about this article) |
7/72. Necrotizing lymphadenitis: possible acute toxoplasmic infection.A rapid rise in serum hemagglutination antibody (HA) titers for toxoplasma was detected about 2 months after the onset of cervical lymphadenopathy in two patients with necrotizing lymphadenitis. These lymph nodes proliferation of histiocytes with nuclear debris, phagocytized macrophages and necrotic areas, and the association suggested that necrotizing lymphadenitis might be caused by acute toxoplasmic infection.- - - - - - - - - - ranking = 0.33333333333333keywords = necrotizing (Clic here for more details about this article) |
8/72. Kikuchi's lymphadenitis: report of a yersinia enterocolitica-associated case and an overview of aetiology and clinical outcome.Kikuchi's lymphadenitis (KL; histiocytic necrotizing lymphadenitis without granulocytic infiltration) is a generally benign, febrile disorder of unknown aetiology with distinct histological features. To date, a minority of cases reported have been associated with infectious agents. A typical pathological case of KL is described where involvement of yersinia enterocolitica was shown by an indirect immunofluorescent assay applied to lymphatic tissue. The case is discussed with emphasis on recent insight into the course and aetiology of KL.- - - - - - - - - - ranking = 0.16666666666667keywords = necrotizing (Clic here for more details about this article) |
9/72. Sweet's syndrome associated with subacute necrotizing lymphadenitis.A 34-year-old man with Sweet's syndrome associated with subacute necrotizing lymphadenitis is reported. Histological examination of an erythematous, painful, cutaneous plaque revealed a dermal interstitial neutrophilic infiltrate. A biopsy specimen obtained from an inguinal lymph node showed granulomatous formation, consisting of histiocytes, with central necrosis in the paracortex and macrophages in the sinus. Although the causes of the two diseases remain obscure, this appears to be the first report of Sweet's syndrome associated with subacute necrotizing lymphadenitis.- - - - - - - - - - ranking = 11.969038433614keywords = subacute necrotizing, necrotizing (Clic here for more details about this article) |
10/72. Fine needle aspiration cytology in lupus lymphadenopathy. A case report.This case report describes the aspiration cytologic characteristics of histologically proven acute lupus lymphadenitis. The aspirate contained numerous lymphoid cells and many amorphous, basophilic, hematoxylin-stained bodies dispersed in a granular, necrotic background that lacked polymorphonuclear leukocytes. The lymphadenopathy was diagnosed cytologically as necrotizing lymphadenitis and histologically as acute lupus lymphadenitis.- - - - - - - - - - ranking = 0.16666666666667keywords = necrotizing (Clic here for more details about this article) |
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