1/39. Palisaded, encapsulated neuroma of the lip.A case of palisaded, encapsulated neuroma of the lower lip has been presented. To the best of our knowledge, this is the first reported instance in the dental literature. The lesion characteristically occurs on the skin of the face near the oral, nasal, and orbital mucocutaneous junctions and, therefore, is readily visible to the oral diagnostician. It occurs most often in middle-aged individuals and, although it may clinically mimic other lesions, the operative finding of an easily enucleated mass near a mucocutaneous junction should suggest this lesion in the differential diagnosis. Histologically, the lesion is characterized by three distinct zones--an outer compressed fibrous connective tissue capsule, an inner myxomatous zone, and a central zone of proliferating Schwann's cells arranged in interlacing fascicles with areas of palisaded cells and organoid structures. The lesion is treated by enucleation or excision and has no tendency to recur.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
2/39. From eyelid bumps to thyroid lumps: report of a MEN type IIb family and review of the literature.PURPOSE: We present a two-generation family with multiple endocrine neoplasia (MEN) type IIb diagnosed by their ophthalmologists based on characteristic ophthalmic findings. methods: A family consisting of a 33-year-old female proband and her 8- and 7-year-old children had prominent corneal nerves; eyelid, lip, and tongue nodules; and a characteristic facies. A polymerase chain reaction-based genetic assay was obtained to detect the genetic mutation most commonly associated with MEN type IIb. serum calcitonin and urine catecholamine studies were obtained. RESULTS: Molecular genetic studies detected in all 3 patients a mutation at codon 918 of the RET proto-oncogene known to be present in 95% of the cases of MEN type IIb. serum calcitonin was elevated in the proband and her son. urine catecholamine levels were elevated in the proband. Surgical treatment and histologic analysis confirmed pheochromocytoma and medullary thyroid carcinoma (MTC) in the proband. Surgical exploration revealed the MTC to be metastatic to the liver. CONCLUSIONS: This family demonstrates the characteristic findings of MEN type IIb: prominent corneal nerves in a clear stroma and multiple submucosal neuromas of the conjunctiva, eyelids, lips, and tongue. Ophthalmologists have a critical role to play in recognizing these signs, because the early diagnosis of medullary thyroid carcinoma and pheochromocytoma may be life saving.- - - - - - - - - - ranking = 42.994724862934keywords = nerve (Clic here for more details about this article) |
3/39. Trichoblastic carcinoma: a report of two cases of a deeply infiltrative trichoblastic neoplasm.BACKGROUND: Trichoblastoma is a benign neoplasm with primitive hair follicle differentiation. The tumor is characterized by nests and cords of epithelial cells in an organized relationship with stroma. Some of the epithelial cells resemble follicular germ and other cells show follicular sheath differentiation. The neoplasm is symmetrical and well circumscribed. In addition, cytologic examination shows no atypia. Concept of its malignant counterpart is poorly understood. OBJECTIVE: We report two trichoblastic neoplasms that show histologic features of malignancy. methods: skin biopsies from the lip region of a 53-year-old female and a 74-year-old male who had presented with the neoplasms in that location for several years were reviewed. Excised specimens measured 2 x 1 x 1 cm and 1.6 x 0.7 x 0.8 cm respectively. RESULTS: The histologic sections revealed locally aggressive neoplasms showing prominent differentiation towards hair germ and follicular sheath with formation of papillary mesenchymal bodies, follicular bulb-like structures, small keratin cysts and rare malformed hair shaft. The neoplasm showed asymmetry of architecture and massive subcutaneous and muscular infiltration. CONCLUSION: With demonstration of these two cases and references of few other reported cases we raise the possibility of existence of trichoblastic carcinoma that is distinct from basal cell carcinoma.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
4/39. Metachronous multiple carcinoma of lip after surgery for gingival carcinoma: a case report.A case of multiple carcinoma of the lower lip probably induced by repeated bite trauma due to lack of sensation is reported. A reduction in immunocompetence by carboplatin (CBDCA) might be an additional condition for the carcinogenesis. This case suggests that the reconstruction of the sensory nerve is important after resection of a malignant tumor of the head and neck region.- - - - - - - - - - ranking = 21.497362431467keywords = nerve (Clic here for more details about this article) |
5/39. The therapy of virus-associated epithelial tumors of the face and the lips in organ transplant recipients.The risk of developing malignant cutaneous neoplasms is increased after organ transplantation. We report three patients with malignant tumors of the epithelium of the facial skin and the lips after kidney and heart transplantation, respectively. They showed an aggressive course of the disease with more than five synchronous or metachronous basal cell and squamous cell carcinomas. Tissue samples were Epstein-Barr virus (EBV) positive by PCR. Using an in situ hybridization technique EBV-encoded rna (EBER) was detected in tumor-infiltrating lymphocytes. The aggressive course was not alone controllable by surgical or radiological therapy. The systemic and topical application of cidofovir (Vistide) led to remarkable remissions, to a better confinement and operability of the tumors, and to a cessation of tumor pain. The photodynamic therapy represents another opportunity for managing superficial local recurrences and multiple tumors. In conclusion, the results of these case reports demonstrate that combined antiviral, photodynamic and surgical therapy may be used successfully to treat aggressive cutaneous malignancies in patients after organ transplantation.- - - - - - - - - - ranking = 6keywords = organ (Clic here for more details about this article) |
6/39. The use of sentinel node biopsy in the management of epitheloid haemangioendothelioma of the lip.This report describes a rare tumour, an epitheloid haemangioendothelioma affecting the lower lip. This tumour has a predilection for the head and neck region in young adults. Its potential to metastasise is well recognised, but the likelihood of this is currently uncertain. Current management is usually to locally excise the tumour and follow up, although there is a recognised risk that subsequent presentation with metastatic nodal disease can occur. We present a case occurring in the lip of an 18-year-old girl who had a sentinel node biopsy performed as a staging tool in conjunction with excision of a local recurrence. Although clinical examination and CT imaging of the head and neck found no evidence of metastatic disease, the sentinel node was found to contain metastatic tumour. The result of this unexpected finding was that she was investigated further with additional CT scanning of her chest and abdomen. Subsequently, a therapeutic modified radical neck dissection preserving the accessory cranial nerve was undertaken. After 3 years she remains well with no evidence of recurrent tumour. We believe that the consequence of undergoing sentinel node biopsy, which detected early metastatic tumour and her subsequent treatment, suggests a role for sentinel node biopsy in the management of epitheloid haemangioendothelioma.- - - - - - - - - - ranking = 21.497362431467keywords = nerve (Clic here for more details about this article) |
7/39. Traumatic neuroma in the lower lip arising following laser/cryosurgery to treat a mucocele.A 15-year-old girl presented with a painless recurrent swelling on her right lower lip mucosa for about 10 months. She had a past history of treatment with laser surgery and cryosurgery. The clinical diagnosis was a 'recurrent mucocele'. Histopathological examination of the surgical specimen revealed a mucocele close to a neuroma with irregular nerve fascicles, leading to a diagnosis 'mucocele accompanied with a traumatic neuroma'. In the present report, the traumatic neuroma appears to have arisen following laser or cryosurgery.- - - - - - - - - - ranking = 21.497362431467keywords = nerve (Clic here for more details about this article) |
8/39. Schwannoma of the upper lip: case report and literature review.Schwannomas, arising from nerve-sheath schwann cells, rarely occur in the lip area. A medline search in English literature from 1966 to 2002 revealed only 6 documented cases of schwannomas of the lip. We report the unusual case of a 22-year-old female patient who developed a schwannoma of the upper lip. Histopathological examination and immunohistochemical staining studies were performed, with the relevant literature for this clinical rarity also reviewed. Complete enucleation of the schwannoma usually achieves cure. Although very rare, schwannoma should be taken into consideration in the differential diagnosis of any upper lip mass.- - - - - - - - - - ranking = 21.497362431467keywords = nerve (Clic here for more details about this article) |
9/39. Neurotropic melanoma. A case report and review of the literature.Neurotropic melanoma is a rare tumor with a biphasic growth pattern associated with a change in morphology from melanocytic features toward Schwann cell features. The tumor thereby develops a capacity for infiltrating nerves which may result in clinically evident cranial neuropathies, most commonly of the fifth and seventh cranial nerves. The histology of this lesion is difficult to interpret; it often erroneously appears fibrous in origin and may be considered to be benign. Despite this benign appearance histologically, the tumor behaves aggressively with multiple local recurrences and possible CNS invasion by either direct perineural growth or distant metastases. We review the literature of neurotropic melanomas and report a 46th case which describes a typical course with neural invasion. Although a rare cause of cranial neuropathies, the neurologist should consider this entity in the differential diagnosis and the history of a recurrent skin lesion of the face should be sought whenever examining such a patient.- - - - - - - - - - ranking = 42.994724862934keywords = nerve (Clic here for more details about this article) |
10/39. Combined tongue flap and V-Y advancement flap for lower lip defects.A combined tongue flap and V-Y advanced flap were used for reconstruction of the lower lip after radical excision of squamous cell carcinoma. This V-Y advancement flap is useful because the procedure does not require any difficult technique, and preservation of the orbicularis oris muscle and the branch of the mental artery and nerve are possible. The vermilion is reconstructed with a tongue flap, with almost no disturbance in the patients' speaking or eating and satisfactory cosmetic results. We describe this procedure in two cases.- - - - - - - - - - ranking = 21.497362431467keywords = nerve (Clic here for more details about this article) |
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