1/7. Sinus polyp-associated soft tissue lesion and unilateral blindness: complications of extraction in leukemic patient.A case of an inflammatory polyp-associated lesion extending through an extraction socket appearing as an intraoral nodular lesion and unilateral blindness secondary to leukemic optic nerve head infiltration is reported. The patient was a 28-year-old male whose his upper first molar had been extracted fifteen days previously. The lesion was an asymptomatic soft tissue mass, red in color and hot tender to palpation, involving the alveolar ridge in the maxillary molar area. Although this is apparently a rare occurrence, the nature of the lesion was suggested by the history, clinical appearance, and radiographic findings. Excision of the inflammatory lesion was followed by complete healing with closure of the lesion. Unfortunately, the blindness was irreversible. The patient is still under leukemia therapy. review of the literature did not yield any other such cases. The role of oral lesions as a diagnostic indicator and the importance of dental surgeons in the diagnosis of leukemic patients are discussed. It is concluded that proper precautions and meticulous early diagnosis are required in these patients and that dental practitioners should be aware of the diagnostic features and possibilities of oral complications associated with leukemia.- - - - - - - - - - ranking = 1keywords = nerve (Clic here for more details about this article) |
2/7. The diagnosis from the pathological viewpoint of a blood disease.The histopathological viewpoints of a blood diseases are namely following the cytological examinations except for the viewpoint of organ pathology and has been required only the usefulness in case with the difficulty of cytological examination. If it looks at a blood disease as hematopoietic organ disease, histopathological diagnostic study might make the new paradigm of blood diseases. In this time, I would like to present the hematological diagnosis from the pathological viewpoint by using histological bone marrow sections. *How to examine the bone marrow histology *Hematopoietic microenvironment disorder *Differential diagnosis of hypoplastic marrow lesions *Clinicopathological characteristics of Hypoplastic leukemia *Hemophagocytosis in bone marrow *How to diagnose MDS by histopathology. bone marrow histology is the valuable diagnostic tool of many kinds of marrow disorders especial cases. By using immunohistochemistry and Giemsa staining, further information might obtain than smear film cytology. bone marrow clot section aspirated from sternum is enough for histological examination except bone marrow biopsy. Precise cytomorphology might demonstrate by smear film than section histology. However surface phenotype would define by flow cytometric analysis, immunostaining of sections could demonstrate which cells show which markers. Structural and architectural disorder could only be represent by histology. The histological examination of bone marrow might introduce a new aspects of blood disease.- - - - - - - - - - ranking = 9.1972839506173keywords = organ (Clic here for more details about this article) |
3/7. coccidioidomycosis in hematopoietic stem cell transplant recipients.coccidioidomycosis is an endemic fungal infection of the desert southwestern united states that can cause devastating disseminated infection in immunocompromised persons. Clinical coccidioidomycosis, which is caused by coccidioides species, has been well characterized in patients who have had solid organ transplants, but it has rarely been described in patients who have received a hematopoietic stem cell transplant (HSCT). We report the experience of 121 consecutive HSCT recipients at a single tertiary care institution in an endemic area. One patient had fatal disseminated coccidioidomycosis after receiving an allogeneic transplant, and 2 patients had pulmonary infection before successful autologous HSCT; 1 of these 2 had a reactivation of coccidioidal infection after HSCT but was treated and survived. coccidioidomycosis was not commonly identified in HSCT recipients, even in the endemic area. A prospective evaluation is required to address the optimal use of coccidioidal serologic tests, antifungal protocols, and secondary prophylaxis in these patients.- - - - - - - - - - ranking = 4.5986419753086keywords = organ (Clic here for more details about this article) |
4/7. Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation.Rare cases of dysimmune phenomena after solid organ transplantation were described in the past. In the present series, we describe six children who developed severe dysimmune anemia or thrombocytopenia while treated with tacrolimus after liver or small bowel transplantation. All patients were off steroids or under low doses alternate day steroid medication when dysimmune cytopenia developed. All patients had positive anti-platelets antibodies and/or Coombs' positive anemia. Therapy was successful in all six patients with a rapid response to corticosteroids in three children, and to anti-CD20 monoclonal antibodies (rituximab) in the three others. The pathogenesis of these rare dysimmune/autoimmune disorders might be related to the interference of tacrolimus with T-cell functions and/or the endogenous control mechanisms of T-lymphocyte activation and down-regulation. Although rare, these complications must be known when discussing protocols of immunosuppression.- - - - - - - - - - ranking = 22.993209876543keywords = organ (Clic here for more details about this article) |
5/7. Transient loss of the Y-chromosome in an elderly man with anemia and lead poisoning: chance occurrence or a clonal marker of the underlying hematological abnormality?One of the most important environmental and occupational pollutants is lead. Cytogenetic damage is known to occur to many individuals exposed to lead, e.g., outdoor and car painters, traffic policemen, gasoline station attendants, etc.1 Chronic lead exposure affects many organ systems leading to a gradual decline in the so-called safe blood lead levels over time.- - - - - - - - - - ranking = 4.5986419753086keywords = organ (Clic here for more details about this article) |
6/7. Sterile neutrophilic folliculitis with perifollicular vasculopathy: a distinctive cutaneous reaction pattern reflecting systemic disease.The authors prospectively encountered skin biopsies from 20 patients which demonstrated a neutrophilic or suppurative and granulomatous folliculitis accompanied by a folliculocentric neutrophilic vascular reaction of Sweet's-like or leukocytoclastic vasculitis subtypes. While in each case the histomorphology raised diagnostic consideration of bacterial folliculitis, patients frequently expressed systemic complaints such as arthritis, fever, and malaise, and special stains for micro-organisms were negative. Among the clinical presentations were folliculitis, vasculitis, acneiform eruptions, vesiculopustular lesions, and erythema nodosum-like lesions, with the legs, arms, and upper back being the most commonly involved sites. Nineteen patients were found to have specific underlying systemic diseases, namely, inflammatory bowel disease, Reiter's disease, Behcet's disease, hepatitis b, connective tissue disease including mixed connective tissue disease and rheumatoid arthritis, scrofuloderma, and hematologic dyscrasias. The other patient had antecedent bacterial sinusitis in the setting of atopy. The folliculocentric nature of these lesions may reflect preferential processing of antigens through the hair follicle and/or homology between bacterial and follicular heat shock proteins in the susceptible host, namely, one who responds excessively to exogenous antigenic triggers. folliculitis with folliculocentric vasculopathy may be a clue to underlying systemic disease and/or an extracutaneous infection. Certain light microscopic features in concert with the clinical presentation may distinguish such cases from conventional infectious folliculitis.- - - - - - - - - - ranking = 4.5986419753086keywords = organ (Clic here for more details about this article) |
7/7. Hematological abnormalities and cholestatic liver disease in two patients with mevalonate kinase deficiency.We describe two patients with mevalonate kinase deficiency and prominent hematologic abnormalities and cholestatic liver disease. Patient R.B. was not anemic at birth, but developed petechiae and cutaneous extramedullary hematopoiesis, hepatosplenomegaly, leukocytosis, and recurrent febrile events without positive bacterial or viral cultures. Patient N.M. manifested minor anomalies, hepatosplenomegaly, anemia, thrombocytopenia, recurrent febrile crises, and facial rashes. Mevalonic aciduria was found by urinary organic acid analysis, and mevalonate kinase deficiency was documented in both. The clinical spectrum of normocytic hypoplastic anemia, leukocytosis, thrombocytopenia, and abnormal blood cell forms led to diagnoses of congenital infection, myelodysplastic syndromes, or chronic leukemia in these patients before recognition of mevalonate kinase deficiency. mevalonate kinase deficiency represents a single-gene abnormality that may be associated with significant hematologic findings. Recognition of the variability of this disorder with some patients manifesting only mild neurologic findings, yet significant hepatosplenomegaly, normocytic anemia, thrombocytopenia, and leukocytosis is important for all specialists who need to be aware of this organic aciduria.- - - - - - - - - - ranking = 9.1972839506173keywords = organ (Clic here for more details about this article) |