1/8. corneal opacity and congenital glaucoma associated with massive heparan sulfaturia: report of one case.A four month-old male infant was noted to have had severe corneal opacity since birth. Buphthalmos, increased intraocular pressure and corneal opacity with neovascularization were noted during physical examination. There was neither dysmorphic face nor hirsutism and the liver and spleen were impalpable. In addition, hypotonia, poor head control, and absence of Moro and grasping reflexes were also noted. There was no evidence of congenital infection by TORCH study. Tests of both urine and plasma amino acids were within normal limits. However, excessive urinary excretion of heparan sulfate was detected by thin-layer chromatography. corneal transplantation was performed at 6 months old. Histopathological examination of the corneal button showed homogeneous thickening of Bowmen's membrane and intracytoplasmic pinkish substances in corneal stroma. The alcian blue stain was positive, which was consistent with mucopolysaccharidosis of cornea. The manifestation of this case may be a clinical variant of Sanfilippo's syndrome (Mucopolysaccharidosis type III).- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
2/8. The art of perimetry.There is no single method of perimetric examination which is applicable to all types of visual field defects. Perimetry is a subjective psychophysical sensory examination. It is not an exact science unless one includes the objective measurement of visual evoked response in the optic cortex. Until such a method becomes clinically available it will be necessary for the perimetrist to determine which techniques to use in a given case and to apply these techniques with sympathetic understanding. This is the art of perimetry.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
3/8. battered child syndrome simulating congenital glaucoma.A 9-week-old child with "congenital glaucoma" was later found to have, in addition to enlarged corneas and elevated intraocular pressure, subluxated and cataractous lenses, hyphema, iridodialysis, angle recession, and vitreous hemorrhage, along with signs of gross parental neglect and physical abuse. To our knowledge, this is the first report in which a battered child with bilateral "congenital glaucoma" (probably caused by trauma) is described.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
4/8. sturge-weber syndrome: A case study.sturge-weber syndrome (SWS) is a rare, sporadic, progressive, congenital syndrome. In its complete trisymptomatic form, SWS is physically characterized by port-wine stains over the trigeminal area, leptomeningeal angiomas usually over the parieto-occipital region, and eye abnormalities. Clinical manifestation for infants with SWS depends on the affected organs, but can include seizures, mental retardation, and glaucoma. This article begins with a case presentation of an infant with SWS and then presents the etiology, embryology, pathophysiology, clinical presentation, management, and prognosis of SWS.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
5/8. Electrophysiological and psychophysical testing of vision in glaucoma.Electrophysiological testing in patients with early glaucoma and in glaucoma suspects reveals defects of central or foveal vision. Most studies suggest that glaucomatous eyes are best separated from normal eyes by use of stimuli with a spatial frequency below the peak of the human contrast sensitivity curve and a relatively high temporal frequency. The stimulus-dependent abnormalities in glaucoma are generally consistent with contrast sensitivity data The stimulus-dependent visual changes are related to the physiology of parallel processing in the primate retinogeniculate pathway.- - - - - - - - - - ranking = 4keywords = physical (Clic here for more details about this article) |
6/8. 'De novo' trisomy 16q11 to pter.A de novo 16q- trisomy was found in a patient with severe mental retardation and mild physical abnormalities. A preliminary delineation the clinical features characteristic of trisomy 16q- is proposed, based upon comparison of the two cases identified so far. The mild phenotypical effects of this chromosome imbalance suggest that the alleged lethality of partial chromosome 16 aneuploidies should be reconsidered.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
7/8. Bleb rupture following filtering surgery with mitomycin-C: clinicopathologic correlations.A 91-year-old woman with a complete rupture of her mitomycin-C filtration bleb associated with eye rubbing while crying was examined. An 18mm soft contact lens was placed preoperatively to re-form the anterior chamber and the patient underwent a conjunctival advancement. Histopathology of the free conjunctival specimen revealed a stratified squamous epithelium with marked attentuation of the subepithelial tissue in the area treated with mitomycin-C. Bleb rupture may be associated with minimal physical trauma following guarded filtration surgery. Successful visual rehabilitation is possible with conjunctival advancement, yet long-term survival of the bleb is poor.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |
8/8. Unrecognized microscopic hyphema masquerading as a closed head injury.OBJECTIVE: To present a child with an unrecognized microscopic traumatic hyphema and acute glaucoma who was initially treated as a closed head injury patient. DESIGN: Case report and discussion. RESULTS: Symptoms attributable to unrecognized occult ocular injury in a child with sickle cell trait resulted in evaluation and treatment of the child for a closed head injury. Evaluation included a computed tomography scan of the head and lumbar puncture. An ophthalmologic consultation later revealed a microscopic hyphema and acute glaucoma as the etiology of the child's signs and symptoms. CONCLUSIONS: Children who present with neurologic symptoms and a history of ocular trauma should undergo an ophthalmologic examination as soon as possible. hyphema, even if not readily visible on physical examination, can result in the development of acute glaucoma with signs and symptoms that resemble a closed head injury.- - - - - - - - - - ranking = 1keywords = physical (Clic here for more details about this article) |