1/46. Cryopathic gangrene with an IgM lambda cryoprecipitating cold agglutinin.Immunochemical and serologic studies of cold agglutinis in patients with chronic cold agglutinin disease (CCAD) have shown the almost exclusive occurrence of IgM kappa antibodies with specificity for the I antigen of red cells. An unusual subgroup of patients has been delineated in which the cryoprotein is IgM lambda, frequently lacks I specificity and often cryoprecipitates. Studies of such a protein from a patient with an unusual array of immunoproliferative disorders including Grave's disease with exophthalmos and Waldenstrom's macroglobulinemia indicate that the cryoprecipitating and cold agglutinating properties probably derive from the sam protein. The occurrence of this type of antibody should suggest the presence of a more aggressive lymphoproliferative disorder than simple CCAD.- - - - - - - - - - ranking = 1keywords = life (Clic here for more details about this article) |
2/46. Life-threatening perineal gangrene from rectal perforation following colonic hydrotherapy: a case report.Alternative medicine is widely publicized in singapore. To date there are few reports of complications arising as a result of such treatments. However, there is no legislation as yet governing alternative medicine practitioners. We present an unusual case of a patient who developed life-threatening perineal gangrene as a result of rectal perforation following colonic hydrotherapy.- - - - - - - - - - ranking = 0.5keywords = life (Clic here for more details about this article) |
3/46. Acute torsion of the gallbladder: review of the literature and report of a case.A case report is presented, and the literature reviewed, of acute torsion of the gallbladder. Originally described as a rare pathological entity, it is being witnessed more frequently as a probable concomitant of increasing life expectancy. Because it is a benign condition if diagnosed rapidly and treated surgically, it should be considered in differential diagnostic possibilities. When encountered intraoperatively, prompt recognition of the process should lead to detorsion of the organ and cholecystectomy as the procedure of choice.- - - - - - - - - - ranking = 0.5keywords = life (Clic here for more details about this article) |
4/46. Platelet apheresis for digital gangrene due to thrombocytosis in chronic myeloid leukaemia.thrombocytosis is a frequent presenting feature of myeloproliferate disorders and is associated with increased incidence of thrombotic and haemorrhage complications. However, these complications are rare in chronic myeloid leukaemia (CML). We describe a case of CML which presented with digital gangrene due to thrombocytosis. Reduction of the platelet count by plateletpheresis lead to rapid symptomatic relief and recovery from the gangrene.- - - - - - - - - - ranking = 0.5keywords = life (Clic here for more details about this article) |
5/46. Tropical idiopathic lower limb gangrene: case report.Tropical idiopathic lower limb gangrene is a rare disease. It was first described by Gelfand amongst the indigenous inhabitants of present day zimbabwe. It is a bilateral and simultaneous gangrene of both lower extremities due to no obvious cause and usually seen in men during the second and fourth decade of life. The onset is always sudden and the first sign is oedema of both feet accompanied by pain. The patients are usually people who have been previously healthy. This is a report of a clinical variant of the disease.- - - - - - - - - - ranking = 0.5keywords = life (Clic here for more details about this article) |
6/46. One pair must last a lifetime. foot care and vascular disease.This is the second in a series of articles on foot care relating to various clinical conditions.- - - - - - - - - - ranking = 2keywords = life (Clic here for more details about this article) |
7/46. gangrene of the toes in a patient with chronic myelogenous leukemia after long-term hydroxyurea therapy.gangrene of the toes and digits appears to be a rare but very severe complication of long-term hydroxyurea therapy. Nothing is known regarding the pathophysiology and the type of vascular damage leading to this syndrome. Here we report a case of a 49-year-old male presenting with gangrene of the toes of both feet 4.5 years after initiation of hydroxyurea therapy for chronic myelogenous leukemia. Blisters on the toes occurred for the first time 9 months prior to hospitalization. Successively, all ten toes showed signs of beginning gangrene with one toe removed surgically 8 months before admission. Presence of diabetes mellitus or peripheral angiopathy was ruled out and platelet counts were within the physiologic range during the last years, excluding thrombocythemia as another rare cause for gangrene in patients with myeloproliferative diseases. Whereas perimalleolar ulcerations of the legs are a more common complication of hydroxyurea, gangrene of the toes as a consequence of hydroxyurea treatment has been described previously only once in the literature. At this point in time cessation of hydroxyurea treatment appears to be the only therapeutic option, thereby avoiding further progress of gangrene in patients with chronic myelogenous leukemia treated with hydroxyurea.- - - - - - - - - - ranking = 0.5keywords = life (Clic here for more details about this article) |
8/46. Derman necrosis due to thrombosis in severe secondary hyperparathyroidism.Two patients had gangrenous dermal necrosis associated with chronic renal disease and secondary hyperparathyroidism. Thromobosed and heavily calcified small arteries were underlying the infarcted areas. One patient had severe hypotension secondary to hemorrhage, which immediately preceded the appearance of dermal lesions. Both patients had notably elevated serum parathyroid hormone and serum alkaline phosphatase levels, as well as severe hyperphosphatemia. Therapy with phosphate binders and calcium and vitamin d supplementation corrected the hyperphosphatemia and reduced serum alkaline phosphatase levels. One patient died; the other patient's dermal lesions healed completely. Localized thrombosis, rather than obliterative intimal proliferation, represents a unique cause of dermal necrosis in this condition.- - - - - - - - - - ranking = 0.5keywords = life (Clic here for more details about this article) |
9/46. Buerger's disease in a 19-year-old woman.A 19-year-old female college student had numbness and the sensation of coldness of her left toes. She had a 3-year smoking history. gangrene of the left foot developed rapidly. angiography revealed peripheral arterial occlusion of both legs and arms. Detailed laboratory examination excluded collagen disease, a hypercoagulable state, and juvenile atherosclerosis. Below-knee amputation of the left leg was performed. Typical histologic findings of Buerger's disease were observed in the crural arteries and saphenous veins. The clinical course was uneventful after the patient stopped smoking. This is the second case report of Buerger's disease in a woman in the second decade of life. It is important that a correct diagnosis of Buerger's disease be established, because the disease process is benign, compared with collagen disease, if the patient stops smoking.- - - - - - - - - - ranking = 0.5keywords = life (Clic here for more details about this article) |
10/46. ecthyma gangrenosum caused by disseminated Exserohilum in a child with leukemia: a case report and review of the literature.We report an 8-year-old boy with acute leukemia who developed ecthyma gangrenosum secondary to infection with Exserohilum spp., a rare cause of human disease. The skin, paranasal sinuses and lungs were involved. To the best of our knowledge, this is the first report of ecthyma gangrenosum caused by Exserohilum spp. This case emphasizes the importance of prompt skin biopsy for early diagnosis and treatment of this life-threatening infection.- - - - - - - - - - ranking = 0.5keywords = life (Clic here for more details about this article) |
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