1/3. amnion degeneration over fetal placental surface vessels possibly resulting from focal hypoxia: a case report.The monoamnionic placenta of this twin gestation had focal amnion necrosis, but this was present only over the fetal surface vessels of one twin; this twin also developed cerebral atrophy. We hypothesize that this degeneration is due to a more severely reduced oxygen tension in its vessels. The placental amnion epithelium may undergo several degenerative processes, including amnion nodosum and changes due to meconium staining. Sonography had disclosed what appeared to be a dividing membrane, but this was not found at birth when monoamnionic twins with entangled cords presented. The amnion degeneration was present only over the large surface fetal vessels of the placenta of that twin who also developed central nervous system degeneration, and macrophage infiltration was confined to the same lesions. Focal hypoxia from entangling cords may have caused this defect.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
2/3. Severe fetal brain injury without evident intrapartum asphyxia or trauma.Two appropriate-for-dates term infants were born after uncomplicated labors and atraumatic deliveries. They were depressed at birth, developed seizures on the first day of life, and followed clinical courses compatible with hypoxic-ischemic encephalopathy. However, the umbilical cord vessel pH and blood gases were normal. The children are now severely retarded and have cerebral palsy. These cases prove that the events of labor and delivery may not be responsible for all cases of brain damage in surviving children.- - - - - - - - - - ranking = 0.14285714285714keywords = vessel (Clic here for more details about this article) |
3/3. Quantitative morphometric analysis of the pulmonary arteries in two patients with D-transposition of the great arteries and persistence of the fetal circulation.Quantitative morphometric studies were performed on the pulmonary arteries of two newborns who died at 1 and 3 days of age with both transposition of the great arteries and persistence of the fetal circulation. Similar studies were performed on two normal control subjects (age 2 and 6 days), one newborn infant (age 1 day) with secondary persistence of the fetal circulation, and one newborn infant (age 2 days) with isolated D-transposition of the great arteries, as compared to those without it. When wall thickness was related to external diameter of the vessel, the greatest difference in thickness was observed in the smallest vessels (less than 150 mu in diameter). Extension of smooth muscle peripherally and to the smallest vessels (less than 50 mu) was similarly most marked in those infants with persistence of the fetal circulation may coexist but at the same time be unrelated in a single patient. Furthermore when such coexistence is unrecognized, pharmacologic manipulation of the ductus arteriosus may be hazardous.- - - - - - - - - - ranking = 0.42857142857143keywords = vessel (Clic here for more details about this article) |