1/10. Conjunctival intraepithelial neoplasia presenting as corneal ulcer.PURPOSE: To report a case of conjunctival intraepithelial neoplasia presenting as corneal ulcer. METHOD: Case report of a 28-year-old man who presented with sudden onset of pain, redness, and watering in the right eye. Examination of right cornea revealed deep stromal infiltrate inferonasally. Adjacent to the infiltrate and straddling the inferonasal limbus, a reddish well-defined sessible lesion with prominent blood vessels was seen. After corneal scraping for microbiological evaluation, the patient was treated with frequent instillation of ciprofloxacin hydrochloride 0.3% eyedrops. RESULTS: Corneal scraping revealed no microorganisms. Infiltrate resolved promptly after excision of the lesion. Histopathologic evaluation of the excised lesion revealed conjunctival intraepithelial neoplasia. CONCLUSIONS: This case highlights the fact that conjunctival intraepithelial neoplasia at the limbus may present as corneal ulcer. This ulcer could have occurred secondary to a dellen formation and epithelial breakdown predisposing to a corneal ulcer.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
2/10. Differentiation of pigmented conjunctival squamous cell carcinoma from melanoma.A 69-year-old man developed a pigmented conjunctival tumor that had a papillomatous vascular configuration but no leukoplakia. Although the pigmentation suggested melanoma clinically, histopathologic study of the resected lesion disclosed squamous cell carcinoma, with scattered dendritic melanocytes in the tumor. Conjunctival squamous cell carcinoma can be pigmented, similar to melanoma. The papillomatous arrangement of blood vessels in such tumors should strongly suggest squamous cell carcinoma despite the absence of leukoplakia.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
3/10. Treatment of conjunctival squamous cell carcinoma with photodynamic therapy.PURPOSE: The aim of this study was to describe the clinical and angiographic response of squamous cell carcinoma (SCC) of the conjunctiva to treatment with photodynamic therapy (PDT). DESIGN: Interventional case series. methods: In a prospective study, three patients (62 to 86 years old) with SCC of the conjunctiva were treated with PDT. patients received one to three treatments of verteporfin (6 mg/m(2) body surface area, intravenously). The light dose was calculated as 50 J/cm(2). All tumors were irradiated 1 minute after injection. The mean follow-up time was 8.6 months (7 to 12 months). Main outcome measurements were clinical and angiographic response and treatment-related side effects. RESULTS: One week after treatment, angiographic occlusion of tumor vasculature and normal conjunctival vessels was observed in all patients. Tumor regression was noted in all patients 1 month after treatment. Two patients had complete regression (clinical and angiographic observation) after one or two treatments for the entire follow-up time. One tumor involved large aspects of the conjunctiva and cornea. In this case, only the treated areas showed tumor regression. PDT caused minimal temporary local irritation in two patients, and small conjunctival hemorrhages and mild transient chemosis in the three eyes directly after treatment. One patient had infusion-related back pain. CONCLUSION: The preliminary results of this study suggest that PDT may be a valuable addition to the treatment of patients with SCC of the conjunctiva. However, longer follow-up is necessary to assess the duration and degree of tumor control.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
4/10. Superficial adnexal lymphangioma.An 11-year old girl presented with a painless fleshy lesion involving the plica, caruncle and medial bulbar and palpebral conjnctiva of the right eye since birth. The patient underwent debulking and cryotherapy. biopsy showed lymphatic vessels lined with one flattened layer of endothelial cells devoid of smooth muscles or pericytes. Most of the lumens contained pink amorphous lymph with lymphoid aggregates.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
5/10. Human herpesvirus-8 in Kaposi's sarcoma of the conjunctiva in a patient with AIDS.PURPOSE: To demonstrate human herpesvirus-8 (HHV-8) in Kaposi's sarcoma (KS) of the conjunctiva in a patient with acquired immunodeficiency syndrome (AIDS). methods: Clinical observation, pathologic findings of conjunctival specimens, immunohistochemical staining for HHV-8-specific antigen, polymerase chain reaction (PCR) analysis of HHV-8 dna, and detection of specific antibody in patient's serum at appropriate times. RESULTS: In the conjunctival specimen, swollen endothelial-like cells were found with slit-like vessels. CD 31-positive cells were noted on the inner surface of the slit-like vessels, and HHV-8 latency-associated nuclear antigen was detected. The presence of HHV-8 dna was demonstrated by PCR. Anti-HHV-8 antibody was found in the patient's serum. CONCLUSIONS: This is the first case report in the ophthalmology literature that provides histological, dna, and serological evidence that HHV-8 is involved in the pathogenesis of conjunctival KS.- - - - - - - - - - ranking = 2keywords = vessel (Clic here for more details about this article) |
6/10. Orbital-conjunctival glomangiomas involving two ocular rectus muscles.PURPOSE: To report two glomangiomas in one orbit, each isolated to a rectus muscle. DESIGN: Clinicopathologic correlation. methods: A 12-year-old boy developed two separate vascular tumors, near the insertions of the medial rectus and superior rectus muscles, respectively. A biopsy of one tumor was studied by light microscopy and immunohistochemistry. RESULTS: Histopathology revealed blood vessels surrounded by cuboidal cells characteristic of glomangioma. The cells showed immunoreactivity for smooth muscle actin and vimentin, supporting the diagnosis. CONCLUSIONS: Glomangioma can involve the rectus muscles in the conjunctiva and orbit, and should be considered in differential diagnosis of vascular tumors in the ocular region.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
7/10. Case of conjunctival liposarcoma.A case of primary conjunctival liposarcoma was reported. The patient was a 62-year-old woman who complained of swelling of the left bulbar conjunctiva. As the swelling lesion did not respond to treatment and had gradually enlarged, surgical excision was performed 18 months after her first visit. The tumor was bean-sized and was located subconjunctivally without connecting orbital tissues. Histopathological examination of the specimen revealed numerous neoplastic cells containing stellate and hyperchromatic nucleus. The cytoplasm of these cells contained vacuoles resembling lipid droplets. Signet-ring type cells were also observed. These cells were considered to be lipoblasts. The stroma was myxomatous and thin-walled vessels were observed. The present tumor was confirmed by histopathological study as myxoid liposarcoma and considered to be of bulbar conjunctiva origin. The patient showed no sign of recurrence during 16 months of follow-up.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
8/10. Orbital-adnexal lymphangiomas. A spectrum of hemodynamically isolated vascular hamartomas.A retrospective review of 13 cases of lymphangioma has led to a classification of these lesions into categories of superficial, deep, and combined types. The clinical manifestations, prognosis, and management directly correlate with the pathophysiology and the location of the lesions. Superficial lesions consist of isolated multicystic vascular abnormalities of cosmetic significance only. Deep orbital lymphangiomas present as spontaneous, acute proptosis due to retrobulbar hemorrhage. Combined lesions demonstrate both superficial and deep components and are also characterized by spontaneous hemorrhages. Histopathologically, lymphangiomas represent a spectrum of vascular hamartomas with a constellation of features that parallels the clinical progression and histology of similar lesions elsewhere in the head and neck. This may include the presence of diaphanous serous-filled vascular channels, a connective tissue stroma with lymphorrhages, features of old hemorrhage, dysplastic vessels, and random smooth muscle bundles. Both direct and indirect evidence suggests that these lesions are characterized by relative hemodynamic isolation.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
9/10. Multicentric Kaposi's sarcoma of the conjunctiva in a male homosexual with the acquired immunodeficiency syndrome.A 38-year-old male homosexual with the new acquired immunodeficiency syndrome (AIDS) had biopsy proven Kaposi's sarcoma of the right palpebral conjunctiva, extraocular mucocutaneous areas, and lymph nodes. Histologically, the palpebral tumor was characterized by atypical spindle cell proliferation and multiple slit-like vessels. Staining for factor viii-related antigen was positive in the cytoplasm of some tumor cells. Electron microscopy disclosed weibel-palade bodies in cells lining scattered slit-like vascular channels. The palpebral tumor mass was relatively nonadherent to its surrounding tissues and thus its simple excision was noteworthy; despite the prominent vascularity of the tumor, minimal bleeding was associated with its surgical resection. Any patient with AIDS should have all mucosal surfaces routinely examined for the presence of Kaposi's sarcoma lesions.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
10/10. Primary basal cell carcinoma of the caruncle.We describe a 24-year-old man with primary basal cell carcinoma of the caruncle. Clinically the lesion was a whitish, slightly prominent nodule surrounded by fine vessels. No associated cutaneous lesion and no connection to the surrounding skin was present. The lesion was subsequently completely excised, and histopathological examination revealed a solid-cystic basal cell carcinoma of the caruncle. Primary basal cell carcinoma of the caruncle is an extremely rare but distinct entity. To our knowledge, review of the literature has not demonstrated a previous photographically documented case of primary basal cell carcinoma of the caruncle.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
| | Next -> |