1/19. Acquired reactive perforating collagenosis associated with diabetes mellitus: eight cases that meet Faver's criteria.Reactive perforating collagenosis (RPC) is characterized by umbilicated papules with a central adherent keratotic plug. Histologically, this condition shows transepidermal elimination of altered dermal collagen bundles into a cup-shaped epidermal depression. The present paper describes eight patients with associated diabetes mellitus who meet the diagnostic criteria for the acquired form of RPC (ARPC). Although half of these patients underwent dialysis, the lesions did not tend to develop after dialysis. pruritus and the Koebner phenomenon were common, and histologically a microvasculopathy was noted in the dermis of all patients. We speculate that this disease is triggered by a cutaneous response to superficial trauma. Furthermore, this response acts synergistically with vasculopathy in the dermis, primarily in the case of diabetes mellitus. A secondary sign of ARPC may be degenerated collagen fibres as a result of transepidermal elimination.- - - - - - - - - - ranking = 1keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
2/19. Treatment of pruritis of reactive perforating collagenosis using transcutaneous electrical nerve stimulation.Reactive perforating collagenosis is a form of perforating dermatosis due to transepithelial elimination of collagen and characterized by itchy papulonodular eruptions frequently seen in patients with diabetes mellitus and end stage renal failure. pruritus is often severe and treatment is difficult. Two adult Chinese diabetic patients with acquired reactive perforating collagenosis unresponsive to topical therapies and oral antihistamines, were treated with transcutaneous electrical nerve stimulation. There was a significant reduction of itch followed by gradual resolution of the skin lesions.- - - - - - - - - - ranking = 0.16666666666667keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
3/19. Acquired reactive perforating collagenosis in a diabetic patient with pulmonary aspergillosis.Reactive perforating collagenosis (RPC) is a rare disorder characterized by transepidermal elimination of altered collagen. The acquired form of RPC manifests in adult life and is accompanied by general pruritus and scratching. diabetes mellitus and end-stage renal disease are frequently associated with RPC. We describe a case of RPC developing after pulmonary aspergillosis in a 54-year-old man with long-standing insulin-dependent diabetes and discuss possible etiologic relations.- - - - - - - - - - ranking = 0.041868505271454keywords = mellitus, diabetes (Clic here for more details about this article) |
4/19. Treatment of perforating collagenosis of diabetes and renal failure with allopurinol.We present a case of widespread reactive perforating collagenosis in a 63-year-old woman undergoing haemodialysis after diabetic nephropathy, who was treated successfully with allopurinol. The patient responded well and rapidly to a dose of 100 mg allopurinol daily. It is suggested that more patients with reactive perforating collagenosis may benefit from allopurinol therapy.- - - - - - - - - - ranking = 0.056179898959218keywords = diabetes (Clic here for more details about this article) |
5/19. Acquired reactive perforating collagenosis.Acquired perforating disorder has been recognized as an uncommon distinct dermatosis in which altered collagen is eliminated through the epidermis. Several disorders accompanied by itching and scratching were reported to be associated with reactive perforating collagenosis. A 67-year-old white woman diagnosed as acquired reactive perforating collagenosis with poorly controlled diabetes mellitus and congestive cardiac failure is presented.- - - - - - - - - - ranking = 0.16666666666667keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
6/19. Reactive perforating collagenosis: a condition that may be underdiagnosed.Reactive perforating collagenosis is a perforating disorder developing in adults, usually in association with diabetes mellitus or renal failure. We present three cases diagnosed at the Royal Prince Alfred Hospital in a 5 month period. All three patients had long-standing diabetes mellitus, hypertension, hypercholesterolaemia and ischaemic heart disease. Each patient presented with generalized pruritus and a papular eruption across the trunk and limbs. More than one biopsy or multiple levels were needed before the diagnostic histological features were seen. The first patient responded to 0.5% phenol with 10% glycerine in sorbolene cream. The second patient did not respond to topical betamethasone diproprionate 0.5 mg/g cream and antihistamines (hydroxyzine 25 mg nocte) and required narrow-band ultraviolet (UV) B. The third patient, having failed to respond to topical betamethasone diproprionate 0.5 mg/g cream and wet dressings, antihistamines (hydroxyzine 25 mg tds and doxepin 50 mg nocte) and UVB required acitretin 25 mg orally per day. Because reactive perforating collagenosis responds to treatment, we believe this condition should be considered in patients with diabetes mellitus or renal failure presenting with pruritus and that biopsy of intact lesions may need multiple levels to help establish the diagnosis.- - - - - - - - - - ranking = 0.5keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
7/19. A case of idiopathic nodular glomerulosclerosis mimicking diabetic glomerulosclerosis (Kimmelstiel-Wilson type).A case of idiopathic nodular glomerulosclerosis mimicking diabetic Kimmelstiel-Wilson glomerulopathy is reported. The patient was a 45-year-old man suffering from nephrotic syndrome. light and electron microscopy revealed diffuse and nodular glomerulosclerosis indistinguishable from diabetic nodular glomerulosclerosis. diabetes mellitus, however, had been excluded both by extensive clinical and by laboratory investigation. The differential diagnosis also included amyloidotic and non-amyloidotic fibrillary glomerulopathy, light chain glomerulopathy, collagen type iii disease, immunotactoid glomerulopathy, and the sclerosing variant of membranoproliferative glomerulonephritis. immunohistochemistry and ultrastructural investigations, however, excluded these entities, and the diagnosis of idiopathic nodular glomerulosclerosis was made. This variant has to be included in the differential diagnosis of nodular glomerulopathy associated with nephrotic syndrome.- - - - - - - - - - ranking = 0.02782353053165keywords = mellitus (Clic here for more details about this article) |
8/19. Acquired reactive perforating collagenosis: report of a case and review of the literature.A case of acquired reactive perforating collagenosis is reported in a 57-year-old Thai woman, with a history of diabetes mellitus, chronic renal insufficiency needing hemodialysis, and dry gangrene of the right fourth toe. physical examination revealed multiple scattered erythematous hyperkeratotic nodules and plaques and some showed ulceration. Histopathology showed vertical strands of collagen perforating from the ulcerated lesions. The authors also reviewed the literature on this subject.- - - - - - - - - - ranking = 0.16666666666667keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
9/19. Cutaneous mucormycosis secondary to acquired reactive perforating collagenosis.Acquired reactive perforating collagenosis (ARPC) is a rare perforating disease of the skin. It is characterized by hyperkeratotic papules with transepidermal elimination of degenerated material including collagen and elastic fibers. The disease presents clinically as umbilicated papules with a central adherent keratotic plug. mucormycosis infection, caused by the molds of the class Zygomycetes and order mucorales, generally occurs as an opportunistic infection. It presents most frequently in patients with diabetes mellitus, in patients with leukemia receiving chemotherapy, and in those on sustained immunosuppressive therapy. We describe a patient with type 2 diabetes mellitus and end-stage renal disease requiring hemodialysis in whom extensive cutaneous mucormycosis with secondary spread to the brain, lumbar spine, and breast developed in the setting of ARPC. To our knowledge, this is the first case report of a patient with ARPC who developed extensive cutaneous mucormycosis.- - - - - - - - - - ranking = 0.33333333333333keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
10/19. Reactive perforating collagenosis associated with scabies in a diabetic.Reactive perforating collagenosis (RPC) in adults commonly manifests in patients with diabetes mellitus. pruritus and consequent induced scratching have been identified as the bases for the evolution of this skin disease. We present the unusual case of a 55-year-old female diabetic with characteristic umbilicated skin lesions and a long history of scabies. histology from a crusty nodule revealed transepidermal elimination of collagen. Following antiscabietic treatment, two courses of oral doxycycline demonstrated beneficial effects in controlling the perforating skin disorder.- - - - - - - - - - ranking = 0.16666666666667keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
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