1/258. Intra-articular metastatic melanoma of the right knee.melanoma can metastasize to almost every organ and tissue. Although bone metastases have been reported frequently, the authors are aware of only a single report of intra-articular synovial metastasis. A case of metastatic melanoma, mimicking degenerative medial meniscal tear of the right knee, is presented. Further examination revealed asymptomatic metastases in the liver, subcutaneous tissue, and left trochanter minor. Arthroscopic examination revealed widespread synovial metastasis and a palliative arthroscopic synovectomy was performed.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
2/258. bone marrow metastases in disseminated alveolar rhabdomyosarcoma: case report with ultrastructural study and review.A case of desseminated alveolar rhabdomyosarcoma in an 18-year-old male with leuco-erythroblastic anaemia is described. Numerous bizarre malignant cells, including frequent multinucleated giant cells, were seen in bone marrow aspirates, and osteolytic lesions appeared late in the clinical course. The primary site of the neoplasm remained undertermined during life and also at necropsy, which revealed minute pulmonary metastases and extensive lymph nodal, pleural and skeletal deposits. The diagnosis was confirmed on necropsy tissue by ultrastructural examination which demonstrated numerous thin (5 nm) and thick (15 nm) intracytoplasmic filaments in tumour cells, sometimes organized in bundles; scattered dense Z-band-like bodies, and rod-shaped structures were also seen. The fine structure of the rhabdomyosarcoma in the present case is compared with previous ultrastructural studies. Elongated, thick intracytoplasmic filaments whose diameter corresponds to that of myosin myofilaments are strong evidence for rhabdomyoblastic differentiation and are considered to be the sine qua non of a positive electron microscopic diagnosis of rhabdomyosarcoma. Orgaized bundles of filaments and Z-band-like dense bodies are usually present, and rod-shaped structures are found infrequently, but none of these are necessary for the ultrastructural diagnosis.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
3/258. Delayed methotrexate clearance in a patient with sickle cell anemia and osteosarcoma.A 15-year-old girl with homozygous sickle cell anemia (HbSS) and osteosarcoma is described. Delayed clearance of methotrexate (MTX) after the second course of high-dose MTX (HDMTX) led to the development of renal and hepatic toxicities. Rescue was accomplished with high-dose leucovorin, intravenous carboxypeptidase G2, and thymidine. Although the renal and hepatic abnormalities resolved, focal tonic-clonic seizures developed, accompanied by abnormal brain imaging. Four weeks after this episode, all clinical and biochemical abnormalities resolved. Preexistent end-organ damage associated with HbSS may compromise the ability to deliver high-dose chemotherapy with curative intent in patients with malignant disease.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
4/258. Intraosseous epithelioid malignant peripheral nerve sheath tumor of the phalanx. Case report.We report the first case of intraosseous epithelioid malignant peripheral nerve sheath tumor (MPNST) occurring in the phalanx. The patient was a 50-year-old Japanese man with an intramedullary lytic lesion of the proximal phalanx. Microscopically, the tumor was composed of epithelioid cells or polygonal cells, forming large cell nests with central necrosis. Most tumor cells were diffusely and strongly immunopositive for S-100 protein and vimentin, and negative for cytokeratin, epithelial membrane antigen, carcinoembryonic antigen, alpha-smooth muscle actin, and HMB-45. laminin-positive material was discontinuously demonstrated between the individual tumor cells. Electron microscopy showed prominent external lamina. Our case indicated that laminin is useful for differentiating epithelioid MPNST from metastatic carcinoma and malignant melanoma.- - - - - - - - - - ranking = 32.693229915973keywords = nerve (Clic here for more details about this article) |
5/258. US and CT findings of multicentric leiomyosarcomatosis.This article presents a case of leiomyosarcomatosis with widespread lesions involving the soft tissues and the most unlikely organs such as thyroid and salivary glands, pancreas, ligamentum teres, bladder wall, and bones without lymph node or distant metastasis. The CT and US findings of this rare phenomenon are discussed with regard to the literature.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
6/258. Small cell osteogenic sarcoma of the ribs: cytological, immunohistochemical, and ultrastructural study with literature review.Small cell osteosarcoma (OS) is a rare variant of OS that is composed of small cells resembling those of Ewing's sarcoma (ES) with recognizable osteoid. This type of tumor often creates difficulty in making a diagnosis when tissue samples do not include osteoid. The frequent sites are long bones and until now there have been no reported cases arising in the ribs. A case is reported here of small cell OS occurring in the ribs of a 37-year-old female with its aspiration cytologic and electron microscopic characteristics. In the cytologic smear, the small round neoplastic cells were individually scattered or arranged in small nests. The nuclei were hyperchromatic and oval with no visible nucleoli. Ultrastructurally, the nuclei had a round or oval euchromatic chromatin pattern and occasional nucleoli. The scanty cytoplasm contained a small quantity of organelles including either tubular or dilated cisternae of RER, a few mitochondria, and free or polyribosomes. Other organelles were absent. Although the electron microscope sample of this case did not include bone mineral (hydroxy apatite), the electron microscopic features of the tumor cells were unique and useful for exclusion of other small round cell neoplasms.- - - - - - - - - - ranking = 2keywords = organ (Clic here for more details about this article) |
7/258. dna ploidy alterations detected during dedifferentiation of periosteal chondrosarcoma.dna ploidy of a case with dedifferentiated periosteal chondrosarcoma was analyzed by dna cytofluorometry. The diagnosis of primary periosteal chondrosarcoma was made on the basis of the radiographic and histological findings. At 4 years after marginal resection, the tumor recurred locally and metastasized to various organs. The patient died of disease 2 years later. Histologically, there were two components, chondrosarcoma and malignant fibrous histiocytoma, in the recurrent and metastatic tumors. dna ploidy analysis of multiple samples revealed that the primary lesion was composed of many diploid cells with some tetraploid and octaploid cells, whereas in the dedifferentiated area, there were many aneuploid cells which were not recognized in any area of the primary tumors. This case illustrated that dna ploidy alteration of euploidy to aneuploidy is closely correlated with the process of dedifferentiation in chondrosarcoma.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
8/258. Multiple diffuse fibrosarcoma of bone.Multiple diffuse fibrosarcoma of bone is a very rare condition, with only 3 cases reported. Its presentation is like that of a multiple myeloma or a metastatic tumor, with multiple osteolytic lesions, and its extent is limited to the bones. Disseminated involvement of the vertebrae was detected in a 26-year-old man, suggesting a metastatic tumor; however, no primary organ or soft-tissue mass was identified. The histopathologic findings of the biopsy material were consistent with fibrosarcoma. Despite treatment, the patient died within 15 months.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
9/258. Disseminated lymphangiomatosis presenting with massive chylothorax.BACKGROUND: Lymphangiomatosis is a disease characterized by involvement of various body constituents and can involve the skeletal system, connective tissues, and visceral organs. MATERIALS AND methods: We present a case of a 9-year-old girl where this entity presented with extensive right-sided chylothorax. Conventional imaging, including skeletal scintigraphy and contrast enhanced CT of the chest and abdomen, may have underestimated the extent of the disease, as seen on follow-up T2-weighted MR images of the chest and abdomen in our case. RESULTS: MRI easily demonstrated additional bone lesions as well as multiple small splenic lesions, which were difficult to appreciate on prior CT examinations. CONCLUSION: We suggest that MRI may be helpful to assess the extent of this disease more accurately.- - - - - - - - - - ranking = 1keywords = organ (Clic here for more details about this article) |
10/258. Isolated musculocutaneous neuropathy caused by a proximal humeral exostosis.We report an isolated musculocutaneous neuropathy caused by a proximal humeral osteochondroma that became symptomatic after the patient played recreational basketball. Lesion resection resulted in complete deficit resolution. Mass lesions involving the musculocutaneous nerve should be considered in patients with atraumatic, isolated musculocutaneous neuropathies that are recurrent or fail to recover, even in the setting of strenuous exercise.- - - - - - - - - - ranking = 6.5386459831947keywords = nerve (Clic here for more details about this article) |
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