1/2. The localization of memory.MRI showed severe lesions, thought to be specific for the Wernicke-korsakoff syndrome, in an alcohol dependent patient with an excellent memory. The morphological abnormalities thought to be typical of Wernicke-korsakoff syndrome might be features of chronic alcoholism and malnutrition. This contention has important implications for the localization of memory functions. Recent literature on the anatomical basis and mechanism of memory is reviewed. memory probably resides in multifocal neural networks rather than in specific anatomical sites.- - - - - - - - - - ranking = 1keywords = malnutrition (Clic here for more details about this article) |
2/2. Central pontine myelinolysis associated with low potassium levels in alcoholism.Two patients with chronic alcohol abuse and central pontine myelinolysis are described. One developed a korsakoff syndrome 2 days before admission to our hospital and the other showed signs of a incipient delirium without korsakoff syndrome. diagnosis of incipient central pontine myelinolysis was based on acute brain-stem dysfunction, serum electrolyte disturbances, malnutrition with vitamin B1 (thiamine), B6 (pyridoxine) and B12 (cyanocobalamin) deficiency in combination with typical neuroradiological findings. Hypokalaemia but no disturbance in serum sodium levels was found in both patients. After correction of hypokalaemia and vitamin deficiency the patients showed complete recovery of neurological and neuropsychological function. The findings are interpreted as suggesting that disturbances in serum potassium levels as well as rapid correction of hyponatraemia may be associated with pontine swelling and dysfunction which, if undetected, leads to central pontine myelinolysis.- - - - - - - - - - ranking = 1keywords = malnutrition (Clic here for more details about this article) |