1/10. adenoma malignum. Report of a case with cytologic and colposcopic findings and immunohistochemical staining with antimucin monoclonal antibody HIK-1083.BACKGROUND: adenoma malignum of the uterine cervix was first described by Gusserow. We report here a case with cytologic, histologic and colposcopic findings and immunohistochemistry for HIK-1083. CASE: A 42-year-old female was noted to have a probable adenoma malignum due to the detection of atypical cells classified as V. On colposcopy, comma-shaped, atypical vessels spread over the entire cervical area. Histologic findings were characteristic of tumor invasion beyond the layer of cervical glandular ducts. Immunohistochemical detection of CEA was negative, but HIK-1083, which recognizes gastric glandular mucous cells, was positive. CONCLUSION: For a definitive diagnosis of adenoma malignum of the cervix, immunohistochemical examination for an appropriate marker, such as HIK-1083, should be added to the routine gynecologic examination, cytologic and histopathologic examination, and colposcopy.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
2/10. Extended surgery with en bloc resection of the right common iliac vessels for lymph node metastasis of mucinous colon carcinoma: report of a case.We report herein the case of a 63-year-old woman who underwent surgery for recurrent mucinous carcinoma of the cecum. Recurrent metastatic lymph nodes had invaded the right common iliac vessels and right ureter, but she had no distant metastases and no peritoneal dissemination. Extended surgery with en bloc resection of the right iliac vessels and right ureter, and femorofemoral bypass were performed. Postoperatively, several complications developed which were successfully treated by further operations. By 1 year after surgery, she had no recurrent tumors on radiological examination, suggesting that our aggressive surgery with resection of the invaded regional vessels had effectively removed the recurrent tumors. This procedure may therefore significantly prolong the survival time and improve the quality of life of such patients.- - - - - - - - - - ranking = 7keywords = vessel (Clic here for more details about this article) |
3/10. Total dorsal pancreatectomy for intraductal papillary mucinous neoplasm in a patient with pancreas divisum.We report a case of intraductal papillary mucinous neoplasm confined to the dorsal (Santorini) pancreatic duct. A 51-year-old woman presented with a cystic lesion in the head of her pancreas and pancreas divisum. A biopsy taken during cyst-enteric drainage revealed dysplastic epithelium so the patient was scheduled for resection. At operation, excision of the entire dorsal pancreas was performed with preservation of the unaffected ventral pancreas and the spleen and its vessels. Over 6 years later she remains well with stable weight and a good quality of life. This case illustrates the benefits of anatomical preservation in pancreatic resection, and was performed some years prior to the only other reported similar case.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
4/10. Epidermotropically metastatic pancreatic adenocarcinoma.We describe an epidermotropically metastatic pancreatic mucinous ductal adenocarcinoma on the scalp. Neoplastic glandular structures that varied in size and shape containing abundant mucin within the lumens and in the neoplastic cells were present within a seborrheic keratosis and adjacent normal epidermis. Similar neoplastic glandular structures were present in the dermis, some within adnexal epithelium and lymphatic vessels. The patient's history of pancreatic mucinous ductal adenocarcinoma and immunohistochemical staining pattern of carbohydrate antigen 19-9 (CA 19-9) confirmed the diagnosis.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
5/10. brain and skull metastases of hepatic or pancreatic cancer--report of six cases.brain and skull metastases from primary hepatic or pancreatic cancer are very rare. The authors describe six cases of metastatic tumors. These are skull (three cases) and brain (one) metastasis of hepatic cancer and brain metastasis (two) of pancreatic cancer. In three hepatic cancer patients, the metastatic lesions were diagnosed before the diagnosis of primary cancer. In these patients, plain skull x-ray showed osteolytic lesions and vascular enlargement. A postcontrast computed tomographic (CT) scan showed an enhanced high-density epidural mass. Angiograms showed a tumor stain fed by abnormal vessels from the external carotid artery. In one patient with a metastatic brain tumor from hepatic cancer, a CT scan showed a high-density mass with hematoma. In one of the brain metastases from pancreatic cancer, a CT scan revealed a cystic, ring-like enhanced lesion in the thalamus. In the other case, a CT scan showed an isodensity mass in the vermis and hydrocephalus. Metastatic tumors from primary hepatic cancer were soft and hemorrhagic, but they were clearly demarcated from the surrounding tissue. In the case of thalamic metastasis, the cyst content was aspirated and an anticancer agent was administered into the cystic cavity. In the other cases, the tumors were totally removed. The outcome was very poor in all cases.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
6/10. Cerebrovascular complications of mucinous cancers.Six patients with mucinous cancer (2 colonic, 2 pancreatic, and 2 pulmonary origin) had necropsy evidence of thrombosis of large and small systemic, extracranial, and intracranial arteries and veins, and multiple cerebral infarcts and small hemorrhages. On microscopic examination, we found small infarcts and hemorrhages within the brain and mucin within vessels, macrophages, and in areas of infarction. The clinical picture included strokes and encephalopathy. Mucin-producing cancers can be associated with a coagulopathy that causes extensive occlusive vascular disease.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
7/10. Primary mucinous carcinoma of the skin with metastases to the lymph nodes.Primary mucinous carcinoma is a rare sweat-gland neoplasm of the skin with a tendency to grow slowly. Although the neoplasm persists locally in nearly half of the cases after attempts at removal, metastases to regional lymph nodes and widespread metastases are uncommon. We present a case of primary mucinous carcinoma in an axilla with metastases to the axillary lymph nodes and propose a hypothesis explaining the slow rate of growth, based on our findings of a paucity of both blood vessels and macrophages in the neoplasm. Electron microscopy revealed mucin production by the dark cell and its extracellular secretion, which supports the theory of eccrine differentiation of the neoplasm.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
8/10. Hemorrhagic infarcts caused by mucin emboli mimicking brain purpura.The macroscopic aspect of brain purpura was mimicked by multiple hemorrhagic infarcts arising in the vascular supply region of small arteries occluded by embolized mucin in a case of scar adenocarcinoma of the right lower pulmonary lobe, which had extensively permeated pulmonary blood vessels. The pathophysiology is discussed along with its clinical implications.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
9/10. Hyperviscosity syndrome in disseminated breast adenocarcinoma.Circulation within the bloodstream of mucin derived from mucin-producing adenocarcinomas has been documented infrequently but has been associated with vascular occlusion, organ infarction, and hyperviscosity. The nature of the mucin and the therapeutic role of plasmapheresis in this condition has not been reported. A 64-yr-old female, who had undergone a mastectomy 3 yrs previously for an infiltrating mucinous breast adenocarcinoma, presented with dementia. A blood film showed marked rouleaux and a bluish background. No abnormal bands were detected on plasma protein electrophoresis. Blood, serum and plasma viscosity were above the range of readability of the viscometer. A bone marrow biopsy showed replacement with tumor similar to the original. Repeated plasmaphereses substantially reduced viscosity and temporarily improved her mental state. Post mortem revealed numerous infarcts with eosinophilic mucoid material in the lumen of many small vessels. That the offending plasma constituent was a sialomucin was suggested by mucin stains of the tumor and peripheral blood, a plasma sialic acid level 10 x normal and a substantial fall in viscosity after in vitro treatment of plasma with neuraminidase.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
10/10. Non occlusive ileocaecocolic intussusception caused by caecum cancer--case report.A case of ileocaecocolic intussusception caused by a caecum carcinoma is presented. The authors stress the peculiarity of clinical manifestation, without intestinal obstruction despite the presence of a big abdominal mass involving vessels and bowel, revealed by CT scanning and angiography. endoscopy was not able to identify the nature of the lesion. laparotomy performed with the idea to find a mesenchymal neoplasia, permitted to achieve the diagnosis.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
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