1/4. prenatal diagnosis of methotrexate embryopathy.BACKGROUND: methotrexate is an antineoplastic agent used by obstetrician-gynecologists for termination of early pregnancy. The drug is not always successful and is associated with a known array of malformations. CASE: We present a case of a failed pregnancy termination with methotrexate, which resulted in fetal anomalies. Ultrasound revealed absent or markedly shortened long bones, abnormal positioning of the hands, micrognathia, echogenic bowel, and a two-vessel umbilical cord. The patient elected to undergo pregnancy termination, and the ultrasound findings were confirmed at autopsy. CONCLUSION: Because of methotrexate's teratogenic potential, follow-up to confirm successful termination is necessary. Ultrasound evaluation of the fetus is indicated if pregnancy termination is unsuccessful.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
2/4. An abnormality in the human cochlear vasculature in a case of cis-platinum ototoxicity.The histopathological findings of a study of a human temporal bone are reported. The subject of this study was treated with cis-platinum in combination with bleomycin. High-frequency audiometry was performed pre- and post treatment. microdissection for surface preparation was carried out after death. An unusual blood vessel in the cochlea was found. The possible cause of this vascular abnormality in the human cochlea is discussed.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
3/4. Crossed renal ectopia associated with maternal alkaloid cocaine abuse: a case report.Although cocaine abuse has declined in popularity in the united states, certain groups continue to use the drug at high rates. The teratogenicity of cocaine has been widely investigated in the newborn. We report a case of crossed renal ectopia in a term neonate whose mother practiced alkaloid cocaine abuse in the first trimester of pregnancy. We propose that this anomaly was caused by cocaine's direct pharmacologic effect, leading to vasoconstriction that affected the developing fetal kidney by compromising the blood vessels that supply the organ or by causing hemorrhages and infarctions with fibrosis, causing disruption during a crucial period of morphogenesis.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |
4/4. Sagittal craniosynostosis and multiple skeletal anomalies in a 3-year-old boy.A patient with multiple congenital anomalies (sagittal craniosynostosis, complex of vertebral anomalies, additional left cervical rib at the C-7 level, common bifurcated head for the fourth and fifth left ribs, first right metacarpal hypoplasia, anomalies of the blood vessels of the upper extremities) and normal history of physical and mental development is presented.- - - - - - - - - - ranking = 1keywords = vessel (Clic here for more details about this article) |