Gene therapy for cancer: regulatory considerations for approval
AAV vectors pose little toxicity, since this virus does not cause any pathologic effects in humans. Herpes simplex virus vectors have the advantage of being able to infect non-dividing cells, and have the capacity to .... involve gene therapy vector ...
Nature.com - Fri, 20 Nov 2015 03:22

Readying HRD Test for Early-Access Launch, Myriad Reports Data to Strengthen ...
Johnathan Lancaster, chief medical officer of Myriad Genetic Laboratories, told GenomeWeb at SABCS that the company is in the process of identifying academic sites that see ovarian cancer patients who are commonly treated with platinum-based therapies ...
GenomeWeb - Thu, 10 Dec 2015 05:21



Imaging the Deceased: Post-mortem Radiology
While the autopsy process didn't change for them, CT imaging provided additional information, helping direct the autopsy or support the findings. It's useful to show evidence, particularly in ... X-ray has been used in forensic pathology for more than ...
Diagnostic Imaging - Thu, 03 Mar 2016 09:37



Healthy and diseased corticospinal motor neurons are selectively transduced ...
This study not only sets the stage for selective CSMN transduction in preclinical disease models of ALS but also enables visualization and assessment of CSMN axons and their interaction with spinal cord targets. Therefore, our findings are relevant for ...
Nature.com - Thu, 21 Jan 2016 03:20



Highlights From the European Cancer Congress: Breast Cancer
The pathologic complete response (pCR) rate with lapatinib was significantly lower than in the combination with trastuzumab (22.7 vs 30.3%; P=.004). At ECC, investigators presented final data on distant disease-free survival (DDFS), disease-free ...
Medscape - Fri, 23 Oct 2015 09:20



An abnormal secretion of soluble mediators contributes to the hematopoietic ...
Although the major part of the soluble mediators has a pleiotropic, bidirectional and synergic effect both in normal and pathologic processes, our results seems to increasingly support the novel concept of a myelodysplatic niche disease in which the ...
Nature.com - Fri, 27 Nov 2015 06:15



miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia
... ET patients with the aim of characterizing the expression pattern of miRNAs involved in JAK2V617F-negative ET and identifying potential targets for these miRNAs that may explain the pathogenesis of the disease and be considered as potential ...
Nature.com - Fri, 18 Mar 2016 07:21



Exercise in Regulation of Inflammation-Immune Axis Function in Cancer ...
[8-13] Collectively, these data have led to the provocative hypothesis that postdiagnosis exposure to exercise may inhibit disease progression—prompting calls from many stakeholders regarding the need for large-scale definitive clinical trials to test ...
Cancer Network - Tue, 15 Dec 2015 19:56


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