An abnormal secretion of soluble mediators contributes to the hematopoietic ...
Although the major part of the soluble mediators has a pleiotropic, bidirectional and synergic effect both in normal and pathologic processes, our results seems to increasingly support the novel concept of a myelodysplatic niche disease in which the ... - Fri, 27 Nov 2015 06:15

Linking Immune Responses With Fibrosis in Allergic Eye Disease
Dendritic cells are required in mediating allergic disease by activating pathologic T lymphocytes. Recent findings pointing to a central role for dendritic cell in fibrosis may, however, mean that these cells could also be contributing directly to ...
Medscape - Thu, 26 Nov 2015 21:03

Friday's Top Stock Losers: ABGB, STRP, SGY, BXE, GALT
... research and development to create therapies for fibrotic disease and cancer. The company has a market cap of $65.42 million. The company's drug candidates are based on its method of targeting galectin proteins, which are mediators of biologic and ...
Independent Reporter - Sat, 28 Nov 2015 04:45

Galectin Therapeutics Trading Down 7.9% (GALT)
The company's drug candidates are based on its method of targeting galectin proteins, which are mediators of biologic and pathologic functions. It uses naturally occurring, readily-available plant materials as starting material in manufacturing ...
Putnam Standard - Fri, 27 Nov 2015 14:07

Massive localized lymphedema: a clinicopathologic study of 46 patients with an ...
Mostly, the clinical impression was benign processes, including pannus or lymphedema pseudotumor. Grossly, the mean weight was 8237 g and the mean size was 53.2 cm. Histologically, eight cases showed a unique ... It was first described in 1998 as a ... - Fri, 20 Nov 2015 04:33

Nucleic acid targeting: towards personalized therapy for head and neck cancer
Within the cell, molecular machinery process shRNA and siRNA to generate single-stranded RNA fragments that bind complementary sequences on mRNA, leading to their degradation (Figure 2). Multiple cancer-associated genes can be simultaneously .... In a ... - Mon, 23 Nov 2015 02:52

Multimodal imaging reveals temporal and spatial microglia and matrix ...
Either they exhibit a detrimental function by releasing pro-inflammatory cytokines and chemotactic proteins, thereby amplifying the inflammatory reaction, or they have a beneficial function by promoting repair processes. ...... Up to now [18F]DPA-714 ... - Fri, 30 Oct 2015 06:30

Gene therapy for cancer: regulatory considerations for approval
AAV vectors pose little toxicity, since this virus does not cause any pathologic effects in humans. Herpes simplex virus vectors have the advantage of being able to infect non-dividing cells, and .... The FDA recommends performing these tests ... - Fri, 20 Nov 2015 03:22

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Last update: September 2014