Breakthrough T-Cell Therapy Halts EBV-Associated Lymphoproliferative Disorders
Infusions of Epstein-Barr virus (EBV)–specific cytotoxic T lymphocytes (CTLs) from healthy donors led to high response rates and significant extensions in overall survival (OS) for patients with rituximab-refractory EBV–associated lymphoproliferative ...
OncLive - Sun, 19 Apr 2015 06:10

VISA - Vector Integration Site Analysis server: a web-based server to rapidly ...
Retroviral vector mediated gene therapy has enormous potential for treating genetic disorders [1] and infectious diseases [2]. Unfortunately, vector integration can lead to the dysregulation of nearby genes, commonly referred to as genotoxicity [3 ...
BMC Blogs Network - Mon, 06 Jul 2015 06:41

New guidelines address primary cutaneous T-cell lymphoproliferative disorders
HOLLYWOOD, FLA. – The treatment of patients with lymphomatoid papulosis depends on the presentation, according to new National Comprehensive Cancer Network guidelines for managing primary cutaneous CD30+ T-cell lymphoproliferative disorders.
The Oncology Report - Wed, 16 Apr 2014 13:19

Higher Rates of Lymphoproliferative Disorders in Patients with Celiac Disease
A team of researchers recently investigated rates of various lymphoproliferative disorders in patients with celiac disease. The research team included L.A. Leslie, B. Lebwohl, A.I. Neugut, J. Gregory Mears, G. Bhagat, and P.H. Green. They are ...
Celiac.com - Mon, 30 Jul 2012 00:18

Effect of Genzyme's Multiple Sclerosis Treatment Lemtrada® (alemtuzumab) on ...
The Phase III trials of Lemtrada were randomized, two-year pivotal studies comparing treatment with Lemtrada to high-dose subcutaneous interferon beta-1a (Rebif®) in patients with RRMS who had active disease and were either new to treatment (CARE-MS ...
MarketWatch - Thu, 23 Apr 2015 05:56



Likely trigger for autoimmune disease found in newly-discovered rogue cells
Mutated FAS has already been linked to autoimmune disease. Patients with FAS mutations develop autoimmune lymphoproliferative syndrome (ALPS) where the body cannot control the number of immune cells (lymphocytes). This leads to enlarged lymph ...
Medical News Today - Thu, 14 May 2015 03:05

Researchers Discover Trigger that Likely Unleashes Autoimmune Disease
Scicasts (press release) (blog) - Thu, 14 May 2015 11:22

Waldenstrom macroglobulinemia: prognosis and management
The main causes of death because of WM include disease progression, transformation to high-grade lymphoma or complications of therapy. However, owing to the advanced age of these patients, many will die of unrelated causes. Mortality is linked to the ...
Nature.com - Fri, 27 Mar 2015 07:12

Laboratory Clues to Immunodeficiency; Missed Chances for Early Diagnosis?
The significance of a selective low IgM is unclear although it can be associated to ageing, autoimmunity and lymphoproliferative disease. A selective low IgA is found in many apparently healthy people although may be associated with autoimmunity ...
Medscape - Sun, 15 Feb 2015 21:03


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Last update: September 2014