Relaxed DNA may contribute to aging
People with Werner syndrome—a rare disease with symptoms that mimic premature aging—usually go gray in their 20s, develop cataracts and osteoporosis in their 30s, and die before 60. Now, researchers have for the first time created a key class of ...
Science /AAAS - Thu, 30 Apr 2015 11:35

Scientists Discover Secret to Keeping Cells Young
Newsmax - Fri, 01 May 2015 09:18

New Study Data Could Lead to Reversal of Aging Process
Genetic Engineering & Biotechnology News - Fri, 01 May 2015 07:01

Researchers discover key driver of human aging
Medical Xpress - Thu, 30 Apr 2015 11:11

Scientists Reverse Aging By Tightly Packing DNA Together In Cells
Medical Daily - Fri, 01 May 2015 13:15

Genetic find could help fight cancer and diabetes
Scotsman - Thu, 30 Apr 2015 15:52



Scientists Discover the Secret to Keeping Cells Young
In a study published Thursday in Science, an international team, led by Juan Carlos Izpisua Belmonte at the Salk Institute, studied the gene responsible for an accelerated aging disease known as Werner syndrome, or adult progeria, in which patients ...
TIME - Thu, 30 Apr 2015 11:00



A central mechanism of aging identified – and it might be reversible
People with Werner syndrome age faster than normal because of a genetic mutation that disrupts normal DNA cell processes. It affects around one in every 200,000 people in the United States, with sufferers plagued by early-onset age-related diseases ...
Gizmag - Wed, 06 May 2015 04:54



Premature Aging Syndrome Caused By Chromatin Chaos
“Our findings show that the gene mutation that causes Werner syndrome results in the disorganization of heterochromatin and that this disruption of normal DNA packaging is a key driver of aging,” says Professor Juan Carlos Izpisua Belmonte, a senior ...
Asian Scientist Magazine - Thu, 07 May 2015 19:37



Q&A: Juan Carlos Izpisua Belmonte and the Secret of Aging
In the past, we have worked with induced pluripotent stem cells from Hutchinson–Gilford progeria syndrome and demonstrated that cells derived from this model recapitulate premature aging phenotypes observed in the patients. Werner syndrome is a ...
Laboratory Equipment - Thu, 21 May 2015 03:52

Heterochromatin and human aging
The molecular events that lead to human aging are poorly understood. Werner syndrome, which is characterized by premature aging, is caused by recessive mutations in the WRN gene. Juan Carlos Izpisua Belmonte, Guang-Hui Liu, Fuchou Tang and ...
Nature.com - Wed, 27 May 2015 07:03



Potentially Reversible Driver of Aging Found
Werner's syndrome is also known as "adult progeria." Hutchinson-Gilford Progeria Syndrome (HGPS) is a childhood disorder caused by mutations in one of the major architectural proteins of the cell nucleus. In HGPS patients the cell nucleus has ...
Bioscience Technology - Tue, 05 May 2015 08:09

Study of Rare Syndrome Unlocks Secret of Human Aging
Drug Discovery & Development - Wed, 06 May 2015 12:18

Scientists probe the genetics of ageing
BioNews - Tue, 05 May 2015 08:56

Key driver of human ageing discovered: heterochromatin alterations
Biotechin.Asia - Tue, 05 May 2015 21:30



Heterochromatin disorganization associated with premature ageing
Werner syndrome (also known as adult progeria) is a premature ageing disorder with phenotypes such as grey hair, osteoporosis and diabetes, which are linked to defects in mesodermal tissue. Werner syndrome is caused by mutations in the WRN gene, ...
Nature.com - Sun, 17 May 2015 21:30


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