|Targeting self-renewal pathways in cancer stem cells: clinical implications ...|
In the past decade, underlying cause discovered to be associated with tumor recurrence, metastasis and chemoresistance are a relatively small population of stem cells inhabiting each adult tissue called as the cancer stem cells (CSCs). These stem cells ...
Nature.com - Mon, 30 Nov 2015 06:15
|PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma ...|
These tumor-initiating cells share phenotypic and molecular traits with neural stem cells and glial progenitor cells of the normal adult central nervous system. As a result ... By using this method, we identified a cohort of genes in A2B5+ TPCs that ...
Nature.com - Mon, 30 Nov 2015 02:52
|5 Department of Bone Marrow Transplantation and Onco-Hematology, Maria ...|
The central nervous system (CNS) is involved in ~10% of cases and WBC counts are usually higher in T-ALL than in B-ALL. Prognostic factors specific to ..... WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 4th edn. IARC: Lyon, 2008.
Nature.com - Mon, 30 Nov 2015 06:42
|Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath ...|
Accounting for ~5% of soft tissue sarcomas, malignant peripheral nerve sheath tumors occur either sporadically or in the setting of neurofibromatosis type 1 (each accounting for ~50% of cases); 10% of tumors in both patient groups arise following ...
Nature.com - Fri, 20 Nov 2015 04:33
|A novel BRD4-NUT fusion in an undifferentiated sinonasal tumor highlights ...|
Molecular analysis of the tumor tissue identified a novel in-frame BRD4-NUT transcript, with BRD4 exon 15 fused to the last 124 nucleotides of NUT exon 2 (BRD4-NUT ex15:ex2Δnt1–585). The partial deletion of NUT exon 2 was attributed to a mid-exonic ...
Nature.com - Mon, 09 Nov 2015 06:15
|Inhibition of tribbles protein-1 attenuates radioresistance in human glioma cells|
The malignant glioma is a cancer in the central nervous system. The therapeutic effect on this tumor is poor currently. Radiotherapy is one of the major remedies in the treatment of glioma. One of the major drawbacks of radiotherapy is the development ...
Nature.com - Mon, 02 Nov 2015 02:41
|Childhood cancer survivors at heightened risk of several autoimmune diseases|
Those who had had leukaemia, Hodgkin's lymphoma, kidney cancer, and central nervous system tumours seemed to be at greatest risk of developing an autoimmune disorder in later life. They were up to 60% more likely to do so than those who had not had ...
Medical Xpress - Tue, 10 Nov 2015 15:37
|How to light up a tumour|
Fluorescence imaging could allow surgeons to identify tissue that needs to be cut out, such as tumours, and tissue that needs to be avoided, such as blood vessels and nerves. The visual aid can also help determine whether a tumour can be operated on ...
The Guardian - Wed, 09 Sep 2015 21:59