SAPPHIRE-I, II: Treatment sustained despite hyperbilirubinemia in some HCV ...
Researchers, including Gregory T. Everson, MD, of the University of Colorado in Denver, analyzed the frequency of hyperbilirubinemia and clinical jaundice in patients with HCV genotype 1 (n=770) enrolled in the SAPPHIRE-I and II phase 3 trials and ...
Healio - Wed, 10 Sep 2014 12:26

Detecting jaundice in babies? There could be an app for that
Bilirubin passes through the liver on its way out of the body. When levels of bilirubin in the blood are high (a condition known as hyperbilirubinemia), it might mean there's a problem with the liver. When levels become extremely high, patients develop ...
WNAX - Mon, 22 Sep 2014 21:18



The Changing HCV Landscape:
Adverse events associated with simeprevir included hyperbilirubinemia related to interactions with transporters but no actual hepatotoxicity; a slight increase in photosensitivity; and in one study, mild pruritus. No additional hemoglobin decline was ...
Infectious Disease Special Edition - Fri, 19 Sep 2014 10:15



Rivaroxaban and Liver Injury: Case Studies Add to Safety Questions
Observations: We report 2 patients with predominantly hepatocellular liver injury that had onset during treatment with rivaroxaban. Both were symptomatic, had massively elevated transaminase activity levels and hyperbilirubinemia, and fulfilled the ...
Monthly Prescribing Reference - Fri, 29 Aug 2014 10:26

New 96-Week ACTG Study Results Presented at CROI 2014; First Large Study ...
One percent, 16 percent and five percent discontinued ISENTRESS, atazanavir/r and darunavir/r, respectively, for toxicity largely due to clinical jaundice and hyperbilirubinemia with atazanavir/r, and gastrointestinal symptoms with both atazanavir/r ...
EIN News (press release) - Wed, 24 Sep 2014 03:18

Exelixis Announces Results from the COMET-1 Phase 3 Pivotal Trial of ...
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Sep. 1, 2014-- Exelixis, Inc. (NASDAQ:EXEL) today announced top-line results from the final analysis of COMET-1, the phase 3 pivotal trial of cabozantinib in men with metastatic castration-resistant ...
FiercePharma - Tue, 02 Sep 2014 09:02


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Last update: September 2014