Regorafenib Upped Survival in Asian Patients With Refractory mCRC
... hypertension (11%), hyperbilirubinemia (7%), hypophosphatemia (7%), alanine aminotransferase concentration increases (7%), aspartate aminotransferase concentration increases (6%), lipase concentration increases (4%), and maculopapular rash (4%).
Cancer Network - Fri, 22 May 2015 05:11

Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields ...
... low incidence of National Cancer Institute Common Terminology Criteria for Adverse Events grade 3 isolated alanine aminotransferase (ALT) elevation (3%) and potentially life-threatening concurrent ALT elevation with hyperbilirubinemia (Hy's Law, 0.6%).
Nature.com - Tue, 19 May 2015 03:02

Nanomeds can cure jaundice faster: Indian scientists
The latest findings, which are currently in press for publication in the Nanomedicine journal, open a new door for "cost-effective and efficient therapeutic treatment of hyperbilirubinemia, jaundice and associated diseases," according to group leader ...
Big News Network.com - Thu, 14 May 2015 04:39



Regorafenib Improves Survival in Treatment-Refractory Colorectal Cancer
The most common grade 3 or higher adverse events in the regorafenib group were hand-foot skin reaction, hypertension, hyperbilirubinemia, hypophosphatemia, elevated ALT/AST, elevated lipase concentration, and macropapular rash. The findings suggest ...
Cancer Therapy Advisor - Mon, 18 May 2015 09:05

Public Release: 7-May-2015 Evidence of efficacy of gene therapy in rodents ...
The Crigler-Najjar syndrome is an inherited disorder of bilirubin metabolism characterized by high serum levels of unconjugated hyperbilirubinemia due to hepatic deficit of bilirubin glucuronosyltransferase activity. Many mutations of UGT1A1 gene (2q37 ...
EurekAlert (press release) - Thu, 07 May 2015 08:00

Baxter BioScience to Expand Global Oncology Footprint with Acquisition of ...
Baxter International Inc. (NYSE:BAX) announced it has signed a definitive agreement to acquire the Oncaspar® (pegaspargase) product portfolio from Sigma-Tau Finanziaria S.p.A. The acquisition further accelerates the innovation capabilities and the ...
PharmiWeb.com (press release) - Tue, 12 May 2015 08:11

Clinical investigation on Theileria equi and Babesia caballi infections in ...
The most common hematological alteration found in horses is decreased packed cell volume, hemoglobin and erythrocyte number, in addition to hyperbilirubinemia and thrombocytopenia [3]. After subclinical, chronic or acute infection, donkeys usually ...
BMC Blogs Network - Mon, 27 Apr 2015 05:33

Cabozantinib and Cobimetinib to Be Featured in Fourteen Presentations at 2015 ...
The most common laboratory abnormalities (≥25%) are increased AST, increased ALT, lymphopenia, increased alkaline phosphatase, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia, and hyperbilirubinemia. Please see full U.S. ...
Yahoo Finance UK - Thu, 30 Apr 2015 13:15


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