Painkiller reduces hypersensitivity to pain in patients with fibromyalgia
These patients also complain of hyperalgesia, or increased sensitivity to pain. A University of Florida study published in the July issue of the European Journal of Pain has found that injections of the painkiller lidocaine in peripheral tissues such ...
University of Florida - Thu, 31 Jul 2014 13:30

Lidocaine Injections Quelled Pain Sensitivity for Fibromyalgia Patients
For subjects treated with lidocaine, mechanical hyperalgesia in their shoulders and buttocks decreased significantly (p = 0.004) in comparison to their saline-treated counterparts. The investigators also found a drop in heat hyperalgesia in lidocaine ...
HCPLive - Fri, 08 Aug 2014 12:49

Prescription drug abuse is a complicated problem that ruins lives and careers ...
... syndrome that can lead to prescription drug dependence or addiction. Oxycodone and other opiate medications are not indicated for chronic pain, and there is evidence that they actually worsen pain through a condition called opioid-induced hyperalgesia.
Baltimore Sun - Wed, 13 Aug 2014 08:56

FDA Approves Abuse-Deterrent Oxycodone/Naloxone Combo
The FDA is requiring postmarketing studies to assess the risks for misuse, abuse, hyperalgesia, addiction, overdose and death with Targiniq ER, and to further assess the effects of the abuse-deterrent features on the risk for abuse. "In addition ...
Medscape - Wed, 23 Jul 2014 15:30

'Abuse-Deterrent' Label Panned for New Opioid
MedPage Today - Thu, 24 Jul 2014 11:30

FDA approves Targiniq ER to treat severe pain - Thu, 24 Jul 2014 02:54

Targiniq ER painkiller pill designed to prevent abuse, gets FDA approval
... of its 'street marketability.'" The FDA still required Purdue Pharma to conduct postmarketing studies that would evaluate the serious risks associated with long term use of the drug including overdose, heightened sensitivity to pain or hyperalgesia ...
Tech Times - Sat, 26 Jul 2014 20:22

First Step towards Competent Opioid Prescribing for Chronic Pain
... benefit from this type of treatment.6 Critics also point to the emerging bodies of literature on opioid-induced hyperalgesia and endocrinopathy, but the data hardly indicate that all patients on chronic opioid therapy will develop these iatrogenic ...
HCPLive - Wed, 30 Jul 2014 13:18

Cause of Complex Regional Pain Syndrome Further Examined
For an 8-day period, investigators observed the mice's “mechanical hyperalgesia, paw swelling, heat and cold sensitivity, weight-bearing ability, locomotor activity, motor coordination, paw temperature, and body weight.” Proinflammatory sensory ...
HCPLive - Tue, 05 Aug 2014 07:12

Complex Regional Pain Syndrome May Not Be Caused by Trauma
Complex Regional Pain Syndrome (CRPS) could be caused by harmful serum autoantibodies, according to research from the University of Liverpool's Institute of Translational Medicine. The study led investigators to believe that CRPS is caused by an ...
HCPLive - Mon, 28 Jul 2014 06:00

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Last update: April 2009