Is Opioid-Induced Hyperalgesia a Real Phenomenon?
Gudin, Director of Pain Management, Englewood Hospital and Medical Center, Englewood, NJ, described opioid-induced hyperalgesia (OIH) as dramatically increased sensitivity to painful stimuli or pain elicited by nonpainful stimulus following treatment ...
HCPLive - Sat, 20 Sep 2014 09:30

Epigenetic regulation of spinal cord gene expression controls Opioid-Induced ...
The long term use of opioids for the treatment of pain leads to a group of maladaptations which includes opioid-induced hyperalgesia (OIH). OIH typically resolves within few days after cessation of morphine treatment in mice but is prolonged for weeks ...
7thSpace Interactive (press release) - Fri, 12 Sep 2014 05:45

Inflammatory and oxidative and nitrosative stress cascades as new drug targets ...
Patients with ME and CFS show higher scores on fatigue, neurocognitive disorders, hyperalgesia, autonomic symptoms, postexertional malaise and a subjective feeling of infection than patients with CF. ME is characterized by increased postexertional ...
ProHealth - Wed, 01 Oct 2014 00:07

New AAN Position Statement on Opioids for Noncancer Pain
For mild to moderate pain conditions, such as headache, fibromyalgia, and chronic low back pain, the risks for overdose, addiction, or serious adverse effects associated with long-term use of opioids likely outweigh the benefits, a new position paper ...
Medscape - Mon, 29 Sep 2014 13:15



Unique Tonix Could Go Higher On BESTFIT Data (TNXP)
It is intriguing to note that many of the negative effects of opioids, which include fatigue, sleep disturbance, increased pain due to hyperalgesia, and poor mood, are symptoms comparable with the typical symptoms of fibromyalgia. Hyperalgesia ...
Seeking Alpha (registration) - Tue, 23 Sep 2014 11:08

Combining epilepsy drug, morphine can result in less pain, lower opioid doses
In fact, research indicates that the pain of hyperalgesia occurs because the morphine latches on not only to cellular targets that reduce pain sensation but to other "non-opioid" targets that result in activation of pain-sensing neurons. Dr. White and ...
Medical Xpress - Mon, 15 Sep 2014 11:22

Understanding the Microbiome and Its Impact on Human Health
Manning noted that L. acidophilus NCFM modulates intestinal pain and induces opioid and cannabinoid receptors, while L. reuteri and L. paracosci prevents or reverses antiobiotic-induced hyperalgesia. The probiotic L. plantarum inhibits inflammatory ...
HCPLive - Sat, 20 Sep 2014 10:48

For Chronic Pain Patients Unrelieved by High-Dose Opioids, What Next?
Prolonged opioid therapy can result in tolerance, dependence, and opioid-induced hyperalgesia; it has also been linked to decreased fertility and libido and immunosuppression. While progressively higher doses of opioids may help treat pain initially, ...
Monthly Prescribing Reference - Thu, 18 Sep 2014 11:33


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Last update: September 2014