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Ketamine Offers Opioid-Sparing in Pediatric Patients
“General anesthesia maintained with high-dose remifentanil is associated with acute opioid tolerance and/or hyperalgesia, which is usually manifested by increased postoperative pain and opioid requirement,” said Rie Minoshima, MD, professor of ...
Anesthesiology News - Thu, 17 Apr 2014 15:30

No evidence for long-term opioids in low back pain
There were no reports of serious adverse effects, risks (addiction or overdose) or complications (sleep apnea, opioid-induced hyperalgesia, hypogonadism). The overall quality of the trials included in the analysis was low to moderate. Study limitations ...
Clinical Advisor - Thu, 17 Apr 2014 08:11

Antineuropathic effect of 7-hydroxy-3,4-dihydrocadalin in streptozotocin ...
Results: After 3 weeks of diabetes induction, chemical hyperalgesia was observed in streptozotocin-injected rats. Oral acute administration of 7-hydroxy-3,4-dihydrocadalin (0.3-30 mg/kg) decreased in a dose-dependent manner formalin-evoked hyperalgesia ...
7thSpace Interactive (press release) - Mon, 07 Apr 2014 00:52

Fibromyalgia: Changes in Diagnosis, Treatment
The article also points out that opioids, while often used to treat peripheral pain, should be discouraged for patients with fibromylagia. In fact, opioids may actually worsen fibromyalgia-related hyperalgesia. Fibromyalgia: Changes in Diagnosis ...
Monthly Prescribing Reference - Wed, 16 Apr 2014 12:21

Zogenix executive says Mass. drug ban 'makes no sense whatsoever'
In its Oct. 25 approval of Zohydro, the FDA stated that the drug poses “serious risks of misuse, abuse, increased sensitivity to pain (hyperalgesia), addiction, overdose, and death associated with long-term use beyond 12 weeks.” Because of the drug's ...
San Francisco Business Times (blog) - Wed, 09 Apr 2014 14:08

Evidence Lacking for Long-Term Opioid Use in Low Back Pain
There were no reports of serious adverse effects, risks (addiction or overdose), or complications (sleep apnea, opioid-induced hyperalgesia, hypogonadism). Quality of the trials was low to moderate and the trials also had high dropout rates, short ...
Doctors Lounge - Wed, 16 Apr 2014 10:03

PAINWeekEnd Houston: A Day of Pain Management CME You'll Use All Year!
Course topics include the fundamentals of pain and addiction; opioid conversions; opioid-induced hyperalgesia; and special considerations for methadone therapy. Attendees will also learn critically important skills in documentation and lab testing that ...
SYS-CON Media (press release) - Wed, 09 Apr 2014 02:56

Treatment-Resistant Woman with Fibromyalgia Experiences Marked ...
... so effective in treating a variety of pain syndromes, including severe pelvic pain and interstitial cystitis in women with the sympathetic neural hyperalgesia edema syndrome would also mitigate pain from fibromyalgia which was resistant to multiple ...
ProHealth - Thu, 10 Apr 2014 00:01


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