Mesenchymal stem cell transplantation reduces opioid tolerance, opioid-induced ...
Mesenchymal stem cell (MSC) transplantation reduced opioid tolerance and opioid-induced hyperalgesia caused by daily morphine injections in rats, according to new research. The results could herald stem cell transplantation as an innovative, safe, ...
News-Medical.net - Wed, 25 Mar 2015 02:46

Cleveland Clinic Researchers First to Demonstrate Significant Blocking of ...
Newswise — March 24, 2015, NATIONAL HARBOR, Md. –- Mesenchymal stem cell (MSC) transplantation reduced opioid tolerance and opioid-induced hyperalgesia caused by daily morphine injections in rats, according to new research. The results could ...
Newswise (press release) - Sat, 21 Mar 2015 02:22



Hyperalgesia May Be Reversible After Spinal Pain Pathway Reactivation
Research using an animal model of pain suggests that mechanical hyperalgesia may be reversible in mice after spinal pain pathways are reactivated in a manner analogous to memory reconsolidation. This previously unobserved regulatory mechanism ...
HCPLive - Thu, 02 Oct 2014 17:56



Chronic Noncancer Pain: Is It Time for A New Treatment Direction?
These changes result in less effective μ-receptor function (tolerance) and changes in the ability to regulate pain (hyperalgesia). 4 Opioids also may change macroscopic areas of the brain such as the frontal cortex, hypothalamus, insula, anterior ...
Pain Medicine News - Tue, 10 Mar 2015 07:34



Opioid Tolerance or Hyperalgesia? Key Symptoms Offer Clues
Concerns about hyperalgesia as opioid overuse in general faces intense public and regulatory scrutiny were evident from the overflowing crowd spilling out into a hallway at the meeting to hear Dr. Silverman address the issue here at PAINWeek 2013.
Medscape - Mon, 16 Sep 2013 06:41



Possible New Treatment for Opioid-Induced Hyperalgesia
Fort Lauderdale, Florida — Researchers might have found an answer to the puzzling and sometimes controversial problem of opioid-induced hyperalgesia (OIH). A new study shows that dexmedetomidine, a highly selective α2 agonist that boosts ...
Medscape - Mon, 15 Apr 2013 12:03

Explore hyperalgesia therapeutic pipeline market review H1 2015
This report provides comprehensive information on the therapeutic development for Hyperalgesia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and ...
WhaTech - Tue, 24 Jun 2014 02:22

Dexmedetomidine may be an effective treatment option for opioid-induced ...
Surgical patients who demonstrated heightened pain sensitivity, or hyperalgesia, induced by high doses of a synthetic opioid had their symptoms alleviated by co-treatment with dexmedetomidine, according to new research. Study investigators, who ...
News-Medical.net - Fri, 12 Apr 2013 06:43


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Last update: September 2014