Epigenetic regulation of spinal cord gene expression controls Opioid-Induced ...
The long term use of opioids for the treatment of pain leads to a group of maladaptations which includes opioid-induced hyperalgesia (OIH). OIH typically resolves within few days after cessation of morphine treatment in mice but is prolonged for weeks ...
7thSpace Interactive (press release) - Fri, 12 Sep 2014 05:45

Adding common epilepsy drug to morphine can result in better pain control, say ...
... treating pain, they can result in dependence and produce side effects including respiratory depression, nausea, constipation and other problems. In addition, such drugs can, paradoxically, actually cause pain, a condition called opioid-induced ...
News-Medical.net - Wed, 17 Sep 2014 00:10

Combining epilepsy drug, morphine can result in less pain, lower opioid doses
In fact, research indicates that the pain of hyperalgesia occurs because the morphine latches on not only to cellular targets that reduce pain sensation but to other "non-opioid" targets that result in activation of pain-sensing neurons. Dr. White and ...
Medical Xpress - Mon, 15 Sep 2014 11:22

Fibromyalgia Links Modified Brain Signals For Pain
Brain-Signals_110613-617x416 Hyperalgesia could be a condition that causes a pause within the brain signals for reward and penalty. These findingscounsel a link between this altered brain procedure and widespread pain that's immune to opiod medical ...
Angle Chronicle - Sun, 14 Sep 2014 03:30

Underlying Factors that Exist Outside of Pain Drive Prescription Opioid Use ...
Negative attributes of prescription opioids include tolerance/physical dependence, immunosuppression, opioid-induced endocrinopathy, and opioid-induced hyperalgesia. She said that positive toxicology results at the time of injury predicts an extended ...
Monthly Prescribing Reference - Sat, 06 Sep 2014 12:30

Management of Fibromyalgia Syndrome: Review of Evidence
Fibromyalgia syndrome (FMS) is a common chronic musculoskeletal pain disorder of unknown etiology and characterized by generalized body pain, hyperalgesia, and other functional and emotional comorbidities. Despite extensive research, no treatment ...
ProHealth - Sun, 07 Sep 2014 02:56



Advances in the Management of Constipation-predominant Irritable Bowel ...
Possible mechanisms for visceral hyperalgesia include neurokinin 1, corticotropin-releasing factor 1, vasopressin 3, vanilloid (TRPV1), and endocannabinoid (CB1) receptors [Bradesi et al. 2009; Hong et al. 2009; Schwetz et al. 2004]. Linaclotide (MD ...
Medscape - Wed, 27 Aug 2014 21:18

Suspect Small Fiber Neuropathies for Unexplained Neuropathic Pain
Possible findings included decreased pin prick, diminished thermal sensation, hyperalgesia, and dry skin. Diagnostic studies include blood tests, X-ray, CT, MRI, quantitative sensory testing, and epidermal skin biopsy. Although electromyography and ...
Monthly Prescribing Reference - Thu, 04 Sep 2014 14:06


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Last update: September 2014