Inhibitory activities of the marine streptomycete-derived compound SF2446A2 ...
The compound SF2446A2, a naphthacene glycoside previously reported from soil-derived Streptomyces sp. strain SF2446, was found to exhibit strong activity against Gram-positive bacteria and several mycoplasma strains including the macrolide-resistant ...
Nature.com - Tue, 19 May 2015 23:22

Lakewood-Amedex: Novel Class Of Antimicrobials Kills Multidrug Resistant ...
This result highlights the novel directly bactericidal mechanism of action of the bisphosphocin class, which is time and concentration dependent, resulting in killing of gram positive and gram negative bacteria in less time than they take to replicate ...
Drug Discovery & Development - Wed, 20 May 2015 09:52

Theravance Biopharma Posts Positive Data on Velusetrag
Approval and subsequent launch of newer therapies will reduce the company's dependence on its sole marketed drug, Vibativ (Staphylococcus aureus and other Gram-positive bacteria infections). The company is looking to expand the label of Vibativ.
Zacks.com - Tue, 19 May 2015 12:27



Daptomycin Safe for Children With Skin Infections
With multidrug-resistant bacteria an ever-increasing threat to adult and younger patients alike, daptomycin has gained value as a powerful bactericidal, with a highly potent antibiotic effect against gram-positive pathogens in adults. Dr Bradley and ...
Medscape - Mon, 18 May 2015 13:37

Synthesis and antibacterial activity of 4″ or 6″-alkanoylamino derivatives ...
Aminoglycoside antibiotics have been widely used in the treatment of serious infections caused by Gram-positive and/or Gram-negative bacteria. They interfere with bacterial protein synthesis by binding to the A-site decoding region of 16S rRNA in the ...
Nature.com - Tue, 19 May 2015 23:22

Lakewood-Amedex's novel class of antimicrobials prove effective at killing MDR ...
This result highlights the novel directly bactericidal mechanism of action of the bisphosphocin class, which is time and concentration dependent, resulting in killing of gram positive and gram negative bacteria in less time than they take to replicate ...
News-Medical.net - Tue, 19 May 2015 12:22



Roadmap to reward pharma for creating new antibiotics unveiled
Pharma firms need better incentives to create novel antibiotics to head off an 'apocalyptic scenario' where commonplace infections become deadly once more. And the latest report ... But drug companies complain that developing novel antibiotics is a bad ...
Royal Society of Chemistry - Tue, 19 May 2015 04:26



There's no place like home
Staphylococcus aureus is a Gram-positive bacterium that, in humans, is frequently found in the upper respiratory tract and on the skin. Methicillin-resistant S. aureus (MRSA) was first described in the 1960s, and it has become increasingly widespread ...
Nature.com - Fri, 15 May 2015 05:45


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